Pavlovian to Instrumental Transfer Responses Do Not Correlate With Addiction-Like Behavior in Rats
Pavlovian learning plays a prominent role in the etiology of addiction. The influence of Pavlovian conditioning on the expression of an instrumental response can be studied using the Pavlovian-to-instrumental transfer (PIT) paradigm. This paradigm consists of independent Pavlovian conditioning and i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-06-01
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| Series: | Frontiers in Behavioral Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnbeh.2019.00129/full |
| _version_ | 1831764669162848256 |
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| author | Tatiane T. Takahashi Valentina Vengeliene Thomas Enkel Sara Reithofer Rainer Spanagel |
| author_facet | Tatiane T. Takahashi Valentina Vengeliene Thomas Enkel Sara Reithofer Rainer Spanagel |
| author_sort | Tatiane T. Takahashi |
| collection | DOAJ |
| description | Pavlovian learning plays a prominent role in the etiology of addiction. The influence of Pavlovian conditioning on the expression of an instrumental response can be studied using the Pavlovian-to-instrumental transfer (PIT) paradigm. This paradigm consists of independent Pavlovian conditioning and instrumental training prior to the combination of both during the test. During this test, the reward is not available, and an increase in the instrumental responding during conditioned stimuli presentation is a measure of PIT. Recent studies have reported a higher PIT in alcohol and nicotine dependent patients, suggesting that enhanced PIT might be a marker for dependence vulnerability. However, these studies did not use standard PIT procedures, and a clear correlation between an enhanced PIT and drug-related and addictive behaviors has so far not been demonstrated. For a systematic evaluation rats were trained in a cocaine addiction model. Addicted-like and non-addicted-like rats were subsequently assessed in the PIT paradigm. In a further experiment, rats were first tested in the PIT paradigm and thereafter subjected to cocaine self-administration (CSA) training. Our results revealed that addicted-like rats did not differ from non-addicted-like in their performance in the PIT test. However, CSA behavior showed a positive correlation with PIT. This data suggests that stronger PIT may predict higher motivational impact of conditioned stimuli on drug self-administration and improved learning of drug-cue association rather than the risk to develop addiction as such. |
| first_indexed | 2024-12-22T05:47:53Z |
| format | Article |
| id | doaj.art-8f9a99402cb34563873ee8faf7a16e79 |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-22T05:47:53Z |
| publishDate | 2019-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-8f9a99402cb34563873ee8faf7a16e792022-12-21T18:36:57ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532019-06-011310.3389/fnbeh.2019.00129449924Pavlovian to Instrumental Transfer Responses Do Not Correlate With Addiction-Like Behavior in RatsTatiane T. Takahashi0Valentina Vengeliene1Thomas Enkel2Sara Reithofer3Rainer Spanagel4Institute of Psychopharmacology, Central Institute of Mental Health (CIMH), Heidelberg University, Faculty of Medicine Mannheim, Mannheim, GermanyInstitute of Psychopharmacology, Central Institute of Mental Health (CIMH), Heidelberg University, Faculty of Medicine Mannheim, Mannheim, GermanyFaculty of Medicine Mannheim, Department of Molecular Biology, Central Institute of Mental Health, Heidelberg University, Mannheim, GermanyInstitute of Psychopharmacology, Central Institute of Mental Health (CIMH), Heidelberg University, Faculty of Medicine Mannheim, Mannheim, GermanyInstitute of Psychopharmacology, Central Institute of Mental Health (CIMH), Heidelberg University, Faculty of Medicine Mannheim, Mannheim, GermanyPavlovian learning plays a prominent role in the etiology of addiction. The influence of Pavlovian conditioning on the expression of an instrumental response can be studied using the Pavlovian-to-instrumental transfer (PIT) paradigm. This paradigm consists of independent Pavlovian conditioning and instrumental training prior to the combination of both during the test. During this test, the reward is not available, and an increase in the instrumental responding during conditioned stimuli presentation is a measure of PIT. Recent studies have reported a higher PIT in alcohol and nicotine dependent patients, suggesting that enhanced PIT might be a marker for dependence vulnerability. However, these studies did not use standard PIT procedures, and a clear correlation between an enhanced PIT and drug-related and addictive behaviors has so far not been demonstrated. For a systematic evaluation rats were trained in a cocaine addiction model. Addicted-like and non-addicted-like rats were subsequently assessed in the PIT paradigm. In a further experiment, rats were first tested in the PIT paradigm and thereafter subjected to cocaine self-administration (CSA) training. Our results revealed that addicted-like rats did not differ from non-addicted-like in their performance in the PIT test. However, CSA behavior showed a positive correlation with PIT. This data suggests that stronger PIT may predict higher motivational impact of conditioned stimuli on drug self-administration and improved learning of drug-cue association rather than the risk to develop addiction as such.https://www.frontiersin.org/article/10.3389/fnbeh.2019.00129/fullcocaine self-administration0/3-criteria rat model of cocaine addictionoutcome-specific PITgeneral PITrelapse |
| spellingShingle | Tatiane T. Takahashi Valentina Vengeliene Thomas Enkel Sara Reithofer Rainer Spanagel Pavlovian to Instrumental Transfer Responses Do Not Correlate With Addiction-Like Behavior in Rats Frontiers in Behavioral Neuroscience cocaine self-administration 0/3-criteria rat model of cocaine addiction outcome-specific PIT general PIT relapse |
| title | Pavlovian to Instrumental Transfer Responses Do Not Correlate With Addiction-Like Behavior in Rats |
| title_full | Pavlovian to Instrumental Transfer Responses Do Not Correlate With Addiction-Like Behavior in Rats |
| title_fullStr | Pavlovian to Instrumental Transfer Responses Do Not Correlate With Addiction-Like Behavior in Rats |
| title_full_unstemmed | Pavlovian to Instrumental Transfer Responses Do Not Correlate With Addiction-Like Behavior in Rats |
| title_short | Pavlovian to Instrumental Transfer Responses Do Not Correlate With Addiction-Like Behavior in Rats |
| title_sort | pavlovian to instrumental transfer responses do not correlate with addiction like behavior in rats |
| topic | cocaine self-administration 0/3-criteria rat model of cocaine addiction outcome-specific PIT general PIT relapse |
| url | https://www.frontiersin.org/article/10.3389/fnbeh.2019.00129/full |
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