The Effect of a Synthetic Estrogen, Ethinylestradiol, on the hERG Block by E-4031

The Effect of a Synthetic Estrogen, Ethinylestradiol, on the hERG Block by E-4031

Inhibition of K<sup>+</sup>-conductance through the human ether-a-go-go related gene (hERG) channel leads to QT prolongation and is associated with cardiac arrhythmias. We previously reported that physiological concentrations of some estrogens partially suppress the hERG channel currents...

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Bibliographic Details
Main Authors: Fumiya Tamura, Shintaro Sugimoto, Mana Sugimoto, Kazuho Sakamoto, Masahiko Yamaguchi, Takeshi Suzuki, Keiichi Fukuda, Masaki Ieda, Junko Kurokawa
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Biomolecules
Subjects:
cardiac potassium channel
hERG blocker
synthetic estrogen
QT intervals
drug interaction
Online Access:https://www.mdpi.com/2218-273X/11/9/1385

Internet

https://www.mdpi.com/2218-273X/11/9/1385

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