Role of Enzymatic Activity in the Biological Cost Associated with the Production of AmpC β-Lactamases in Pseudomonas aeruginosa

Role of Enzymatic Activity in the Biological Cost Associated with the Production of AmpC β-Lactamases in Pseudomonas aeruginosa

ABSTRACT In the current scenario of growing antibiotic resistance, understanding the interplay between resistance mechanisms and biological costs is crucial for designing therapeutic strategies. In this regard, intrinsic AmpC β-lactamase hyperproduction is probably the most important resistance mech...

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Bibliographic Details
Main Authors: Isabel M. Barceló, Elena Jordana-Lluch, María Escobar-Salom, Gabriel Torrens, Pablo A. Fraile-Ribot, Gabriel Cabot, Xavier Mulet, Laura Zamorano, Carlos Juan, Antonio Oliver
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:Microbiology Spectrum
Subjects:
Pseudomonas aeruginosa
AmpC
ceftolozane-tazobactam
ceftazidime-avibactam
Galleria mellonella
blaFOX β-lactamases
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02700-22

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