Effects of preparation methods on the characteristics of niosomes
Niosomes are colloidal vesicles that capable of encapsulating drugs as a carrier for drug delivery system. They are formed by self-assembly of a non-ionic surfactant with cholesterol and co-surfactant. In this work, cinnarizine-containing niosomes comprised of sorbitan monostearate (Span® 60), chole...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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University of Huddersfield Press
2019-04-01
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| Series: | British Journal of Pharmacy |
| Subjects: | |
| Online Access: | https://www.bjpharm.org.uk/article/id/616/ |
| _version_ | 1797821777141825536 |
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| author | Amal Ali Elkordy Cheng Shu Chaw Li Key Yeo |
| author_facet | Amal Ali Elkordy Cheng Shu Chaw Li Key Yeo |
| author_sort | Amal Ali Elkordy |
| collection | DOAJ |
| description | Niosomes are colloidal vesicles that capable of encapsulating drugs as a carrier for drug delivery system. They are formed by self-assembly of a non-ionic surfactant with cholesterol and co-surfactant. In this work, cinnarizine-containing niosomes comprised of sorbitan monostearate (Span® 60), cholesterol and co-surfactant (Cremophor® ELP, Cremophor® RH40 or Solutol® HS15) were prepared using conventional thin film hydration and microfluidic methods. Effects on characteristics of niosomes with the presence of poorly water-soluble drug, cinnarizine in the niosomal formulations prepared using different methods and incorporation of different co-surfactants were studied and compared for their particle size, polydispersity index (PDI) and encapsulation efficiency. Dynamic light scattering was employed for particle size measurements and drug loading studies were analysed using high performance liquid chromatography (HPLC). The morphology of niosomes was characterized using optical light microscopy. |
| first_indexed | 2024-03-13T09:57:49Z |
| format | Article |
| id | doaj.art-8f9189f07d8645c0bf64af995c51fc64 |
| institution | Directory Open Access Journal |
| issn | 2058-8356 |
| language | English |
| last_indexed | 2024-03-13T09:57:49Z |
| publishDate | 2019-04-01 |
| publisher | University of Huddersfield Press |
| record_format | Article |
| series | British Journal of Pharmacy |
| spelling | doaj.art-8f9189f07d8645c0bf64af995c51fc642023-05-23T13:42:24ZengUniversity of Huddersfield PressBritish Journal of Pharmacy2058-83562019-04-014110.5920/bjpharm.616Effects of preparation methods on the characteristics of niosomesAmal Ali Elkordy0Cheng Shu Chaw1https://orcid.org/0000-0002-7450-4100Li Key Yeo2University of SunderlandUniversity of SunderlandUniversity of SunderlandNiosomes are colloidal vesicles that capable of encapsulating drugs as a carrier for drug delivery system. They are formed by self-assembly of a non-ionic surfactant with cholesterol and co-surfactant. In this work, cinnarizine-containing niosomes comprised of sorbitan monostearate (Span® 60), cholesterol and co-surfactant (Cremophor® ELP, Cremophor® RH40 or Solutol® HS15) were prepared using conventional thin film hydration and microfluidic methods. Effects on characteristics of niosomes with the presence of poorly water-soluble drug, cinnarizine in the niosomal formulations prepared using different methods and incorporation of different co-surfactants were studied and compared for their particle size, polydispersity index (PDI) and encapsulation efficiency. Dynamic light scattering was employed for particle size measurements and drug loading studies were analysed using high performance liquid chromatography (HPLC). The morphology of niosomes was characterized using optical light microscopy.https://www.bjpharm.org.uk/article/id/616/microfluidicthin film hydrationcinnarizineniosomes |
| spellingShingle | Amal Ali Elkordy Cheng Shu Chaw Li Key Yeo Effects of preparation methods on the characteristics of niosomes British Journal of Pharmacy microfluidic thin film hydration cinnarizine niosomes |
| title | Effects of preparation methods on the characteristics of niosomes |
| title_full | Effects of preparation methods on the characteristics of niosomes |
| title_fullStr | Effects of preparation methods on the characteristics of niosomes |
| title_full_unstemmed | Effects of preparation methods on the characteristics of niosomes |
| title_short | Effects of preparation methods on the characteristics of niosomes |
| title_sort | effects of preparation methods on the characteristics of niosomes |
| topic | microfluidic thin film hydration cinnarizine niosomes |
| url | https://www.bjpharm.org.uk/article/id/616/ |
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