Thioredoxin glutathione reductase as a novel drug target: evidence from Schistosoma japonicum.
BACKGROUND: Schistosomiasis remains a major public health concern affecting billions of people around the world. Currently, praziquantel is the only drug of choice for treatment of human schistosomiasis. The emergence of drug resistance to praziquantel in schistosomes makes the development of novel...
Main Authors: | LiJun Song, JiaHuang Li, ShuYing Xie, ChunYan Qian, Jie Wang, Wei Zhang, Xuren Yin, ZiChun Hua, ChuanXin Yu |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3285170?pdf=render |
Similar Items
-
Cheminformatics Models for Inhibitors of Schistosoma mansoni Thioredoxin Glutathione Reductase
by: Sonam Gaba, et al.
Published: (2014-01-01) -
Fragment library screening by X-ray crystallography and binding site analysis on thioredoxin glutathione reductase of Schistosoma mansoni
by: Lauro Ribeiro de Souza Neto, et al.
Published: (2024-01-01) -
Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase
by: Justin R. Prigge, et al.
Published: (2017-06-01) -
Characterizing roles for the glutathione reductase, thioredoxin reductase and thioredoxin peroxidase-encoding genes of Magnaporthe oryzae during rice blast disease.
by: Jessie Fernandez, et al.
Published: (2014-01-01) -
Non-covalent inhibitors of thioredoxin glutathione reductase with schistosomicidal activity in vivo
by: Valentina Z. Petukhova, et al.
Published: (2023-06-01)