A Novel Bromophenol Derivative BOS-102 Induces Cell Cycle Arrest and Apoptosis in Human A549 Lung Cancer Cells via ROS-Mediated PI3K/Akt and the MAPK Signaling Pathway

A Novel Bromophenol Derivative BOS-102 Induces Cell Cycle Arrest and Apoptosis in Human A549 Lung Cancer Cells via ROS-Mediated PI3K/Akt and the MAPK Signaling Pathway

Bromophenol is a type of natural marine product. It has excellent biological activities, especially anticancer activities. In our study of searching for potent anticancer drugs, a novel bromophenol derivative containing indolin-2-one moiety, 3-(4-(3-([1,4′-bipiperidin]-1′-yl)propoxy)-3-bromo-5-metho...

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Bibliographic Details
Main Authors: Chuan-Long Guo, Li-Jun Wang, Yue Zhao, Hua Liu, Xiang-Qian Li, Bo Jiang, Jiao Luo, Shu-Ju Guo, Ning Wu, Da-Yong Shi
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:Marine Drugs
Subjects:
bromophenol
molecular mechanisms
apoptosis
cell cycle
PI3K/Akt
p38/ERK
ROS
human lung cancer
Online Access:http://www.mdpi.com/1660-3397/16/2/43

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