TP53 Mutations in Acute Myeloid Leukemia: Still a Daunting Challenge?

TP53 Mutations in Acute Myeloid Leukemia: Still a Daunting Challenge?

TP53 is a key tumor suppressor gene with protean functions associated with preservation of genomic balance, including regulation of cellular senescence, apoptotic pathways, metabolism functions, and DNA repair. The vast majority of de novo acute myeloid leukemia (AML) present unaltered TP53 alleles....

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Bibliographic Details
Main Authors: Matteo Molica, Carla Mazzone, Pasquale Niscola, Paolo de Fabritiis
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Oncology
Subjects:
acute myeloid leukemia
TP53 mutations
poor outcome
decitabine
venetoclax (BCL-2 inhibitor)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.610820/full

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