Clathrin light chain A drives selective myosin VI recruitment to clathrin-coated pits under membrane tension
Clathrin light chains (CLCa and CLCb) are major constituents of clathrin-coated vesicles. Here authors find and structurally characterize the selective interaction between CLCa and the actin motor protein myosin VI which act together to generate the force that leads to invagination and fission at th...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-12855-6 |
| _version_ | 1818716780598657024 |
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| author | Matteo Biancospino Gwen R. Buel Carlos A. Niño Elena Maspero Rossella Scotto di Perrotolo Andrea Raimondi Lisa Redlingshöfer Janine Weber Frances M. Brodsky Kylie J. Walters Simona Polo |
| author_facet | Matteo Biancospino Gwen R. Buel Carlos A. Niño Elena Maspero Rossella Scotto di Perrotolo Andrea Raimondi Lisa Redlingshöfer Janine Weber Frances M. Brodsky Kylie J. Walters Simona Polo |
| author_sort | Matteo Biancospino |
| collection | DOAJ |
| description | Clathrin light chains (CLCa and CLCb) are major constituents of clathrin-coated vesicles. Here authors find and structurally characterize the selective interaction between CLCa and the actin motor protein myosin VI which act together to generate the force that leads to invagination and fission at the apical surface. |
| first_indexed | 2024-12-17T19:24:42Z |
| format | Article |
| id | doaj.art-8f91af4c82334c6394eedff499f3dee1 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T19:24:42Z |
| publishDate | 2019-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-8f91af4c82334c6394eedff499f3dee12022-12-21T21:35:25ZengNature PortfolioNature Communications2041-17232019-10-0110111510.1038/s41467-019-12855-6Clathrin light chain A drives selective myosin VI recruitment to clathrin-coated pits under membrane tensionMatteo Biancospino0Gwen R. Buel1Carlos A. Niño2Elena Maspero3Rossella Scotto di Perrotolo4Andrea Raimondi5Lisa Redlingshöfer6Janine Weber7Frances M. Brodsky8Kylie J. Walters9Simona Polo10IFOM, Fondazione Istituto FIRC di Oncologia MolecolareStructural Biophysics Laboratory, Center for Cancer Research, National Cancer InstituteIFOM, Fondazione Istituto FIRC di Oncologia MolecolareIFOM, Fondazione Istituto FIRC di Oncologia MolecolareIFOM, Fondazione Istituto FIRC di Oncologia MolecolareExperimental Imaging Center, San Raffaele Scientific InstituteDivision of Biosciences, University College LondonIFOM, Fondazione Istituto FIRC di Oncologia MolecolareDivision of Biosciences, University College LondonStructural Biophysics Laboratory, Center for Cancer Research, National Cancer InstituteIFOM, Fondazione Istituto FIRC di Oncologia MolecolareClathrin light chains (CLCa and CLCb) are major constituents of clathrin-coated vesicles. Here authors find and structurally characterize the selective interaction between CLCa and the actin motor protein myosin VI which act together to generate the force that leads to invagination and fission at the apical surface.https://doi.org/10.1038/s41467-019-12855-6 |
| spellingShingle | Matteo Biancospino Gwen R. Buel Carlos A. Niño Elena Maspero Rossella Scotto di Perrotolo Andrea Raimondi Lisa Redlingshöfer Janine Weber Frances M. Brodsky Kylie J. Walters Simona Polo Clathrin light chain A drives selective myosin VI recruitment to clathrin-coated pits under membrane tension Nature Communications |
| title | Clathrin light chain A drives selective myosin VI recruitment to clathrin-coated pits under membrane tension |
| title_full | Clathrin light chain A drives selective myosin VI recruitment to clathrin-coated pits under membrane tension |
| title_fullStr | Clathrin light chain A drives selective myosin VI recruitment to clathrin-coated pits under membrane tension |
| title_full_unstemmed | Clathrin light chain A drives selective myosin VI recruitment to clathrin-coated pits under membrane tension |
| title_short | Clathrin light chain A drives selective myosin VI recruitment to clathrin-coated pits under membrane tension |
| title_sort | clathrin light chain a drives selective myosin vi recruitment to clathrin coated pits under membrane tension |
| url | https://doi.org/10.1038/s41467-019-12855-6 |
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