Upregulation of Prickle2 Ameliorates Alzheimer’s Disease-Like Pathology in a Transgenic Mouse Model of Alzheimer’s Disease

Upregulation of Prickle2 Ameliorates Alzheimer’s Disease-Like Pathology in a Transgenic Mouse Model of Alzheimer’s Disease

Alzheimer’s disease (AD) is a devastating neurodegenerative disorder that has no effective therapies. Prickle planar cell polarity protein 2 (Prickle2), is an important cytoplasmic regulator of Wnt/PCP signaling. It has been reported that Prickle2 deficiency reduced neurite outgrowth levels in mouse...

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Bibliographic Details
Main Authors:	Fengxian Sun, Fang Jiang, Na Zhang, Hua Li, Weiping Tian, Weiying Liu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-09-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	Prickle2 Alzheimer’s disease oxidative stress neuroinflammation Wnt/PCP pathway
Online Access:	https://www.frontiersin.org/article/10.3389/fcell.2020.565020/full

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