Neuroprotective Effect of siRNA Entrapped in Hyaluronic Acid-Coated Lipoplexes by Intravitreal Administration

Neuroprotective Effect of siRNA Entrapped in Hyaluronic Acid-Coated Lipoplexes by Intravitreal Administration

Since the possibility of silencing specific genes linked to retinal degeneration has become a reality with the use of small interfering RNAs (siRNAs), this technology has been widely studied to promote the treatment of several ocular diseases. Despite recent advances, the clinical success of gene si...

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Bibliographic Details
Main Authors: Marcela Coelho Silva Ribeiro, Marcelo Coutinho de Miranda, Pricila da Silva Cunha, Gracielle Ferreira Andrade, Gustavo de Oliveira Fulgêncio, Dawidson Assis Gomes, Sílvia Ligorio Fialho, Frederico Pittella, Christine Charrueau, Virginie Escriou, Armando Silva-Cunha
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pharmaceutics
Subjects:
lipoplexes
hyaluronic acid
siRNA
caspase-3
retinal neuroprotection
intravitreal administration
Online Access:https://www.mdpi.com/1999-4923/13/6/845

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