Identification of a role for the PI3K/AKT/mTOR signaling pathway in innate immune cells.
The innate immune system is the first line of host defense against infection and involves several different cell types. Here we investigated the role of the phosphatidylinositol 3 kinase (PI3K) signaling pathway in innate immune cells. By blocking this pathway with pharmacological inhibitors, we fou...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3981814?pdf=render |
| _version_ | 1819102347422334976 |
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| author | Songbo Xie Miao Chen Bing Yan Xianfei He Xiwen Chen Dengwen Li |
| author_facet | Songbo Xie Miao Chen Bing Yan Xianfei He Xiwen Chen Dengwen Li |
| author_sort | Songbo Xie |
| collection | DOAJ |
| description | The innate immune system is the first line of host defense against infection and involves several different cell types. Here we investigated the role of the phosphatidylinositol 3 kinase (PI3K) signaling pathway in innate immune cells. By blocking this pathway with pharmacological inhibitors, we found that the production of proinflammatory cytokines was drastically suppressed in monocytes and macrophages. Further study revealed that the suppression was mainly related to the mammalian target of rapamycin (mTOR)/p70(S6K) signaling. In addition, we found that the PI3K pathway was involved in macrophage motility and neovascularization. Our data provide a rationale that inhibition of the PI3K signaling pathway could be an attractive approach for the management of inflammatory disorders. |
| first_indexed | 2024-12-22T01:33:07Z |
| format | Article |
| id | doaj.art-8f87e47bc79d4049b8cb76d5517fa9d8 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T01:33:07Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-8f87e47bc79d4049b8cb76d5517fa9d82022-12-21T18:43:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0194e9449610.1371/journal.pone.0094496Identification of a role for the PI3K/AKT/mTOR signaling pathway in innate immune cells.Songbo XieMiao ChenBing YanXianfei HeXiwen ChenDengwen LiThe innate immune system is the first line of host defense against infection and involves several different cell types. Here we investigated the role of the phosphatidylinositol 3 kinase (PI3K) signaling pathway in innate immune cells. By blocking this pathway with pharmacological inhibitors, we found that the production of proinflammatory cytokines was drastically suppressed in monocytes and macrophages. Further study revealed that the suppression was mainly related to the mammalian target of rapamycin (mTOR)/p70(S6K) signaling. In addition, we found that the PI3K pathway was involved in macrophage motility and neovascularization. Our data provide a rationale that inhibition of the PI3K signaling pathway could be an attractive approach for the management of inflammatory disorders.http://europepmc.org/articles/PMC3981814?pdf=render |
| spellingShingle | Songbo Xie Miao Chen Bing Yan Xianfei He Xiwen Chen Dengwen Li Identification of a role for the PI3K/AKT/mTOR signaling pathway in innate immune cells. PLoS ONE |
| title | Identification of a role for the PI3K/AKT/mTOR signaling pathway in innate immune cells. |
| title_full | Identification of a role for the PI3K/AKT/mTOR signaling pathway in innate immune cells. |
| title_fullStr | Identification of a role for the PI3K/AKT/mTOR signaling pathway in innate immune cells. |
| title_full_unstemmed | Identification of a role for the PI3K/AKT/mTOR signaling pathway in innate immune cells. |
| title_short | Identification of a role for the PI3K/AKT/mTOR signaling pathway in innate immune cells. |
| title_sort | identification of a role for the pi3k akt mtor signaling pathway in innate immune cells |
| url | http://europepmc.org/articles/PMC3981814?pdf=render |
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