Diagnostic value of NMO-IgG in demyelinating diseases of central nervous system
<p>The aquaporin 4 (AQP4) plays an important role in the maintenance of transmembrane water transfer, blood-brain barrier (BBB) integrity and homeostasis of central nervous system, and its highly specific autoantibody NMO-IgG has been used as a specific biomarker of neuromyelitis optica. Ho...
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| Format: | Article |
| Language: | English |
| Published: |
Tianjin Huanhu Hospital
2016-09-01
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| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
| Subjects: | |
| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/1456 |
| _version_ | 1818287824941613056 |
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| author | Xiao-min XU You-dong WEI |
| author_facet | Xiao-min XU You-dong WEI |
| author_sort | Xiao-min XU |
| collection | DOAJ |
| description | <p>The aquaporin 4 (AQP4) plays an important role in the maintenance of transmembrane water transfer, blood-brain barrier (BBB) integrity and homeostasis of central nervous system, and its highly specific autoantibody NMO-IgG has been used as a specific biomarker of neuromyelitis optica. However, in recent years, several studies have found that the positive rate in patients with neuromyelitis optica is not 100%, and it even can be detected in some other demyelinating diseases of central nervous system. This paper aims to make a review of the diagnostic value of NMO-IgG in demyelinating diseases of central nervous system, in order to deepen the understanding of this antibody and guide the clinical diagnosis and differential diagnosis on demyelinating diseases of central nervous system.</p><p> </p><p><strong>DOI: </strong>10.3969/j.issn.1672-6731.2016.09.006</p> |
| first_indexed | 2024-12-13T01:46:38Z |
| format | Article |
| id | doaj.art-8f90df8344364ade813463aa6dde6c8e |
| institution | Directory Open Access Journal |
| issn | 1672-6731 |
| language | English |
| last_indexed | 2024-12-13T01:46:38Z |
| publishDate | 2016-09-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj.art-8f90df8344364ade813463aa6dde6c8e2022-12-22T00:03:37ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312016-09-011695765811434Diagnostic value of NMO-IgG in demyelinating diseases of central nervous systemXiao-min XU0You-dong WEI1Department of Neurology, the First Affiliated Hospital of Chongqing Medical University; Chongqing Key Laboratory of Neurology, Chongqing 400016, ChinaDepartment of Neurology, the First Affiliated Hospital of Chongqing Medical University; Chongqing Key Laboratory of Neurology, Chongqing 400016, China<p>The aquaporin 4 (AQP4) plays an important role in the maintenance of transmembrane water transfer, blood-brain barrier (BBB) integrity and homeostasis of central nervous system, and its highly specific autoantibody NMO-IgG has been used as a specific biomarker of neuromyelitis optica. However, in recent years, several studies have found that the positive rate in patients with neuromyelitis optica is not 100%, and it even can be detected in some other demyelinating diseases of central nervous system. This paper aims to make a review of the diagnostic value of NMO-IgG in demyelinating diseases of central nervous system, in order to deepen the understanding of this antibody and guide the clinical diagnosis and differential diagnosis on demyelinating diseases of central nervous system.</p><p> </p><p><strong>DOI: </strong>10.3969/j.issn.1672-6731.2016.09.006</p>http://www.cjcnn.org/index.php/cjcnn/article/view/1456Aquaporin 4Neuromyelitis opticaMultiple sclerosisEncephalomyelitis, acute disseminatedReview |
| spellingShingle | Xiao-min XU You-dong WEI Diagnostic value of NMO-IgG in demyelinating diseases of central nervous system Chinese Journal of Contemporary Neurology and Neurosurgery Aquaporin 4 Neuromyelitis optica Multiple sclerosis Encephalomyelitis, acute disseminated Review |
| title | Diagnostic value of NMO-IgG in demyelinating diseases of central nervous system |
| title_full | Diagnostic value of NMO-IgG in demyelinating diseases of central nervous system |
| title_fullStr | Diagnostic value of NMO-IgG in demyelinating diseases of central nervous system |
| title_full_unstemmed | Diagnostic value of NMO-IgG in demyelinating diseases of central nervous system |
| title_short | Diagnostic value of NMO-IgG in demyelinating diseases of central nervous system |
| title_sort | diagnostic value of nmo igg in demyelinating diseases of central nervous system |
| topic | Aquaporin 4 Neuromyelitis optica Multiple sclerosis Encephalomyelitis, acute disseminated Review |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/1456 |
| work_keys_str_mv | AT xiaominxu diagnosticvalueofnmoiggindemyelinatingdiseasesofcentralnervoussystem AT youdongwei diagnosticvalueofnmoiggindemyelinatingdiseasesofcentralnervoussystem |