Influenza vaccine effectiveness against hospitalizations in children and older adults—Data from South America, 2013–2017. A test negative design
Background: In 2013, the Pan American Health Organization established a multi-site, multi-country network to evaluate influenza vaccine effectiveness (VE). We pooled data from five consecutive seasons in five countries to conduct an analysis of southern hemisphere VE against laboratory-confirmed inf...
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-12-01
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| Series: | Vaccine: X |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590136219300488 |
| _version_ | 1818120209164140544 |
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| author | Carmen Sofia Arriola Nathalie El Omeiri Eduardo Azziz-Baumgartner Mark G. Thompson Viviana Sotomayor-Proschle Rodrigo A. Fasce Martha Von Horoch José Enrique Carrizo Olalla Walquíria Aparecida Ferreira de Almeida Jacqueline Palacios Rakhee Palekar Paula Couto Miguel Descalzo Alba María Ropero-Álvarez Cecilia Gonzalez Sergio Loayza Natalia Vergara Patricia Bustos Winston Andrade Carla Magda S. Domingues Ernesto Issac Montenegro Renoiner Érica Tatiane da Silva Swamy Lima Palmeira Daiana Araujo da Silva Ana Carolina de Lacerda Sousa Marilda Mendonça Siqueira Cynthia Vazquez Silvia Battaglia Carla Vizzotti Elsa Baumeister Carlos Giovacchini Nathalia Katz Oscar Pacheco Juliana Barbosa Diana Malo Paola Pulido Diego Garcia Consuelo Pinzón |
| author_facet | Carmen Sofia Arriola Nathalie El Omeiri Eduardo Azziz-Baumgartner Mark G. Thompson Viviana Sotomayor-Proschle Rodrigo A. Fasce Martha Von Horoch José Enrique Carrizo Olalla Walquíria Aparecida Ferreira de Almeida Jacqueline Palacios Rakhee Palekar Paula Couto Miguel Descalzo Alba María Ropero-Álvarez Cecilia Gonzalez Sergio Loayza Natalia Vergara Patricia Bustos Winston Andrade Carla Magda S. Domingues Ernesto Issac Montenegro Renoiner Érica Tatiane da Silva Swamy Lima Palmeira Daiana Araujo da Silva Ana Carolina de Lacerda Sousa Marilda Mendonça Siqueira Cynthia Vazquez Silvia Battaglia Carla Vizzotti Elsa Baumeister Carlos Giovacchini Nathalia Katz Oscar Pacheco Juliana Barbosa Diana Malo Paola Pulido Diego Garcia Consuelo Pinzón |
| author_sort | Carmen Sofia Arriola |
| collection | DOAJ |
| description | Background: In 2013, the Pan American Health Organization established a multi-site, multi-country network to evaluate influenza vaccine effectiveness (VE). We pooled data from five consecutive seasons in five countries to conduct an analysis of southern hemisphere VE against laboratory-confirmed influenza hospitalizations in young children and older adults. Methods: We used a test-negative design to estimate VE against laboratory-confirmed influenza in hospitalized young children (aged 6─24 months) and older adults (aged ≥60 years) in Argentina, Brazil, Chile, Colombia, and Paraguay. Following country-specific influenza surveillance protocol, hospitalized persons with severe acute respiratory infections (SARI) at 48 sentinel hospitals (March 2013–December 2017) were tested for influenza virus infection by rRT-PCR. VE was estimated for young children and older adults using logistic random effects models accounting for cluster (country), adjusting for sex, age (months for children, and age-in-year categories for adults), calendar year, country, preexisting conditions, month of illness onset and prior vaccination as an effect modifier for the analysis in adults. Results: We included 8426 SARI cases (2389 children and 6037 adults) in the VE analyses. Among young children, VE against SARI hospitalization associated with any influenza virus was 43% (95%CI: 33%, 51%) for children who received two doses, but was 20% (95%CI: −16%, 45%) and not statistically significant for those who received one dose in a given season. Among older adults, overall VE against SARI hospitalization associated with any influenza virus was 41% (95%CI: 28%, 52%), 45% (95%CI: 34%, 53%) against A(H3N2), 40% (95%CI: 18%, 56%) against A(H1N1)pdm09, and 20% (95%CI: −40%, 54%) against influenza B viruses. Conclusions: Our results suggest that over the five-year study period, influenza vaccination programs in five South American countries prevented more than one-third of laboratory confirmed influenza-associated hospitalizations in young children receiving the recommended two doses and vaccinated older adults. Keywords: Influenza vaccine effectiveness, Children, Adults, Southern hemisphere, Latin America, Severe acute respiratory infections, Test-negative case-control design, Hospitalizations |
