Micron-Scale NV-NMR Spectroscopy with Signal Amplification by Reversible Exchange

Micron-Scale NV-NMR Spectroscopy with Signal Amplification by Reversible Exchange

Optically probed nitrogen-vacancy (NV)) quantum defects in diamond can detect nuclear magnetic resonance (NMR) signals with high-spectral resolution from micron-scale sample volumes of about 10 pl. However, a key challenge for NV-NMR spectroscopy is detecting samples at millimolar concentrations. He...

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Bibliographic Details
Main Authors: Nithya Arunkumar, Dominik B. Bucher, Matthew J. Turner, Patrick TomHon, David Glenn, Sören Lehmkuhl, Mikhail D. Lukin, Hongkun Park, Matthew S. Rosen, Thomas Theis, Ronald L. Walsworth
Format: Article
Language:English
Published: American Physical Society 2021-01-01
Series:PRX Quantum
Online Access:http://doi.org/10.1103/PRXQuantum.2.010305
Description
Summary:Optically probed nitrogen-vacancy (NV)) quantum defects in diamond can detect nuclear magnetic resonance (NMR) signals with high-spectral resolution from micron-scale sample volumes of about 10 pl. However, a key challenge for NV-NMR spectroscopy is detecting samples at millimolar concentrations. Here we demonstrate an increase in NV-NMR proton concentration sensitivity by hyperpolarizing sample proton spins to about 0.5% through signal amplification by reversible exchange (SABRE), enabling micron-scale NMR spectroscopy of small-molecule sample concentrations as low as 1 mM in picoliter volumes. The SABRE-enhanced NV-NMR technique may enable detection and chemical analysis of low-concentration molecules and their dynamics in complex micron-scale systems such as single cells.
ISSN:2691-3399

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