Feasibility and usability of remote monitoring in Alzheimer's disease
Introduction Remote monitoring technologies (RMTs) can measure cognitive and functional decline objectively at-home, and offer opportunities to measure passively and continuously, possibly improving sensitivity and reducing participant burden in clinical trials. However, there is skepticism that age...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2024-04-01
|
| Series: | Digital Health |
| Online Access: | https://doi.org/10.1177/20552076241238133 |
| _version_ | 1797215569939791872 |
|---|---|
| author | Marijn Muurling Casper de Boer Chris Hinds Alankar Atreya Aiden Doherty Vasilis Alepopoulos Jelena Curcic Anna-Katharine Brem Pauline Conde Sajini Kuruppu Xavier Morató Valentina Saletti Samantha Galluzzi Estefania Vilarino Luis Sandra Cardoso Tina Stukelj Milica Gregorič Kramberger Dora Roik Ivan Koychev Ann-Cecilie Hopøy Emilia Schwertner Mara Gkioka Dag Aarsland Pieter Jelle Visser |
| author_facet | Marijn Muurling Casper de Boer Chris Hinds Alankar Atreya Aiden Doherty Vasilis Alepopoulos Jelena Curcic Anna-Katharine Brem Pauline Conde Sajini Kuruppu Xavier Morató Valentina Saletti Samantha Galluzzi Estefania Vilarino Luis Sandra Cardoso Tina Stukelj Milica Gregorič Kramberger Dora Roik Ivan Koychev Ann-Cecilie Hopøy Emilia Schwertner Mara Gkioka Dag Aarsland Pieter Jelle Visser |
| author_sort | Marijn Muurling |
| collection | DOAJ |
| description | Introduction Remote monitoring technologies (RMTs) can measure cognitive and functional decline objectively at-home, and offer opportunities to measure passively and continuously, possibly improving sensitivity and reducing participant burden in clinical trials. However, there is skepticism that age and cognitive or functional impairment may render participants unable or unwilling to comply with complex RMT protocols. We therefore assessed the feasibility and usability of a complex RMT protocol in all syndromic stages of Alzheimer's disease and in healthy control participants. Methods For 8 weeks, participants (N = 229) used two activity trackers, two interactive apps with either daily or weekly cognitive tasks, and optionally a wearable camera. A subset of participants participated in a 4-week sub-study (N = 45) using fixed at-home sensors, a wearable EEG sleep headband and a driving performance device. Feasibility was assessed by evaluating compliance and drop-out rates. Usability was assessed by problem rates (e.g., understanding instructions, discomfort, forgetting to use the RMT or technical problems) as discussed during bi-weekly semi-structured interviews. Results Most problems were found for the active apps and EEG sleep headband. Problem rates increased and compliance rates decreased with disease severity, but the study remained feasible. Conclusions This study shows that a highly complex RMT protocol is feasible, even in a mild-to-moderate AD population, encouraging other researchers to use RMTs in their study designs. We recommend evaluating the design of individual devices carefully before finalizing study protocols, considering RMTs which allow for real-time compliance monitoring, and engaging the partners of study participants in the research. |
| first_indexed | 2024-04-24T11:32:10Z |
| format | Article |
| id | doaj.art-8f9d109ddcd94a5bb7f99894759bc08c |
| institution | Directory Open Access Journal |
| issn | 2055-2076 |
| language | English |
| last_indexed | 2024-04-24T11:32:10Z |
| publishDate | 2024-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Digital Health |
| spelling | doaj.art-8f9d109ddcd94a5bb7f99894759bc08c2024-04-10T09:04:18ZengSAGE PublishingDigital Health2055-20762024-04-011010.1177/20552076241238133Feasibility and usability of remote monitoring in Alzheimer's diseaseMarijn Muurling0Casper de Boer1Chris Hinds2Alankar Atreya3Aiden Doherty4Vasilis Alepopoulos5Jelena Curcic6Anna-Katharine Brem7Pauline Conde8Sajini Kuruppu9Xavier Morató10Valentina Saletti11Samantha Galluzzi12Estefania Vilarino Luis13Sandra Cardoso14Tina Stukelj15Milica Gregorič Kramberger16Dora Roik17Ivan Koychev18Ann-Cecilie Hopøy19Emilia Schwertner20Mara Gkioka21Dag Aarsland22Pieter Jelle Visser23 24 , Neurodegeneration, Amsterdam, The Netherlands , Neurodegeneration, Amsterdam, The Netherlands Nuffield Department of Population Health, , Oxford, UK Nuffield Department of Population Health, , Oxford, UK Nuffield Department of Population Health, , Oxford, UK Information Technologies Institute, (CERTH-ITI), Thessaloniki, Greece , Switzerland Department of Old Age Psychiatry, University Hospital of Old Age Psychiatry, , Bern, Switzerland , London, UK , London, UK Ace Alzheimer Center Barcelona, , Barcelona, Spain Laboratory Alzheimer's Neuroimaging & Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy Laboratory Alzheimer's Neuroimaging & Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy Centre de la mémoire, Université de Genève (UNIGE), , Geneva, Switzerland Faculdade de Medicina da, , Lisbon, Portugal Department of Neurology, , University of Ljubljana, Ljubljana, Slovenia Division of Clinical Geriatrics, Department of Neurobiology, Department of Care Sciences and Society, , Stockholm, Sweden Department of Geriatric Psychiatry, Central Institute for Mental Health, , Heidelberg, Germany Department of