So close, yet so far away: the relationship between MAM and cardiac disease
Mitochondria-associated membrane (MAM) serve as crucial contact sites between mitochondria and the endoplasmic reticulum (ER). Recent research has highlighted the significance of MAM, which serve as a platform for various protein molecules, in processes such as calcium signaling, ATP production, mit...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1353533/full |
| _version_ | 1797324347300380672 |
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| author | Bo Lu Bo Lu Xiaozhe Chen Xiaozhe Chen Yulong Ma Mingtai Gui Lei Yao Jianhua Li Mingzhu Wang Xunjie Zhou Xunjie Zhou Deyu Fu Deyu Fu |
| author_facet | Bo Lu Bo Lu Xiaozhe Chen Xiaozhe Chen Yulong Ma Mingtai Gui Lei Yao Jianhua Li Mingzhu Wang Xunjie Zhou Xunjie Zhou Deyu Fu Deyu Fu |
| author_sort | Bo Lu |
| collection | DOAJ |
| description | Mitochondria-associated membrane (MAM) serve as crucial contact sites between mitochondria and the endoplasmic reticulum (ER). Recent research has highlighted the significance of MAM, which serve as a platform for various protein molecules, in processes such as calcium signaling, ATP production, mitochondrial structure and function, and autophagy. Cardiac diseases caused by any reason can lead to changes in myocardial structure and function, significantly impacting human health. Notably, MAM exhibits various regulatory effects to maintain cellular balance in several cardiac diseases conditions, such as obesity, diabetes mellitus, and cardiotoxicity. MAM proteins independently or interact with their counterparts, forming essential tethers between the ER and mitochondria in cardiomyocytes. This review provides an overview of key MAM regulators, detailing their structure and functions. Additionally, it explores the connection between MAM and various cardiac injuries, suggesting that precise genetic, pharmacological, and physical regulation of MAM may be a promising strategy for preventing and treating heart failure. |
| first_indexed | 2024-03-08T05:54:50Z |
| format | Article |
| id | doaj.art-8f992b2a70e34065946fbd82984da4a9 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-08T05:54:50Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-8f992b2a70e34065946fbd82984da4a92024-02-05T04:45:42ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2024-02-011110.3389/fcvm.2024.13535331353533So close, yet so far away: the relationship between MAM and cardiac diseaseBo Lu0Bo Lu1Xiaozhe Chen2Xiaozhe Chen3Yulong Ma4Mingtai Gui5Lei Yao6Jianhua Li7Mingzhu Wang8Xunjie Zhou9Xunjie Zhou10Deyu Fu11Deyu Fu12Department of Cardiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, United StatesDepartment of Cardiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaShanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Cardiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Cardiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Cardiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Cardiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Cardiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Cardiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaShanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Cardiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaShanghai University of Traditional Chinese Medicine, Shanghai, ChinaMitochondria-associated membrane (MAM) serve as crucial contact sites between mitochondria and the endoplasmic reticulum (ER). Recent research has highlighted the significance of MAM, which serve as a platform for various protein molecules, in processes such as calcium signaling, ATP production, mitochondrial structure and function, and autophagy. Cardiac diseases caused by any reason can lead to changes in myocardial structure and function, significantly impacting human health. Notably, MAM exhibits various regulatory effects to maintain cellular balance in several cardiac diseases conditions, such as obesity, diabetes mellitus, and cardiotoxicity. MAM proteins independently or interact with their counterparts, forming essential tethers between the ER and mitochondria in cardiomyocytes. This review provides an overview of key MAM regulators, detailing their structure and functions. Additionally, it explores the connection between MAM and various cardiac injuries, suggesting that precise genetic, pharmacological, and physical regulation of MAM may be a promising strategy for preventing and treating heart failure.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1353533/fullmitochondria-associated membranecardiac diseaseCa2+ homeostasisapoptosisautophagy |
| spellingShingle | Bo Lu Bo Lu Xiaozhe Chen Xiaozhe Chen Yulong Ma Mingtai Gui Lei Yao Jianhua Li Mingzhu Wang Xunjie Zhou Xunjie Zhou Deyu Fu Deyu Fu So close, yet so far away: the relationship between MAM and cardiac disease Frontiers in Cardiovascular Medicine mitochondria-associated membrane cardiac disease Ca2+ homeostasis apoptosis autophagy |
| title | So close, yet so far away: the relationship between MAM and cardiac disease |
| title_full | So close, yet so far away: the relationship between MAM and cardiac disease |
| title_fullStr | So close, yet so far away: the relationship between MAM and cardiac disease |
| title_full_unstemmed | So close, yet so far away: the relationship between MAM and cardiac disease |
| title_short | So close, yet so far away: the relationship between MAM and cardiac disease |
| title_sort | so close yet so far away the relationship between mam and cardiac disease |
| topic | mitochondria-associated membrane cardiac disease Ca2+ homeostasis apoptosis autophagy |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1353533/full |
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