Infectious Bronchitis Virus Nsp14 Degrades JAK1 to Inhibit the JAK-STAT Signaling Pathway in HD11 Cells

Infectious Bronchitis Virus Nsp14 Degrades JAK1 to Inhibit the JAK-STAT Signaling Pathway in HD11 Cells

Coronaviruses (CoVs) are RNA viruses that can infect a wide range of animals, including humans, and cause severe respiratory and gastrointestinal disease. The Gammacoronavirus avian infectious bronchitis virus (IBV) causes acute and contagious diseases in chickens, leading to severe economic losses....

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Bibliographic Details
Main Authors: Peng Ma, Kui Gu, Hao Li, Yu Zhao, Chao Li, Renqiao Wen, Changyu Zhou, Changwei Lei, Xin Yang, Hongning Wang
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Viruses
Subjects:
infectious bronchitis virus (IBV)
nonstructural protein 14 (Nsp14)
IFN-γ
Janus kinase 1 (JAK1)
JAK-STAT signaling pathway
Online Access:https://www.mdpi.com/1999-4915/14/5/1045

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