Effectiveness of Teriparatide on Fracture Healing: A Systematic Review and Meta-Analysis.
PURPOSE:Nowadays, the efficacy of teriparatide in treating osteoporosis was widely accepted, but the discussion about using teriparatide to enhance fracture healing hasn't come to an agreement. This meta-analysis was conducted to evaluate the effectiveness of teriparatide for fracture healing....
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5173248?pdf=render |
| _version_ | 1819048415708839936 |
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| author | Zhongju Shi Hengxing Zhou Bin Pan Lu Lu Jun Liu Yi Kang Xue Yao Shiqing Feng |
| author_facet | Zhongju Shi Hengxing Zhou Bin Pan Lu Lu Jun Liu Yi Kang Xue Yao Shiqing Feng |
| author_sort | Zhongju Shi |
| collection | DOAJ |
| description | PURPOSE:Nowadays, the efficacy of teriparatide in treating osteoporosis was widely accepted, but the discussion about using teriparatide to enhance fracture healing hasn't come to an agreement. This meta-analysis was conducted to evaluate the effectiveness of teriparatide for fracture healing. METHODS:We searched PubMed, the Cochrane Library, and Embase in August 2016 for randomized controlled trials (RCTs) which concerned the treatment of teriparatide for fracture healing. RESULTS:Finally, a total of 380 patients were randomly assigned in the 5 trials included in this meta-analysis. There was a significant effectiveness with regards to function improvement in patients following fracture, however, there was no significant effectiveness with regards to time of radiographic fracture healing, fracture healing rate and reduction in pain. CONCLUSIONS:This analysis showed that administration of teriparatide following fracture lacked the effectiveness for fracture healing. Moreover, teriparatide administration had no apparent adverse effects. These results should be interpreted with caution because of some clear limitations. If we want to confirm whether teriparatide improves fracture healing, more high-quality randomized controlled trials are needed. |
| first_indexed | 2024-12-21T11:15:54Z |
| format | Article |
| id | doaj.art-8f92943f0c694e7681c6771dacda158f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T11:15:54Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-8f92943f0c694e7681c6771dacda158f2022-12-21T19:05:56ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011112e016869110.1371/journal.pone.0168691Effectiveness of Teriparatide on Fracture Healing: A Systematic Review and Meta-Analysis.Zhongju ShiHengxing ZhouBin PanLu LuJun LiuYi KangXue YaoShiqing FengPURPOSE:Nowadays, the efficacy of teriparatide in treating osteoporosis was widely accepted, but the discussion about using teriparatide to enhance fracture healing hasn't come to an agreement. This meta-analysis was conducted to evaluate the effectiveness of teriparatide for fracture healing. METHODS:We searched PubMed, the Cochrane Library, and Embase in August 2016 for randomized controlled trials (RCTs) which concerned the treatment of teriparatide for fracture healing. RESULTS:Finally, a total of 380 patients were randomly assigned in the 5 trials included in this meta-analysis. There was a significant effectiveness with regards to function improvement in patients following fracture, however, there was no significant effectiveness with regards to time of radiographic fracture healing, fracture healing rate and reduction in pain. CONCLUSIONS:This analysis showed that administration of teriparatide following fracture lacked the effectiveness for fracture healing. Moreover, teriparatide administration had no apparent adverse effects. These results should be interpreted with caution because of some clear limitations. If we want to confirm whether teriparatide improves fracture healing, more high-quality randomized controlled trials are needed.http://europepmc.org/articles/PMC5173248?pdf=render |
| spellingShingle | Zhongju Shi Hengxing Zhou Bin Pan Lu Lu Jun Liu Yi Kang Xue Yao Shiqing Feng Effectiveness of Teriparatide on Fracture Healing: A Systematic Review and Meta-Analysis. PLoS ONE |
| title | Effectiveness of Teriparatide on Fracture Healing: A Systematic Review and Meta-Analysis. |
| title_full | Effectiveness of Teriparatide on Fracture Healing: A Systematic Review and Meta-Analysis. |
| title_fullStr | Effectiveness of Teriparatide on Fracture Healing: A Systematic Review and Meta-Analysis. |
| title_full_unstemmed | Effectiveness of Teriparatide on Fracture Healing: A Systematic Review and Meta-Analysis. |
| title_short | Effectiveness of Teriparatide on Fracture Healing: A Systematic Review and Meta-Analysis. |
| title_sort | effectiveness of teriparatide on fracture healing a systematic review and meta analysis |
| url | http://europepmc.org/articles/PMC5173248?pdf=render |
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