| first_indexed | 2024-12-11T05:22:27Z |
| format | Article |
| id | doaj.art-8fa4a2959e6f41d5bf455d1b944f534c |
| institution | Directory Open Access Journal |
| issn | 2590-1362 |
| language | English |
| last_indexed | 2024-12-11T05:22:27Z |
| publishDate | 2019-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Vaccine: X |
| spelling | doaj.art-8fa4a2959e6f41d5bf455d1b944f534c2022-12-22T01:19:40ZengElsevierVaccine: X2590-13622019-12-013Influenza vaccine effectiveness against hospitalizations in children and older adults—Data from South America, 2013–2017. A test negative designCarmen Sofia Arriola0Nathalie El Omeiri1Eduardo Azziz-Baumgartner2Mark G. Thompson3Viviana Sotomayor-Proschle4Rodrigo A. Fasce5Martha Von Horoch6José Enrique Carrizo Olalla7Walquíria Aparecida Ferreira de Almeida8Jacqueline Palacios9Rakhee Palekar10Paula Couto11Miguel Descalzo12Alba María Ropero-Álvarez13Cecilia Gonzalez14Sergio Loayza15Natalia Vergara16Patricia Bustos17Winston Andrade18Carla Magda S. Domingues19Ernesto Issac Montenegro Renoiner20Érica Tatiane da Silva21Swamy Lima Palmeira22Daiana Araujo da Silva23Ana Carolina de Lacerda Sousa24Marilda Mendonça Siqueira25Cynthia Vazquez26Silvia Battaglia27Carla Vizzotti28Elsa Baumeister29Carlos Giovacchini30Nathalia Katz31Oscar Pacheco32Juliana Barbosa33Diana Malo34Paola Pulido35Diego Garcia36Consuelo Pinzón37Influenza Division, US Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA; Corresponding authors at: Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd MS A-32, Atlanta, GA 30333, USA (C. Sofia Arriola). Pan American Health Organization, 525 Twenty Third St., NW, Washington, DC 20037-2895, USA (N. El Omeiri).Department of Family Gender and Life Course/Immunization, Pan American Health Organization/World Health Organization (PAHO/WHO), Washington, DC, USA; Corresponding authors at: Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd MS A-32, Atlanta, GA 30333, USA (C. Sofia Arriola). Pan American Health Organization, 525 Twenty Third St., NW, Washington, DC 20037-2895, USA (N. El Omeiri).Influenza Division, US Centers for Disease Control and Prevention (CDC), Atlanta, GA, USAInfluenza Division, US Centers for Disease Control and Prevention (CDC), Atlanta, GA, USAEpidemiology Department, Ministry of Health, ChilePublic Health Institute, Ministry of Health, ChileHealth Surveillance Unit, Ministry of Public Health and Social Welfare, ParaguayEpidemiology Department, Ministry of Health, ArgentinaDepartment of Communicable Diseases Surveillance, Ministry of Health, BrazilMinistry of Health, ColombiaDepartment of Public Health Emergencies, PAHO/WHO, Washington, DC, USADepartment of Public Health Emergencies, PAHO/WHO, Washington, DC, USAPAHO/WHO International Consultant, USADepartment of Family Gender and Life Course/Immunization, Pan American Health Organization/World Health Organization (PAHO/WHO), Washington, DC, USAMinistry of Health, ChileMinistry of Health, ChileMinistry of Health, ChilePublic Health Institute, ChilePublic Health Institute, ChileMinistry of Health, BrazilMinistry of Health, BrazilMinistry of Health, BrazilMinistry of Health, BrazilMinistry of Health, BrazilMinistry of Health, BrazilFundação Oswaldo Cruz, BrazilMinistry of Health, ParaguayMinistry of Health, ParaguayMinistry of Health, ArgentinaMinistry of Health, ArgentinaMinistry of Health, ArgentinaMinistry of Health, ArgentinaNational Health Institute, ColombiaNational Health Institute, ColombiaNational Health Institute, ColombiaNational Health Institute, ColombiaMinistry of Health, ColombiaMinistry