Glypican-4 in pregnancy and its relation to glucose metabolism, insulin resistance and gestational diabetes mellitus status
Abstract Glypican-4 (GPC-4) is an adipokine that enhances insulin receptor signaling. Plasma concentrations were found to be elevated in patients with prediabetes but reduced in type 2 diabetes mellitus. No study on Glypican-4 in pregnancy and pregnancy-related insulin resistance has been published...
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| Format: | Article |
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Nature Portfolio
2021-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-03454-x |
| _version_ | 1819096142895382528 |
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| author | Carola Deischinger Jürgen Harreiter Karoline Leitner Luna Wattar Sabina Baumgartner-Parzer Alexandra Kautzky-Willer |
| author_facet | Carola Deischinger Jürgen Harreiter Karoline Leitner Luna Wattar Sabina Baumgartner-Parzer Alexandra Kautzky-Willer |
| author_sort | Carola Deischinger |
| collection | DOAJ |
| description | Abstract Glypican-4 (GPC-4) is an adipokine that enhances insulin receptor signaling. Plasma concentrations were found to be elevated in patients with prediabetes but reduced in type 2 diabetes mellitus. No study on Glypican-4 in pregnancy and pregnancy-related insulin resistance has been published yet. GPC-4 levels were investigated in 59 overweight women throughout their pregnancy at the Medical University of Vienna. GPC-4 levels, fasting insulin, fasting glucose, estradiol, liver and renal parameters, and markers of bone development were assessed before the < 21st week of gestation (GW), and at GW 35–37. GPC-4 levels increased from < 21 GW (mean = 2.38 pg/ml, SD = 0.68 pg/ml) to GW 35–37 (mean = 2.96 pg/ml, SD = 0.77 pg/ml, p < 0.001). At the same time, GPC-4 levels correlated negatively with estimated glomerular filtration rate (eGFR), serum protein and serum albumin levels and were positively related to creatinine and uric acid levels at GW 35–37. Concerning glucose metabolism, GPC-4 levels were inversely related to ISSI-2, fasting insulin and HOMA-IR, however, not significantly different between women with normal glucose tolerance (NGT) and GDM (p = 0.239). In conclusion, GPC-4 levels rose significantly during pregnancy, correlated negatively with fasting insulin and HOMA-IR but might not be related to gestational diabetes mellitus status. |
| first_indexed | 2024-12-21T23:54:30Z |
| format | Article |
| id | doaj.art-8f83f50a021e4e949d10d83ffa947477 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-21T23:54:30Z |
| publishDate | 2021-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-8f83f50a021e4e949d10d83ffa9474772022-12-21T18:45:50ZengNature PortfolioScientific Reports2045-23222021-12-011111710.1038/s41598-021-03454-xGlypican-4 in pregnancy and its relation to glucose metabolism, insulin resistance and gestational diabetes mellitus statusCarola Deischinger0Jürgen Harreiter1Karoline Leitner2Luna Wattar3Sabina Baumgartner-Parzer4Alexandra Kautzky-Willer5Clinical Division of Endocrinology and Metabolism, Gender Medicine Unit, Department of Internal Medicine III, Medical University of ViennaClinical Division of Endocrinology and Metabolism, Gender Medicine Unit, Department of Internal Medicine III, Medical University of ViennaClinical Division of Endocrinology and Metabolism, Gender Medicine Unit, Department of Internal Medicine III, Medical University of ViennaClinical Division of Endocrinology and Metabolism, Gender Medicine Unit, Department of Internal Medicine III, Medical University of ViennaClinical Division of Endocrinology and Metabolism, Gender Medicine Unit, Department of Internal Medicine III, Medical University of ViennaClinical Division of Endocrinology and Metabolism, Gender Medicine Unit, Department of Internal Medicine III, Medical University of ViennaAbstract Glypican-4 (GPC-4) is an adipokine that enhances insulin receptor signaling. Plasma concentrations were found to be elevated in patients with prediabetes but reduced in type 2 diabetes mellitus. No study on Glypican-4 in pregnancy and pregnancy-related insulin resistance has been published yet. GPC-4 levels were investigated in 59 overweight women throughout their pregnancy at the Medical University of Vienna. GPC-4 levels, fasting insulin, fasting glucose, estradiol, liver and renal parameters, and markers of bone development were assessed before the < 21st week of gestation (GW), and at GW 35–37. GPC-4 levels increased from < 21 GW (mean = 2.38 pg/ml, SD = 0.68 pg/ml) to GW 35–37 (mean = 2.96 pg/ml, SD = 0.77 pg/ml, p < 0.001). At the same time, GPC-4 levels correlated negatively with estimated glomerular filtration rate (eGFR), serum protein and serum albumin levels and were positively related to creatinine and uric acid levels at GW 35–37. Concerning glucose metabolism, GPC-4 levels were inversely related to ISSI-2, fasting insulin and HOMA-IR, however, not significantly different between women with normal glucose tolerance (NGT) and GDM (p = 0.239). In conclusion, GPC-4 levels rose significantly during pregnancy, correlated negatively with fasting insulin and HOMA-IR but might not be related to gestational diabetes mellitus status.https://doi.org/10.1038/s41598-021-03454-x |
| spellingShingle | Carola Deischinger Jürgen Harreiter Karoline Leitner Luna Wattar Sabina Baumgartner-Parzer Alexandra Kautzky-Willer Glypican-4 in pregnancy and its relation to glucose metabolism, insulin resistance and gestational diabetes mellitus status Scientific Reports |
| title | Glypican-4 in pregnancy and its relation to glucose metabolism, insulin resistance and gestational diabetes mellitus status |
| title_full | Glypican-4 in pregnancy and its relation to glucose metabolism, insulin resistance and gestational diabetes mellitus status |
| title_fullStr | Glypican-4 in pregnancy and its relation to glucose metabolism, insulin resistance and gestational diabetes mellitus status |
| title_full_unstemmed | Glypican-4 in pregnancy and its relation to glucose metabolism, insulin resistance and gestational diabetes mellitus status |
| title_short | Glypican-4 in pregnancy and its relation to glucose metabolism, insulin resistance and gestational diabetes mellitus status |
| title_sort | glypican 4 in pregnancy and its relation to glucose metabolism insulin resistance and gestational diabetes mellitus status |
| url | https://doi.org/10.1038/s41598-021-03454-x |
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