Protein Levels of Anti-Apoptotic Mcl-1 and the Deubiquitinase USP9x Are Cooperatively Upregulated during Prostate Cancer Progression and Limit Response of Prostate Cancer Cells to Radiotherapy

Protein Levels of Anti-Apoptotic Mcl-1 and the Deubiquitinase USP9x Are Cooperatively Upregulated during Prostate Cancer Progression and Limit Response of Prostate Cancer Cells to Radiotherapy

Background: Radiotherapy constitutes an important therapeutic option for prostate cancer. However, prostate cancer cells often acquire resistance during cancer progression, limiting the cytotoxic effects of radiotherapy. Among factors regulating sensitivity to radiotherapy are members of the Bcl-2 p...

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Bibliographic Details
Main Authors: Sophia A. Hogh-Binder, Diana Klein, Frederik Wolfsperger, Stephan M. Huber, Jörg Hennenlotter, Arnulf Stenzl, Justine Rudner
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Cancers
Subjects:
prostate cancer
radiotherapy
Mcl-1
protein stability
ubiquitylation
USP9x
Online Access:https://www.mdpi.com/2072-6694/15/9/2496

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