Building bridges, not walls: spinal cord regeneration in zebrafish
Spinal cord injury is a devastating condition in which massive cell death and disruption of neural circuitry lead to long-term chronic functional impairment and paralysis. In mammals, spinal cord tissue has minimal capacity to regenerate after injury. In stark contrast, the regeneration of a complet...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
The Company of Biologists
2020-05-01
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| Series: | Disease Models & Mechanisms |
| Subjects: | |
| Online Access: | http://dmm.biologists.org/content/13/5/dmm044131 |
| _version_ | 1819110949065326592 |
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| author | Valentina Cigliola Clayton J. Becker Kenneth D. Poss |
| author_facet | Valentina Cigliola Clayton J. Becker Kenneth D. Poss |
| author_sort | Valentina Cigliola |
| collection | DOAJ |
| description | Spinal cord injury is a devastating condition in which massive cell death and disruption of neural circuitry lead to long-term chronic functional impairment and paralysis. In mammals, spinal cord tissue has minimal capacity to regenerate after injury. In stark contrast, the regeneration of a completely transected spinal cord and accompanying reversal of paralysis in adult zebrafish is arguably one of the most spectacular biological phenomena in nature. Here, we review reports from the last decade that dissect the mechanisms of spinal cord regeneration in zebrafish. We highlight recent progress as well as areas requiring emphasis in a line of study that has great potential to uncover strategies for human spinal cord repair. |
| first_indexed | 2024-12-22T03:49:50Z |
| format | Article |
| id | doaj.art-8f88260fd71a4c21807ffd0f8351e0fc |
| institution | Directory Open Access Journal |
| issn | 1754-8403 1754-8411 |
| language | English |
| last_indexed | 2024-12-22T03:49:50Z |
| publishDate | 2020-05-01 |
| publisher | The Company of Biologists |
| record_format | Article |
| series | Disease Models & Mechanisms |
| spelling | doaj.art-8f88260fd71a4c21807ffd0f8351e0fc2022-12-21T18:40:01ZengThe Company of BiologistsDisease Models & Mechanisms1754-84031754-84112020-05-0113510.1242/dmm.044131044131Building bridges, not walls: spinal cord regeneration in zebrafishValentina Cigliola0Clayton J. Becker1Kenneth D. Poss2 Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA Spinal cord injury is a devastating condition in which massive cell death and disruption of neural circuitry lead to long-term chronic functional impairment and paralysis. In mammals, spinal cord tissue has minimal capacity to regenerate after injury. In stark contrast, the regeneration of a completely transected spinal cord and accompanying reversal of paralysis in adult zebrafish is arguably one of the most spectacular biological phenomena in nature. Here, we review reports from the last decade that dissect the mechanisms of spinal cord regeneration in zebrafish. We highlight recent progress as well as areas requiring emphasis in a line of study that has great potential to uncover strategies for human spinal cord repair.http://dmm.biologists.org/content/13/5/dmm044131regenerationspinal cordzebrafish |
| spellingShingle | Valentina Cigliola Clayton J. Becker Kenneth D. Poss Building bridges, not walls: spinal cord regeneration in zebrafish Disease Models & Mechanisms regeneration spinal cord zebrafish |
| title | Building bridges, not walls: spinal cord regeneration in zebrafish |
| title_full | Building bridges, not walls: spinal cord regeneration in zebrafish |
| title_fullStr | Building bridges, not walls: spinal cord regeneration in zebrafish |
| title_full_unstemmed | Building bridges, not walls: spinal cord regeneration in zebrafish |
| title_short | Building bridges, not walls: spinal cord regeneration in zebrafish |
| title_sort | building bridges not walls spinal cord regeneration in zebrafish |
| topic | regeneration spinal cord zebrafish |
| url | http://dmm.biologists.org/content/13/5/dmm044131 |
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