Association between Inguinal Hernia and Arterial Disease: A Preliminary Report
Background: Inguinal hernia (IH) is a major problem in general surgery and its prevalence is increasing. The presence of hernias has been associated with a wide spectrum of venous diseases, with the involvement of imbalances in collagen and extracellular matrix deposition and metalloproteinases dysf...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-08-01
|
| Series: | Biology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-7737/10/8/736 |
| _version_ | 1797524652645416960 |
|---|---|
| author | Raffaele Serra Umberto Marcello Bracale Rosy Conforto Arturo Roncone Nicola Ielapi Ashour Michael Maurizio Sodo Maria Donata Di Taranto Pasquale Mastroroberto Giuseppe Filiberto Serraino Michele Provenzano Michele Andreucci |
| author_facet | Raffaele Serra Umberto Marcello Bracale Rosy Conforto Arturo Roncone Nicola Ielapi Ashour Michael Maurizio Sodo Maria Donata Di Taranto Pasquale Mastroroberto Giuseppe Filiberto Serraino Michele Provenzano Michele Andreucci |
| author_sort | Raffaele Serra |
| collection | DOAJ |
| description | Background: Inguinal hernia (IH) is a major problem in general surgery and its prevalence is increasing. The presence of hernias has been associated with a wide spectrum of venous diseases, with the involvement of imbalances in collagen and extracellular matrix deposition and metalloproteinases dysfunction. We aimed to evaluate whether the association between IH and vascular diseases is also present with respect to arterial diseases. Methods: We designed a cross-sectional observational study enrolling consecutive patients undergoing surgical repair of IH. Arterial diseases (AD) considered were carotid stenosis, peripheral artery disease and abdominal aortic aneurysms. Results: Study population consisted of 70 patients. Mean age was 63.2 ± 4.7 years. Prevalence of AD was 42.9% in the whole cohort. AD patients were older (<i>p</i> = 0.015), and more frequently had hypertension (<i>p</i> = 0.001) and active smoking habits (<i>p</i> = 0.001) than the no-AD group. Albumin-to-creatinine ratio (ACR) was higher in AD than in no-AD patients (<i>p</i> < 0.001). At multivariable analysis, increased ACR (odds ratio, OR: 1.14, <i>p</i> < 0.001), old age (OR: 1.25, <i>p</i> = 0.001) and a smoking habit (OR: 3.20, <i>p</i> = 0.001) were significant correlates for the presence of AD. Conclusions: Prevalence of AD in patients with IH is non-negligible. Old age, a smoking habit and an abnormal excretion of urine albumin are associated with the presence of AD in these patients. Future studies are needed to gain more insights into the pathogenic mechanisms underlying this association, exploring also the specific role of metalloproteinases. |
| first_indexed | 2024-03-10T09:00:31Z |
| format | Article |
| id | doaj.art-8f8cb76382d34614a15b60fa49bf664f |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-10T09:00:31Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-8f8cb76382d34614a15b60fa49bf664f2023-11-22T06:49:47ZengMDPI AGBiology2079-77372021-08-0110873610.3390/biology10080736Association between Inguinal Hernia and Arterial Disease: A Preliminary ReportRaffaele Serra0Umberto Marcello Bracale1Rosy Conforto2Arturo Roncone3Nicola Ielapi4Ashour Michael5Maurizio Sodo6Maria Donata Di Taranto7Pasquale Mastroroberto8Giuseppe Filiberto Serraino9Michele Provenzano10Michele Andreucci11Interuniversity Center of Phlebolymphology (CIFL), “Magna Graecia” University of Catanzaro, 88100 Catanzaro, ItalyDepartment of Public Health, University of Naples “Federico II”, 80100 Naples, ItalyInteruniversity Center of Phlebolymphology (CIFL), “Magna Graecia” University of Catanzaro, 88100 Catanzaro, ItalyDepartment Surgery, Hospital of Soverato, 88068 Soverato, ItalyDepartment of Public Health and Infectious Disease, “Sapienza” University of Rome, 00185 Rome, ItalyDepartment of Health Sciences, “Magna Graecia” University, 88100 Catanzaro, ItalyDepartment of Public Health, University of Naples “Federico II”, 80100 Naples, ItalyDepartment of Molecular Medicine and Medical Biotechnology, University Federico II of Naples, 80100 Naples, ItalyDepartment of Experimental and Clinical Medicine, University of Catanzaro, 88100 