Outcomes of patients with haematological malignancies and febrile neutropenia at the Universitas Academic Hospital multidisciplinary intensive care unit, Free State Province, South Africa
Background. Mortality rates in patients with haematological malignancies who required intensive care unit (ICU) admission have in the past been high. More recently, however, improved outcomes for critically ill haematological patients have been reported. Objective. To determine outcomes, average...
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| Format: | Article |
| Language: | English |
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South African Medical Association
2023-04-01
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| Series: | African Journal of Thoracic and Critical Care Medicine |
| Subjects: | |
| Online Access: | https://samajournals.co.za/index.php/ajtccm/article/view/964 |
| _version_ | 1797328395859656704 |
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| author | C D S Martins S D Maasdorp |
| author_facet | C D S Martins S D Maasdorp |
| author_sort | C D S Martins |
| collection | DOAJ |
| description | Background. Mortality rates in patients with haematological malignancies who required intensive care unit (ICU) admission have in the past been high. More recently, however, improved outcomes for critically ill haematological patients have been reported.
Objective. To determine outcomes, average length of ICU stay, and factors associated with mortality in patients with haematological malignancies and neutropenic fever in the multidisciplinary ICU (MICU) at Universitas Academic Hospital (UAH), Bloemfontein, Free State Province, South Africa.
Methods. We conducted a retrospective review of medical and laboratory records of all patients admitted to the UAH MICU with haematological malignancies and febrile neutropenia between 2010 and 2019.
Results. A total of 182 patients with haematological malignancies were admitted to the MICU between 1 January 2010 and 31 December 2019, of whom 51 (28.0%) fulfilled the inclusion criteria for the study. The median age was 33 years, and 29 patients (56.9%) were female. Most patients had either acute myeloid leukaemia (n=22; 43.1%) or acute lymphocytic leukaemia (n=16; 31.4%), while B-cell lymphoma (n=12; 23.5%) and multiple myeloma (n=1; 2%) were less frequent. The median length of stay in the ICU was 3 days. ICU mortality was 76.5% and hospital mortality 82.4%. Factors associated with mortality included septic shock, vasoactive agent use and mechanical ventilation.
Conclusion. Patients with haematological malignancies and febrile neutropenia in the UAH MICU have high ICU and hospital mortality rates. More needs to be done with regard to timeous management of patients with haematological malignancies and septic shock in our setting to improve survival. |
| first_indexed | 2024-03-08T06:51:14Z |
| format | Article |
| id | doaj.art-8f9753787bbf496899353b5d21a1714d |
| institution | Directory Open Access Journal |
| issn | 2617-0191 2617-0205 |
| language | English |
| last_indexed | 2024-03-08T06:51:14Z |
| publishDate | 2023-04-01 |
| publisher | South African Medical Association |
| record_format | Article |
| series | African Journal of Thoracic and Critical Care Medicine |
| spelling | doaj.art-8f9753787bbf496899353b5d21a1714d2024-02-03T06:50:05ZengSouth African Medical AssociationAfrican Journal of Thoracic and Critical Care Medicine2617-01912617-02052023-04-01182310.7196/AJTCCM.2023.v29i1.263969Outcomes of patients with haematological malignancies and febrile neutropenia at the Universitas Academic Hospital multidisciplinary intensive care unit, Free State Province, South AfricaC D S Martins0S D Maasdorp1Division of Critical Care, Department of Surgery, Faculty of Health Sciences, University of the Free State, Bloemfontein, South AfricaDivision of Critical Care, Department of Surgery, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa; Division of Pulmonology, Department of Internal Medicine, Faculty of Health Sciences, University of the Free State, Bloemfontein, South AfricaBackground. Mortality rates in patients with haematological malignancies who required intensive care unit (ICU) admission have in the past been high. More recently, however, improved outcomes for critically ill haematological patients have been reported. Objective. To determine outcomes, average length of ICU stay, and factors associated with mortality in patients with haematological malignancies and neutropenic fever in the multidisciplinary ICU (MICU) at Universitas Academic Hospital (UAH), Bloemfontein, Free State Province, South Africa. Methods. We conducted a retrospective review of medical and laboratory records of all patients admitted to the UAH MICU with haematological malignancies and febrile neutropenia between 2010 and 2019. Results. A total of 182 patients with haematological malignancies were admitted to the MICU between 1 January 2010 and 31 December 2019, of whom 51 (28.0%) fulfilled the inclusion criteria for the study. The median age was 33 years, and 29 patients (56.9%) were female. Most patients had either acute myeloid leukaemia (n=22; 43.1%) or acute lymphocytic leukaemia (n=16; 31.4%), while B-cell lymphoma (n=12; 23.5%) and multiple myeloma (n=1; 2%) were less frequent. The median length of stay in the ICU was 3 days. ICU mortality was 76.5% and hospital mortality 82.4%. Factors associated with mortality included septic shock, vasoactive agent use and mechanical ventilation. Conclusion. Patients with haematological malignancies and febrile neutropenia in the UAH MICU have high ICU and hospital mortality rates. More needs to be done with regard to timeous management of patients with haematological malignancies and septic shock in our setting to improve survival.https://samajournals.co.za/index.php/ajtccm/article/view/964haematological malignanciesneutropenic feversepsisintensive care unit |
| spellingShingle | C D S Martins S D Maasdorp Outcomes of patients with haematological malignancies and febrile neutropenia at the Universitas Academic Hospital multidisciplinary intensive care unit, Free State Province, South Africa African Journal of Thoracic and Critical Care Medicine haematological malignancies neutropenic fever sepsis intensive care unit |
| title | Outcomes of patients with haematological malignancies and febrile neutropenia at the Universitas Academic Hospital multidisciplinary intensive care unit, Free State Province, South Africa |
| title_full | Outcomes of patients with haematological malignancies and febrile neutropenia at the Universitas Academic Hospital multidisciplinary intensive care unit, Free State Province, South Africa |
| title_fullStr | Outcomes of patients with haematological malignancies and febrile neutropenia at the Universitas Academic Hospital multidisciplinary intensive care unit, Free State Province, South Africa |
| title_full_unstemmed | Outcomes of patients with haematological malignancies and febrile neutropenia at the Universitas Academic Hospital multidisciplinary intensive care unit, Free State Province, South Africa |
| title_short | Outcomes of patients with haematological malignancies and febrile neutropenia at the Universitas Academic Hospital multidisciplinary intensive care unit, Free State Province, South Africa |
| title_sort | outcomes of patients with haematological malignancies and febrile neutropenia at the universitas academic hospital multidisciplinary intensive care unit free state province south africa |
| topic | haematological malignancies neutropenic fever sepsis intensive care unit |
| url | https://samajournals.co.za/index.php/ajtccm/article/view/964 |
| work_keys_str_mv | AT cdsmartins outcomesofpatientswithhaematologicalmalignanciesandfebrileneutropeniaattheuniversitasacademichospitalmultidisciplinaryintensivecareunitfreestateprovincesouthafrica AT sdmaasdorp outcomesofpatientswithhaematologicalmalignanciesandfebrileneutropeniaattheuniversitasacademichospitalmultidisciplinaryintensivecareunitfreestateprovincesouthafrica |