Identification of ZIC2 as a Potential Biomarker Linked with the Clinical Progression and Immune Infiltration of Oral Cancer: A Multicenter Study
Aim. To investigate the specific expression profile, clinicopathological significance and mechanism of Zic family member 2 (ZIC2) in oral cancer were unclear. Patients and Methods. We explored the expression pattern and clinicopathological significance of ZIC2 in oral cancer through performing in-ho...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2024-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2024/3256694 |
| _version_ | 1827077580229967872 |
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| author | Li Gao Shi-Bai Yan Fang-Cheng Jiang Zhi-Guang Huang Dong-Ming Li Yu-Lu Tang Jia-Yuan Luo Gang Chen Dan-Ming Wei |
| author_facet | Li Gao Shi-Bai Yan Fang-Cheng Jiang Zhi-Guang Huang Dong-Ming Li Yu-Lu Tang Jia-Yuan Luo Gang Chen Dan-Ming Wei |
| author_sort | Li Gao |
| collection | DOAJ |
| description | Aim. To investigate the specific expression profile, clinicopathological significance and mechanism of Zic family member 2 (ZIC2) in oral cancer were unclear. Patients and Methods. We explored the expression pattern and clinicopathological significance of ZIC2 in oral cancer through performing in-house tissue microarray and integrated analysis global RNA-seq and microarrays containing large samples. The molecular basis of ZIC2 in oral cancer was further investigated in the aspects of transcription network and immune correlations. We also performed in vitro experiments and calculated drug sensitivity of oral cancer with different ZIC2 expression levels in response to hundreds of compounds. Results. All data unanimously proved the significant overexpression of ZIC2 in oral cancer. The upregulation of ZIC2 was remarkably associated with the malignant clinical progression of oral cancer. ZIC2 was predicted to be targeted by miRNAs such as miR-3140, miR-4999, and miR-1322. The infiltration level of CD8+ T and central memory cells was positively related to the overexpression of ZIC2. Oral cancer patients with higher ZIC2 expression showed higher drug sensitivity to two compounds including AZD8186 and ERK_2240. Conclusions. We demonstrated the upregulation of ZIC2 in oral cancer and its promoting effect on the clinical advancement of oral cancer. The potential clinical value of ZIC2 in oral cancer deserves attention. |
| first_indexed | 2024-03-08T09:09:28Z |
| format | Article |
| id | doaj.art-8f9f045b98354d7881bcbcf5db727d22 |
| institution | Directory Open Access Journal |
| issn | 2314-4378 |
| language | English |
| last_indexed | 2025-03-20T02:16:02Z |
| publishDate | 2024-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj.art-8f9f045b98354d7881bcbcf5db727d222024-10-03T07:51:14ZengHindawi LimitedInternational Journal of Genomics2314-43782024-01-01202410.1155/2024/3256694Identification of ZIC2 as a Potential Biomarker Linked with the Clinical Progression and Immune Infiltration of Oral Cancer: A Multicenter StudyLi Gao0Shi-Bai Yan1Fang-Cheng Jiang2Zhi-Guang Huang3Dong-Ming Li4Yu-Lu Tang5Jia-Yuan Luo6Gang Chen7Dan-Ming Wei8Department of PathologyDepartment of PathologyDepartment of PathologyDepartment of PathologyDepartment of PathologyDepartment of PathologyDepartment of PathologyDepartment of PathologyDepartment of PathologyAim. To investigate the specific expression profile, clinicopathological significance and mechanism of Zic family member 2 (ZIC2) in oral cancer were unclear. Patients and Methods. We explored the expression pattern and clinicopathological significance of ZIC2 in oral cancer through performing in-house tissue microarray and integrated analysis global RNA-seq and microarrays containing large samples. The molecular basis of ZIC2 in oral cancer was further investigated in the aspects of transcription network and immune correlations. We also performed in vitro experiments and calculated drug sensitivity of oral cancer with different ZIC2 expression levels in response to hundreds of compounds. Results. All data unanimously proved the significant overexpression of ZIC2 in oral cancer. The upregulation of ZIC2 was remarkably associated with the malignant clinical progression of oral cancer. ZIC2 was predicted to be targeted by miRNAs such as miR-3140, miR-4999, and miR-1322. The infiltration level of CD8+ T and central memory cells was positively related to the overexpression of ZIC2. Oral cancer patients with higher ZIC2 expression showed higher drug sensitivity to two compounds including AZD8186 and ERK_2240. Conclusions. We demonstrated the upregulation of ZIC2 in oral cancer and its promoting effect on the clinical advancement of oral cancer. The potential clinical value of ZIC2 in oral cancer deserves attention.http://dx.doi.org/10.1155/2024/3256694 |
| spellingShingle | Li Gao Shi-Bai Yan Fang-Cheng Jiang Zhi-Guang Huang Dong-Ming Li Yu-Lu Tang Jia-Yuan Luo Gang Chen Dan-Ming Wei Identification of ZIC2 as a Potential Biomarker Linked with the Clinical Progression and Immune Infiltration of Oral Cancer: A Multicenter Study International Journal of Genomics |
| title | Identification of ZIC2 as a Potential Biomarker Linked with the Clinical Progression and Immune Infiltration of Oral Cancer: A Multicenter Study |
| title_full | Identification of ZIC2 as a Potential Biomarker Linked with the Clinical Progression and Immune Infiltration of Oral Cancer: A Multicenter Study |
| title_fullStr | Identification of ZIC2 as a Potential Biomarker Linked with the Clinical Progression and Immune Infiltration of Oral Cancer: A Multicenter Study |
| title_full_unstemmed | Identification of ZIC2 as a Potential Biomarker Linked with the Clinical Progression and Immune Infiltration of Oral Cancer: A Multicenter Study |
| title_short | Identification of ZIC2 as a Potential Biomarker Linked with the Clinical Progression and Immune Infiltration of Oral Cancer: A Multicenter Study |
| title_sort | identification of zic2 as a potential biomarker linked with the clinical progression and immune infiltration of oral cancer a multicenter study |
| url | http://dx.doi.org/10.1155/2024/3256694 |
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