Catanzaro, ItalyDepartment of Experimental and Clinical Medicine, University of Catanzaro, 88100 Catanzaro, ItalyDepartment of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyDepartment of Health Sciences, “Magna Graecia” University, 88100 Catanzaro, ItalyBackground: Inguinal hernia (IH) is a major problem in general surgery and its prevalence is increasing. The presence of hernias has been associated with a wide spectrum of venous diseases, with the involvement of imbalances in collagen and extracellular matrix deposition and metalloproteinases dysfunction. We aimed to evaluate whether the association between IH and vascular diseases is also present with respect to arterial diseases. Methods: We designed a cross-sectional observational study enrolling consecutive patients undergoing surgical repair of IH. Arterial diseases (AD) considered were carotid stenosis, peripheral artery disease and abdominal aortic aneurysms. Results: Study population consisted of 70 patients. Mean age was 63.2 ± 4.7 years. Prevalence of AD was 42.9% in the whole cohort. AD patients were older (<i>p</i> = 0.015), and more frequently had hypertension (<i>p</i> = 0.001) and active smoking habits (<i>p</i> = 0.001) than the no-AD group. Albumin-to-creatinine ratio (ACR) was higher in AD than in no-AD patients (<i>p</i> < 0.001). At multivariable analysis, increased ACR (odds ratio, OR: 1.14, <i>p</i> < 0.001), old age (OR: 1.25, <i>p</i> = 0.001) and a smoking habit (OR: 3.20, <i>p</i> = 0.001) were significant correlates for the presence of AD. Conclusions: Prevalence of AD in patients with IH is non-negligible. Old age, a smoking habit and an abnormal excretion of urine albumin are associated with the presence of AD in these patients. Future studies are needed to gain more insights into the pathogenic mechanisms underlying this association, exploring also the specific role of metalloproteinases.https://www.mdpi.com/2079-7737/10/8/736arterial diseaseinguinal herniavascularcarotidaneurismperipheral artery disease |
| spellingShingle | Raffaele Serra Umberto Marcello Bracale Rosy Conforto Arturo Roncone Nicola Ielapi Ashour Michael Maurizio Sodo Maria Donata Di Taranto Pasquale Mastroroberto Giuseppe Filiberto Serraino Michele Provenzano Michele Andreucci Association between Inguinal Hernia and Arterial Disease: A Preliminary Report Biology arterial disease inguinal hernia vascular carotid aneurism peripheral artery disease |
| title | Association between Inguinal Hernia and Arterial Disease: A Preliminary Report |
| title_full | Association between Inguinal Hernia and Arterial Disease: A Preliminary Report |
| title_fullStr | Association between Inguinal Hernia and Arterial Disease: A Preliminary Report |
| title_full_unstemmed | Association between Inguinal Hernia and Arterial Disease: A Preliminary Report |
| title_short | Association between Inguinal Hernia and Arterial Disease: A Preliminary Report |
| title_sort | association between inguinal hernia and arterial disease a preliminary report |
| topic | arterial disease inguinal hernia vascular carotid aneurism peripheral artery disease |
| url | https://www.mdpi.com/2079-7737/10/8/736 |
| work_keys_str_mv | AT raffaeleserra associationbetweeninguinalherniaandarterialdiseaseapreliminaryreport AT umbertomarcellobracale associationbetweeninguinalherniaandarterialdiseaseapreliminaryreport AT rosyconforto associationbetweeninguinalherniaandarterialdiseaseapreliminaryreport AT arturoroncone associationbetweeninguinalherniaandarterialdiseaseapreliminaryreport AT nicolaielapi associationbetweeninguinalherniaandarterialdiseaseapreliminaryreport AT ashourmichael associationbetweeninguinalherniaandarterialdiseaseapreliminaryreport AT mauriziosodo associationbetweeninguinalherniaandarterialdiseaseapreliminaryreport AT mariadonataditaranto associationbetweeninguinalherniaandarterialdiseaseapreliminaryreport AT pasqualemastroroberto associationbetweeninguinalherniaandarterialdiseaseapreliminaryreport AT giuseppefilibertoserraino associationbetweeninguinalherniaandarterialdiseaseapreliminaryreport AT micheleprovenzano associationbetweeninguinalherniaandarterialdiseaseapreliminaryreport AT micheleandreucci associationbetweeninguinalherniaandarterialdiseaseapreliminaryreport |