Anti-tumor Study of Chondroitin Sulfate-Methotrexate Nanogels

Anti-tumor Study of Chondroitin Sulfate-Methotrexate Nanogels

Abstract Self-assembly nanogels (NGs) were formed by bioconjugating methotrexate (MTX) with chondroitin sulfate (CS). MTX-CS NGs can greatly enhance the solubility and improve the delivery efficacy of MTX due to the CD44 binding property of CS. Vivo experiments revealed that MTX-CS NGs showed less t...

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Bibliographic Details
Main Authors: Jinyu Wang, Weibo Zhao, Haixiao Chen, An Qin, Peizhi Zhu
Format: Article
Language:English
Published: SpringerOpen 2017-10-01
Series:Nanoscale Research Letters
Subjects:
Methotrexate
Chondroitin sulfate
Self-assembly
Nanogels
Anti-tumor
Nanomedicine
Online Access:http://link.springer.com/article/10.1186/s11671-017-2324-1

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