Psychiatry, , Oxford, UK Department of Old Age Psychiatry, Centre for Age-Related Medicine, , Stavanger, Norway Faculty of Psychology, , Krakow, Poland Laboratory of Neurodegenerative Diseases, Center for Interdisciplinary Research and Innovation (CIRI – AUTh), Balkan Center, , Thessaloniki, Greece Department of Old Age Psychiatry, Centre for Age-Related Medicine, , Stavanger, Norway Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, , Maastricht, The Netherlands Introduction Remote monitoring technologies (RMTs) can measure cognitive and functional decline objectively at-home, and offer opportunities to measure passively and continuously, possibly improving sensitivity and reducing participant burden in clinical trials. However, there is skepticism that age and cognitive or functional impairment may render participants unable or unwilling to comply with complex RMT protocols. We therefore assessed the feasibility and usability of a complex RMT protocol in all syndromic stages of Alzheimer's disease and in healthy control participants. Methods For 8 weeks, participants (N = 229) used two activity trackers, two interactive apps with either daily or weekly cognitive tasks, and optionally a wearable camera. A subset of participants participated in a 4-week sub-study (N = 45) using fixed at-home sensors, a wearable EEG sleep headband and a driving performance device. Feasibility was assessed by evaluating compliance and drop-out rates. Usability was assessed by problem rates (e.g., understanding instructions, discomfort, forgetting to use the RMT or technical problems) as discussed during bi-weekly semi-structured interviews. Results Most problems were found for the active apps and EEG sleep headband. Problem rates increased and compliance rates decreased with disease severity, but the study remained feasible. Conclusions This study shows that a highly complex RMT protocol is feasible, even in a mild-to-moderate AD population, encouraging other researchers to use RMTs in their study designs. We recommend evaluating the design of individual devices carefully before finalizing study protocols, considering RMTs which allow for real-time compliance monitoring, and engaging the partners of study participants in the research.https://doi.org/10.1177/20552076241238133 |
| spellingShingle | Marijn Muurling Casper de Boer Chris Hinds Alankar Atreya Aiden Doherty Vasilis Alepopoulos Jelena Curcic Anna-Katharine Brem Pauline Conde Sajini Kuruppu Xavier Morató Valentina Saletti Samantha Galluzzi Estefania Vilarino Luis Sandra Cardoso Tina Stukelj Milica Gregorič Kramberger Dora Roik Ivan Koychev Ann-Cecilie Hopøy Emilia Schwertner Mara Gkioka Dag Aarsland Pieter Jelle Visser Feasibility and usability of remote monitoring in Alzheimer's disease Digital Health |
| title | Feasibility and usability of remote monitoring
in Alzheimer's disease |
| title_full | Feasibility and usability of remote monitoring
in Alzheimer's disease |
| title_fullStr | Feasibility and usability of remote monitoring
in Alzheimer's disease |
| title_full_unstemmed | Feasibility and usability of remote monitoring
in Alzheimer's disease |
| title_short | Feasibility and usability of remote monitoring
in Alzheimer's disease |
| title_sort | feasibility and usability of remote monitoring in alzheimer s disease |
| url | https://doi.org/10.1177/20552076241238133 |
| work_keys_str_mv | AT marijnmuurling feasibilityandusabilityofremotemonitoringinalzheimersdisease AT casperdeboer feasibilityandusabilityofremotemonitoringinalzheimersdisease AT chrishinds feasibilityandusabilityofremotemonitoringinalzheimersdisease AT alankaratreya feasibilityandusabilityofremotemonitoringinalzheimersdisease AT aidendoherty feasibilityandusabilityofremotemonitoringinalzheimersdisease AT vasilisalepopoulos feasibilityandusabilityofremotemonitoringinalzheimersdisease AT jelenacurcic feasibilityandusabilityofremotemonitoringinalzheimersdisease AT annakatharinebrem feasibilityandusabilityofremotemonitoringinalzheimersdisease AT paulineconde feasibilityandusabilityofremotemonitoringinalzheimersdisease AT sajinikuruppu feasibilityandusabilityofremotemonitoringinalzheimersdisease AT xaviermorato feasibilityandusabilityofremotemonitoringinalzheimersdisease AT valentinasaletti feasibilityandusabilityofremotemonitoringinalzheimersdisease AT samanthagalluzzi feasibilityandusabilityofremotemonitoringinalzheimersdisease AT estefaniavilarinoluis feasibilityandusabilityofremotemonitoringinalzheimersdisease AT sandracardoso feasibilityandusabilityofremotemonitoringinalzheimersdisease AT tinastukelj feasibilityandusabilityofremotemonitoringinalzheimersdisease AT milicagregorickramberger feasibilityandusabilityofremotemonitoringinalzheimersdisease AT doraroik feasibilityandusabilityofremotemonitoringinalzheimersdisease AT ivankoychev feasibilityandusabilityofremotemonitoringinalzheimersdisease AT annceciliehopøy feasibilityandusabilityofremotemonitoringinalzheimersdisease AT emiliaschwertner feasibilityandusabilityofremotemonitoringinalzheimersdisease AT maragkioka feasibilityandusabilityofremotemonitoringinalzheimersdisease AT dagaarsland feasibilityandusabilityofremotemonitoringinalzheimersdisease AT pieterjellevisser feasibilityandusabilityofremotemonitoringinalzheimersdisease AT feasibilityandusabilityofremotemonitoringinalzheimersdisease |