Cordycepin exacerbates cadmium-induced neurotoxicity via promoting endoplasmic reticulum stress-associated apoptosis
Cordycepin (Cor) is a potent bioactive constituent of Cordyceps militaris, which has been used as a daily tonic food and herbal medicine in Asia. Cadmium (Cd) is a widespread neurotoxic environmental contaminant, and it has been detected as a pollutant in Cordyceps militaris. However, the potential...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-02-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622000056 |
| _version_ | 1798031285186199552 |
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| author | Ke Du Xi Zheng Junya Lv Xin Zhong Minjie Wei Mingyan Liu |
| author_facet | Ke Du Xi Zheng Junya Lv Xin Zhong Minjie Wei Mingyan Liu |
| author_sort | Ke Du |
| collection | DOAJ |
| description | Cordycepin (Cor) is a potent bioactive constituent of Cordyceps militaris, which has been used as a daily tonic food and herbal medicine in Asia. Cadmium (Cd) is a widespread neurotoxic environmental contaminant, and it has been detected as a pollutant in Cordyceps militaris. However, the potential effects of Cor on Cd neurotoxicity remains unknown. This study aimed to investigate the effects and possible mechanisms of Cor on neurotoxicity in Cd-induced cell and preclinical models. It was observed that Cor administration aggravated Cd-induced cognitive impairment and neurotoxicity in mice, exerted synergistic growth inhibition, and promoted apoptosis of SH-SY5Y cells. These effects were found to be mediated through the activation of endoplasmic reticulum (ER) stress. Overall, our findings suggest that Cor can increase Cd-induced neurotoxicity via promoting ER stress-associated apoptosis. These observations may support the implementation of stricter criterion for the detection of Cd in Cordyceps militaris, to keep the consumers safe. |
| first_indexed | 2024-04-11T19:54:59Z |
| format | Article |
| id | doaj.art-8f9b5d5e2ec04f5ea76bea717be61d7f |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-11T19:54:59Z |
| publishDate | 2022-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-8f9b5d5e2ec04f5ea76bea717be61d7f2022-12-22T04:06:12ZengElsevierJournal of Functional Foods1756-46462022-02-0189104935Cordycepin exacerbates cadmium-induced neurotoxicity via promoting endoplasmic reticulum stress-associated apoptosisKe Du0Xi Zheng1Junya Lv2Xin Zhong3Minjie Wei4Mingyan Liu5School of Pharmacy, Department of Pharmacology, China Medical University, Shenyang, Liaoning, China; Liaoning Key Laboratory of Molecular Targeted Anti-tumor Drug Development and Evaluation, Shenyang, Liaoning, ChinaSchool of Pharmacy, Department of Pharmacology, China Medical University, Shenyang, Liaoning, China; Liaoning Key Laboratory of Molecular Targeted Anti-tumor Drug Development and Evaluation, Shenyang, Liaoning, ChinaSchool of Pharmacy, Department of Pharmacology, China Medical University, Shenyang, Liaoning, China; Liaoning Key Laboratory of Molecular Targeted Anti-tumor Drug Development and Evaluation, Shenyang, Liaoning, ChinaSchool of Pharmacy, Department of Pharmacology, China Medical University, Shenyang, Liaoning, China; Liaoning Key Laboratory of Molecular Targeted Anti-tumor Drug Development and Evaluation, Shenyang, Liaoning, ChinaSchool of Pharmacy, Department of Pharmacology, China Medical University, Shenyang, Liaoning, China; Liaoning Key Laboratory of Molecular Targeted Anti-tumor Drug Development and Evaluation, Shenyang, Liaoning, ChinaCorresponding author at: No.77 of Puhe Road, Shenyang North New Area, Shenyang, Liaoning Province 110122, China.; School of Pharmacy, Department of Pharmacology, China Medical University, Shenyang, Liaoning, China; Liaoning Key Laboratory of Molecular Targeted Anti-tumor Drug Development and Evaluation, Shenyang, Liaoning, ChinaCordycepin (Cor) is a potent bioactive constituent of Cordyceps militaris, which has been used as a daily tonic food and herbal medicine in Asia. Cadmium (Cd) is a widespread neurotoxic environmental contaminant, and it has been detected as a pollutant in Cordyceps militaris. However, the potential effects of Cor on Cd neurotoxicity remains unknown. This study aimed to investigate the effects and possible mechanisms of Cor on neurotoxicity in Cd-induced cell and preclinical models. It was observed that Cor administration aggravated Cd-induced cognitive impairment and neurotoxicity in mice, exerted synergistic growth inhibition, and promoted apoptosis of SH-SY5Y cells. These effects were found to be mediated through the activation of endoplasmic reticulum (ER) stress. Overall, our findings suggest that Cor can increase Cd-induced neurotoxicity via promoting ER stress-associated apoptosis. These observations may support the implementation of stricter criterion for the detection of Cd in Cordyceps militaris, to keep the consumers safe.http://www.sciencedirect.com/science/article/pii/S1756464622000056CadmiumCordycepinEndoplasmic reticulum stressApoptosisNeurotoxicityFood safety |
| spellingShingle | Ke Du Xi Zheng Junya Lv Xin Zhong Minjie Wei Mingyan Liu Cordycepin exacerbates cadmium-induced neurotoxicity via promoting endoplasmic reticulum stress-associated apoptosis Journal of Functional Foods Cadmium Cordycepin Endoplasmic reticulum stress Apoptosis Neurotoxicity Food safety |
| title | Cordycepin exacerbates cadmium-induced neurotoxicity via promoting endoplasmic reticulum stress-associated apoptosis |
| title_full | Cordycepin exacerbates cadmium-induced neurotoxicity via promoting endoplasmic reticulum stress-associated apoptosis |
| title_fullStr | Cordycepin exacerbates cadmium-induced neurotoxicity via promoting endoplasmic reticulum stress-associated apoptosis |
| title_full_unstemmed | Cordycepin exacerbates cadmium-induced neurotoxicity via promoting endoplasmic reticulum stress-associated apoptosis |
| title_short | Cordycepin exacerbates cadmium-induced neurotoxicity via promoting endoplasmic reticulum stress-associated apoptosis |
| title_sort | cordycepin exacerbates cadmium induced neurotoxicity via promoting endoplasmic reticulum stress associated apoptosis |
| topic | Cadmium Cordycepin Endoplasmic reticulum stress Apoptosis Neurotoxicity Food safety |
| url | http://www.sciencedirect.com/science/article/pii/S1756464622000056 |
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