The role of admixture in the rare variant contribution to inflammatory bowel disease

The role of admixture in the rare variant contribution to inflammatory bowel disease

Abstract Background Identification of rare variants involved in complex, polygenic diseases like Crohn’s disease (CD) has accelerated with the introduction of whole exome/genome sequencing association studies. Rare variants can be used in both diagnostic and therapeutic assessments; however, since t...

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Bibliographic Details
Main Authors: Courtney Astore, Shivam Sharma, Sini Nagpal, NIDDK IBD Genetics Consortium, David J. Cutler, John D. Rioux, Judy H. Cho, Dermot P. B. McGovern, Steven R. Brant, Subra Kugathasan, I. King Jordan, Greg Gibson
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Genome Medicine
Subjects:
Trans-ancestry
Crohn’s disease
NOD2
Genetic risk assessment
Whole genome sequencing
Online Access:https://doi.org/10.1186/s13073-023-01244-w

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