Emergence of Multidrug-Resistant (MDR) and Extensively Drug- Resistant (XDR) Typhoid Fever in Aligarh, Uttar Pradesh: A Case Series
Salmonella Typhi is a Gram-negative rod which causes enteric fever in humans. The introduction of antibiotics to treat typhoid has considerably improved its outcome, but rising multidrug-resistant (MDR) and extensively drug-resistant (XDR) cases due to injudicious use of antibiotics is a matter of...
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| Format: | Article |
| Language: | English |
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Makhdoomi Printers
2023-06-01
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| Series: | Global Journal of Medicine and Public Health |
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| Online Access: | http://nicpd.ac.in/ojs-/index.php/gjmedph/article/view/3824 |
| _version_ | 1827334207424167936 |
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| author | Mohd Arif Mohd Kashif Ali Mohd Yasir Zubair Nazish |
| author_facet | Mohd Arif Mohd Kashif Ali Mohd Yasir Zubair Nazish |
| author_sort | Mohd Arif |
| collection | DOAJ |
| description |
Salmonella Typhi is a Gram-negative rod which causes enteric fever in humans. The introduction of antibiotics to treat typhoid has considerably improved its outcome, but rising multidrug-resistant (MDR) and extensively drug-resistant (XDR) cases due to injudicious use of antibiotics is a matter of grave concern. This case series presents four cases of XDR typhoid fever from a tertiary care centre in northern India. The patients presented in Pediatrics OPD between June 2022 to August 2022, and were admitted and managed in the Pediatrics ward, Jawaharlal Nehru Medical College, AMU, Aligarh. There were two males and two females with a mean age of 10.5 ± 1.73 years. All the patients presented with fever of more than 10 days duration (median duration of symptom before admission 13 ± 5.74 days, IQR 10.5-20.5) and had been on oral cefixime for enteric fever. But, these patients did not show clinical resolution of fever and other symptoms such as fatigue, weakness etc. After the addition of Azithromycin, patients showed clinical improvement and were subsequently discharged over a period of 6-7 days. We are witnessing rapid emergence of XDR typhi strains across the world particularly in resource limited countries like ours. Azithromycin can be used as safer alternative in both MDR and XDR salmonella bacteremia. Additionally, blood culture should be sent of all suspected patients before start of antibiotics.
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| first_indexed | 2024-03-07T17:49:01Z |
| format | Article |
| id | doaj.art-8f916e2959ae4c70ab42cb392b62de11 |
| institution | Directory Open Access Journal |
| issn | 2277-9604 |
| language | English |
| last_indexed | 2024-03-07T17:49:01Z |
| publishDate | 2023-06-01 |
| publisher | Makhdoomi Printers |
| record_format | Article |
| series | Global Journal of Medicine and Public Health |
| spelling | doaj.art-8f916e2959ae4c70ab42cb392b62de112024-03-02T14:21:00ZengMakhdoomi PrintersGlobal Journal of Medicine and Public Health2277-96042023-06-01123Emergence of Multidrug-Resistant (MDR) and Extensively Drug- Resistant (XDR) Typhoid Fever in Aligarh, Uttar Pradesh: A Case SeriesMohd Arif0Mohd Kashif Ali1Mohd Yasir Zubair2 Nazish3Senior ResidentAssistant Professor Senior Resident, department of Community Medicine, Jawahar Lal Nehru Medical College, AMU, Aligarh Junior Resident Salmonella Typhi is a Gram-negative rod which causes enteric fever in humans. The introduction of antibiotics to treat typhoid has considerably improved its outcome, but rising multidrug-resistant (MDR) and extensively drug-resistant (XDR) cases due to injudicious use of antibiotics is a matter of grave concern. This case series presents four cases of XDR typhoid fever from a tertiary care centre in northern India. The patients presented in Pediatrics OPD between June 2022 to August 2022, and were admitted and managed in the Pediatrics ward, Jawaharlal Nehru Medical College, AMU, Aligarh. There were two males and two females with a mean age of 10.5 ± 1.73 years. All the patients presented with fever of more than 10 days duration (median duration of symptom before admission 13 ± 5.74 days, IQR 10.5-20.5) and had been on oral cefixime for enteric fever. But, these patients did not show clinical resolution of fever and other symptoms such as fatigue, weakness etc. After the addition of Azithromycin, patients showed clinical improvement and were subsequently discharged over a period of 6-7 days. We are witnessing rapid emergence of XDR typhi strains across the world particularly in resource limited countries like ours. Azithromycin can be used as safer alternative in both MDR and XDR salmonella bacteremia. Additionally, blood culture should be sent of all suspected patients before start of antibiotics. http://nicpd.ac.in/ojs-/index.php/gjmedph/article/view/3824Typhoid fever, XDR typhoid fever, MDR typhoid fever, Drug resistant typhoid fever |
| spellingShingle | Mohd Arif Mohd Kashif Ali Mohd Yasir Zubair Nazish Emergence of Multidrug-Resistant (MDR) and Extensively Drug- Resistant (XDR) Typhoid Fever in Aligarh, Uttar Pradesh: A Case Series Global Journal of Medicine and Public Health Typhoid fever, XDR typhoid fever, MDR typhoid fever, Drug resistant typhoid fever |
| title | Emergence of Multidrug-Resistant (MDR) and Extensively Drug- Resistant (XDR) Typhoid Fever in Aligarh, Uttar Pradesh: A Case Series |
| title_full | Emergence of Multidrug-Resistant (MDR) and Extensively Drug- Resistant (XDR) Typhoid Fever in Aligarh, Uttar Pradesh: A Case Series |
| title_fullStr | Emergence of Multidrug-Resistant (MDR) and Extensively Drug- Resistant (XDR) Typhoid Fever in Aligarh, Uttar Pradesh: A Case Series |
| title_full_unstemmed | Emergence of Multidrug-Resistant (MDR) and Extensively Drug- Resistant (XDR) Typhoid Fever in Aligarh, Uttar Pradesh: A Case Series |
| title_short | Emergence of Multidrug-Resistant (MDR) and Extensively Drug- Resistant (XDR) Typhoid Fever in Aligarh, Uttar Pradesh: A Case Series |
| title_sort | emergence of multidrug resistant mdr and extensively drug resistant xdr typhoid fever in aligarh uttar pradesh a case series |
| topic | Typhoid fever, XDR typhoid fever, MDR typhoid fever, Drug resistant typhoid fever |
| url | http://nicpd.ac.in/ojs-/index.php/gjmedph/article/view/3824 |
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