A Novel AURKA Mutant-Induced Early-Onset Severe Hepatocarcinogenesis Greater than Wild-Type via Activating Different Pathways in Zebrafish

A Novel AURKA Mutant-Induced Early-Onset Severe Hepatocarcinogenesis Greater than Wild-Type via Activating Different Pathways in Zebrafish

Aurora A kinase (AURKA) is an important regulator in mitotic progression and is overexpressed frequently in human cancers, including hepatocellular carcinoma (HCC). Many AURKA mutations were identified in cancer patients. Overexpressing wild-type Aurka developed a low incidence of hepatic tumors aft...

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Bibliographic Details
Main Authors: Zhong-Liang Su, Chien-Wei Su, Yi-Luen Huang, Wan-Yu Yang, Bonifasius Putera Sampurna, Toru Ouchi, Kuan-Lin Lee, Chen-Sheng Wu, Horng-Dar Wang, Chiou-Hwa Yuh
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Cancers
Subjects:
hepatocellular carcinoma (HCC)
zebrafish
Aurora A kinase (AURKA)
β-catenin
AKT signaling pathway
Online Access:https://www.mdpi.com/2072-6694/11/7/927

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