Mesenchymal Stem Cell-Derived Long Noncoding RNAs in Cardiac Injury and Repair
Cardiac injury, such as myocardial infarction and heart failure, remains a significant global health burden. The limited regenerative capacity of the adult heart poses a challenge for restoring its function after injury. Mesenchymal stem cells (MSCs) have emerged as promising candidates for cardiac...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/12/18/2268 |
| _version_ | 1797580817366515712 |
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| author | Talan Tran Claudia Cruz Anthony Chan Salma Awad Johnson Rajasingh Richard Deth Narasimman Gurusamy |
| author_facet | Talan Tran Claudia Cruz Anthony Chan Salma Awad Johnson Rajasingh Richard Deth Narasimman Gurusamy |
| author_sort | Talan Tran |
| collection | DOAJ |
| description | Cardiac injury, such as myocardial infarction and heart failure, remains a significant global health burden. The limited regenerative capacity of the adult heart poses a challenge for restoring its function after injury. Mesenchymal stem cells (MSCs) have emerged as promising candidates for cardiac regeneration due to their ability to differentiate into various cell types and secrete bioactive molecules. In recent years, attention has been given to noncoding RNAs derived from MSCs, particularly long noncoding RNAs (lncRNAs), and their potential role in cardiac injury and repair. LncRNAs are RNA molecules that do not encode proteins but play critical roles in gene regulation and cellular responses including cardiac repair and regeneration. This review focused on MSC-derived lncRNAs and their implications in cardiac regeneration, including their effects on cardiac function, myocardial remodeling, cardiomyocyte injury, and angiogenesis. Understanding the molecular mechanisms of MSC-derived lncRNAs in cardiac injury and repair may contribute to the development of novel therapeutic strategies for treating cardiovascular diseases. However, further research is needed to fully elucidate the potential of MSC-derived lncRNAs and address the challenges in this field. |
| first_indexed | 2024-03-10T22:56:25Z |
| format | Article |
| id | doaj.art-8f8e4eda217d42aca30ae03a0d6631d8 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T22:56:25Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-8f8e4eda217d42aca30ae03a0d6631d82023-11-19T09:59:40ZengMDPI AGCells2073-44092023-09-011218226810.3390/cells12182268Mesenchymal Stem Cell-Derived Long Noncoding RNAs in Cardiac Injury and RepairTalan Tran0Claudia Cruz1Anthony Chan2Salma Awad3Johnson Rajasingh4Richard Deth5Narasimman Gurusamy6Department of Pharmaceutical Sciences, Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, 3200 South University Drive, Fort Lauderdale, FL 33328, USADepartment of Pharmaceutical Sciences, Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, 3200 South University Drive, Fort Lauderdale, FL 33328, USADepartment of Pharmaceutical Sciences, Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, 3200 South University Drive, Fort Lauderdale, FL 33328, USADepartment of Pharmaceutical Sciences, Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, 3200 South University Drive, Fort Lauderdale, FL 33328, USADepartment of Bioscience Research, University of Tennessee Health Science Center, 847 Monroe Avenue, Memphis, TN 38163, USADepartment of Pharmaceutical Sciences, Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, 3200 South University Drive, Fort Lauderdale, FL 33328, USADepartment of Pharmaceutical Sciences, Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, 3200 South University Drive, Fort Lauderdale, FL 33328, USACardiac injury, such as myocardial infarction and heart failure, remains a significant global health burden. The limited regenerative capacity of the adult heart poses a challenge for restoring its function after injury. Mesenchymal stem cells (MSCs) have emerged as promising candidates for cardiac regeneration due to their ability to differentiate into various cell types and secrete bioactive molecules. In recent years, attention has been given to noncoding RNAs derived from MSCs, particularly long noncoding RNAs (lncRNAs), and their potential role in cardiac injury and repair. LncRNAs are RNA molecules that do not encode proteins but play critical roles in gene regulation and cellular responses including cardiac repair and regeneration. This review focused on MSC-derived lncRNAs and their implications in cardiac regeneration, including their effects on cardiac function, myocardial remodeling, cardiomyocyte injury, and angiogenesis. Understanding the molecular mechanisms of MSC-derived lncRNAs in cardiac injury and repair may contribute to the development of novel therapeutic strategies for treating cardiovascular diseases. However, further research is needed to fully elucidate the potential of MSC-derived lncRNAs and address the challenges in this field.https://www.mdpi.com/2073-4409/12/18/2268mesenchymal stem cellsexosomenoncoding RNAlong noncoding RNAheart failuremyocardial remodeling |
| spellingShingle | Talan Tran Claudia Cruz Anthony Chan Salma Awad Johnson Rajasingh Richard Deth Narasimman Gurusamy Mesenchymal Stem Cell-Derived Long Noncoding RNAs in Cardiac Injury and Repair Cells mesenchymal stem cells exosome noncoding RNA long noncoding RNA heart failure myocardial remodeling |
| title | Mesenchymal Stem Cell-Derived Long Noncoding RNAs in Cardiac Injury and Repair |
| title_full | Mesenchymal Stem Cell-Derived Long Noncoding RNAs in Cardiac Injury and Repair |
| title_fullStr | Mesenchymal Stem Cell-Derived Long Noncoding RNAs in Cardiac Injury and Repair |
| title_full_unstemmed | Mesenchymal Stem Cell-Derived Long Noncoding RNAs in Cardiac Injury and Repair |
| title_short | Mesenchymal Stem Cell-Derived Long Noncoding RNAs in Cardiac Injury and Repair |
| title_sort | mesenchymal stem cell derived long noncoding rnas in cardiac injury and repair |
| topic | mesenchymal stem cells exosome noncoding RNA long noncoding RNA heart failure myocardial remodeling |
| url | https://www.mdpi.com/2073-4409/12/18/2268 |
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