Potential role of recombinant growth differentiation factor 11 in Alzheimer’s disease treatment
Abstract Alzheimer's disease (AD) is a neurodegenerative disease closely related to the accumulation of beta-amyloid (Aβ) plaques. Growth differentiation factor 11 (GDF11) is one of the proteins that play a role in the aggravation of AD. Decreased concentration of GDF11 disrupts regenerative ne...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-05-01
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| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41983-022-00487-5 |
| _version_ | 1811235490411577344 |
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| author | Bryan Gervais de Liyis Wilson Halim I. Putu Eka Widyadharma |
| author_facet | Bryan Gervais de Liyis Wilson Halim I. Putu Eka Widyadharma |
| author_sort | Bryan Gervais de Liyis |
| collection | DOAJ |
| description | Abstract Alzheimer's disease (AD) is a neurodegenerative disease closely related to the accumulation of beta-amyloid (Aβ) plaques. Growth differentiation factor 11 (GDF11) is one of the proteins that play a role in the aggravation of AD. Decreased concentration of GDF11 disrupts regenerative nervous system, blood vessels, and various vital systems. Low levels of GDF11 with age can be overcome with recombinant GDF11 (rGDF11) to rejuvenate the regenerative effect. Based on research results, rGDF11 enhance the proliferation rate of neuronal precursor cells as well as angiogenesis. rGDF11 can replace lost levels of GDF11, overcome astrogliosis and activation of nerve cell microglia. Therapeutic effect of rGDF11 leads to an improved prognosis in AD patients by neurogenesis and angiogenesis. The prospects of rGDF11 in the treatment of AD have great potential for further research in the future. |
| first_indexed | 2024-04-12T11:52:41Z |
| format | Article |
| id | doaj.art-8f8f60506bbf4e6786321ba2fcd4b06a |
| institution | Directory Open Access Journal |
| issn | 1687-8329 |
| language | English |
| last_indexed | 2024-04-12T11:52:41Z |
| publishDate | 2022-05-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj.art-8f8f60506bbf4e6786321ba2fcd4b06a2022-12-22T03:34:08ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292022-05-015811710.1186/s41983-022-00487-5Potential role of recombinant growth differentiation factor 11 in Alzheimer’s disease treatmentBryan Gervais de Liyis0Wilson Halim1I. Putu Eka Widyadharma2Faculty of Medicine, Udayana UniversityFaculty of Medicine, Udayana UniversityDepartment of Neurology, Faculty of Medicine, Udayana UniversityAbstract Alzheimer's disease (AD) is a neurodegenerative disease closely related to the accumulation of beta-amyloid (Aβ) plaques. Growth differentiation factor 11 (GDF11) is one of the proteins that play a role in the aggravation of AD. Decreased concentration of GDF11 disrupts regenerative nervous system, blood vessels, and various vital systems. Low levels of GDF11 with age can be overcome with recombinant GDF11 (rGDF11) to rejuvenate the regenerative effect. Based on research results, rGDF11 enhance the proliferation rate of neuronal precursor cells as well as angiogenesis. rGDF11 can replace lost levels of GDF11, overcome astrogliosis and activation of nerve cell microglia. Therapeutic effect of rGDF11 leads to an improved prognosis in AD patients by neurogenesis and angiogenesis. The prospects of rGDF11 in the treatment of AD have great potential for further research in the future.https://doi.org/10.1186/s41983-022-00487-5Alzheimer’s diseaseAngiogenesisGDF11Neurogenesis |
| spellingShingle | Bryan Gervais de Liyis Wilson Halim I. Putu Eka Widyadharma Potential role of recombinant growth differentiation factor 11 in Alzheimer’s disease treatment The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Alzheimer’s disease Angiogenesis GDF11 Neurogenesis |
| title | Potential role of recombinant growth differentiation factor 11 in Alzheimer’s disease treatment |
| title_full | Potential role of recombinant growth differentiation factor 11 in Alzheimer’s disease treatment |
| title_fullStr | Potential role of recombinant growth differentiation factor 11 in Alzheimer’s disease treatment |
| title_full_unstemmed | Potential role of recombinant growth differentiation factor 11 in Alzheimer’s disease treatment |
| title_short | Potential role of recombinant growth differentiation factor 11 in Alzheimer’s disease treatment |
| title_sort | potential role of recombinant growth differentiation factor 11 in alzheimer s disease treatment |
| topic | Alzheimer’s disease Angiogenesis GDF11 Neurogenesis |
| url | https://doi.org/10.1186/s41983-022-00487-5 |
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