Phospholipases in Gliomas: Current Knowledge and Future Perspectives from Bench to Bedside
Phospholipases are essential intermediaries that work as hydrolyzing enzymes of phospholipids (PLs), which represent the most abundant species contributing to the biological membranes of nervous cells of the healthy human brain. They generate different lipid mediators, such as diacylglycerol, phosph...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/5/798 |
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| author | Maria Vittoria Marvi Irene Neri Camilla Evangelisti Giulia Ramazzotti Sofia Asioli Matteo Zoli Diego Mazzatenta Niccolò Neri Luca Morandi Caterina Tonon Raffaele Lodi Enrico Franceschi James A. McCubrey Pann-Ghill Suh Lucia Manzoli Stefano Ratti |
| author_facet | Maria Vittoria Marvi Irene Neri Camilla Evangelisti Giulia Ramazzotti Sofia Asioli Matteo Zoli Diego Mazzatenta Niccolò Neri Luca Morandi Caterina Tonon Raffaele Lodi Enrico Franceschi James A. McCubrey Pann-Ghill Suh Lucia Manzoli Stefano Ratti |
| author_sort | Maria Vittoria Marvi |
| collection | DOAJ |
| description | Phospholipases are essential intermediaries that work as hydrolyzing enzymes of phospholipids (PLs), which represent the most abundant species contributing to the biological membranes of nervous cells of the healthy human brain. They generate different lipid mediators, such as diacylglycerol, phosphatidic acid, lysophosphatidic acid, and arachidonic acid, representing key elements of intra- and inter-cellular signaling and being involved in the regulation of several cellular mechanisms that can promote tumor progression and aggressiveness. In this review, it is summarized the current knowledge about the role of phospholipases in brain tumor progression, focusing on low- and high-grade gliomas, representing promising prognostic or therapeutic targets in cancer therapies due to their influential roles in cell proliferation, migration, growth, and survival. A deeper understanding of the phospholipases-related signaling pathways could be necessary to pave the way for new targeted therapeutic strategies. |
| first_indexed | 2024-03-11T03:54:54Z |
| format | Article |
| id | doaj.art-8f90fbd61b89494abd39e1e1bf4e8a0f |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T03:54:54Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-8f90fbd61b89494abd39e1e1bf4e8a0f2023-11-18T00:39:21ZengMDPI AGBiomolecules2218-273X2023-05-0113579810.3390/biom13050798Phospholipases in Gliomas: Current Knowledge and Future Perspectives from Bench to BedsideMaria Vittoria Marvi0Irene Neri1Camilla Evangelisti2Giulia Ramazzotti3Sofia Asioli4Matteo Zoli5Diego Mazzatenta6Niccolò Neri7Luca Morandi8Caterina Tonon9Raffaele Lodi10Enrico Franceschi11James A. McCubrey12Pann-Ghill Suh13Lucia Manzoli14Stefano Ratti15Cellular Signalling Laboratory, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, 40126 Bologna, ItalyCellular Signalling Laboratory, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, 40126 Bologna, ItalyCellular Signalling Laboratory, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, 40126 Bologna, ItalyCellular Signalling Laboratory, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, 40126 Bologna, ItalyDepartment of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, 40126 Bologna, ItalyDepartment of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, 40126 Bologna, ItalyDepartment of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, 40126 Bologna, ItalyProgramma Neurochirurgia Ipofisi—Pituitary Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, 40124 Bologna, ItalyDepartment of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, 40126 Bologna, ItalyDepartment of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, 40126 Bologna, ItalyDepartment of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, 40126 Bologna, ItalyNervous System Medical Oncology Department, IRCCS Istituto delle Scienze Neurologiche di Bologna, 40139 Bologna, ItalyDepartment of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC 27858, USAKorea Brain Research Institute (KBRI), Daegu 41062, Republic of KoreaCellular Signalling Laboratory, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, 40126 Bologna, ItalyCellular Signalling Laboratory, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, 40126 Bologna, ItalyPhospholipases are essential intermediaries that work as hydrolyzing enzymes of phospholipids (PLs), which represent the most abundant species contributing to the biological membranes of nervous cells of the healthy human brain. They generate different lipid mediators, such as diacylglycerol, phosphatidic acid, lysophosphatidic acid, and arachidonic acid, representing key elements of intra- and inter-cellular signaling and being involved in the regulation of several cellular mechanisms that can promote tumor progression and aggressiveness. In this review, it is summarized the current knowledge about the role of phospholipases in brain tumor progression, focusing on low- and high-grade gliomas, representing promising prognostic or therapeutic targets in cancer therapies due to their influential roles in cell proliferation, migration, growth, and survival. A deeper understanding of the phospholipases-related signaling pathways could be necessary to pave the way for new targeted therapeutic strategies.https://www.mdpi.com/2218-273X/13/5/798phospholipasesbrain tumorsgliomastherapeutic targetprognostic biomarker |
| spellingShingle | Maria Vittoria Marvi Irene Neri Camilla Evangelisti Giulia Ramazzotti Sofia Asioli Matteo Zoli Diego Mazzatenta Niccolò Neri Luca Morandi Caterina Tonon Raffaele Lodi Enrico Franceschi James A. McCubrey Pann-Ghill Suh Lucia Manzoli Stefano Ratti Phospholipases in Gliomas: Current Knowledge and Future Perspectives from Bench to Bedside Biomolecules phospholipases brain tumors gliomas therapeutic target prognostic biomarker |
| title | Phospholipases in Gliomas: Current Knowledge and Future Perspectives from Bench to Bedside |
| title_full | Phospholipases in Gliomas: Current Knowledge and Future Perspectives from Bench to Bedside |
| title_fullStr | Phospholipases in Gliomas: Current Knowledge and Future Perspectives from Bench to Bedside |
| title_full_unstemmed | Phospholipases in Gliomas: Current Knowledge and Future Perspectives from Bench to Bedside |
| title_short | Phospholipases in Gliomas: Current Knowledge and Future Perspectives from Bench to Bedside |
| title_sort | phospholipases in gliomas current knowledge and future perspectives from bench to bedside |
| topic | phospholipases brain tumors gliomas therapeutic target prognostic biomarker |
| url | https://www.mdpi.com/2218-273X/13/5/798 |
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