of Health, ColombiaBackground: In 2013, the Pan American Health Organization established a multi-site, multi-country network to evaluate influenza vaccine effectiveness (VE). We pooled data from five consecutive seasons in five countries to conduct an analysis of southern hemisphere VE against laboratory-confirmed influenza hospitalizations in young children and older adults. Methods: We used a test-negative design to estimate VE against laboratory-confirmed influenza in hospitalized young children (aged 6─24 months) and older adults (aged ≥60 years) in Argentina, Brazil, Chile, Colombia, and Paraguay. Following country-specific influenza surveillance protocol, hospitalized persons with severe acute respiratory infections (SARI) at 48 sentinel hospitals (March 2013–December 2017) were tested for influenza virus infection by rRT-PCR. VE was estimated for young children and older adults using logistic random effects models accounting for cluster (country), adjusting for sex, age (months for children, and age-in-year categories for adults), calendar year, country, preexisting conditions, month of illness onset and prior vaccination as an effect modifier for the analysis in adults. Results: We included 8426 SARI cases (2389 children and 6037 adults) in the VE analyses. Among young children, VE against SARI hospitalization associated with any influenza virus was 43% (95%CI: 33%, 51%) for children who received two doses, but was 20% (95%CI: −16%, 45%) and not statistically significant for those who received one dose in a given season. Among older adults, overall VE against SARI hospitalization associated with any influenza virus was 41% (95%CI: 28%, 52%), 45% (95%CI: 34%, 53%) against A(H3N2), 40% (95%CI: 18%, 56%) against A(H1N1)pdm09, and 20% (95%CI: −40%, 54%) against influenza B viruses. Conclusions: Our results suggest that over the five-year study period, influenza vaccination programs in five South American countries prevented more than one-third of laboratory confirmed influenza-associated hospitalizations in young children receiving the recommended two doses and vaccinated older adults. Keywords: Influenza vaccine effectiveness, Children, Adults, Southern hemisphere, Latin America, Severe acute respiratory infections, Test-negative case-control design, Hospitalizationshttp://www.sciencedirect.com/science/article/pii/S2590136219300488 |
| spellingShingle | Carmen Sofia Arriola Nathalie El Omeiri Eduardo Azziz-Baumgartner Mark G. Thompson Viviana Sotomayor-Proschle Rodrigo A. Fasce Martha Von Horoch José Enrique Carrizo Olalla Walquíria Aparecida Ferreira de Almeida Jacqueline Palacios Rakhee Palekar Paula Couto Miguel Descalzo Alba María Ropero-Álvarez Cecilia Gonzalez Sergio Loayza Natalia Vergara Patricia Bustos Winston Andrade Carla Magda S. Domingues Ernesto Issac Montenegro Renoiner Érica Tatiane da Silva Swamy Lima Palmeira Daiana Araujo da Silva Ana Carolina de Lacerda Sousa Marilda Mendonça Siqueira Cynthia Vazquez Silvia Battaglia Carla Vizzotti Elsa Baumeister Carlos Giovacchini Nathalia Katz Oscar Pacheco Juliana Barbosa Diana Malo Paola Pulido Diego Garcia Consuelo Pinzón Influenza vaccine effectiveness against hospitalizations in children and older adults—Data from South America, 2013–2017. A test negative design Vaccine: X |
| title | Influenza vaccine effectiveness against hospitalizations in children and older adults—Data from South America, 2013–2017. A test negative design |
| title_full | Influenza vaccine effectiveness against hospitalizations in children and older adults—Data from South America, 2013–2017. A test negative design |
| title_fullStr | Influenza vaccine effectiveness against hospitalizations in children and older adults—Data from South America, 2013–2017. A test negative design |
| title_full_unstemmed | Influenza vaccine effectiveness against hospitalizations in children and older adults—Data from South America, 2013–2017. A test negative design |
| title_short | Influenza vaccine effectiveness against hospitalizations in children and older adults—Data from South America, 2013–2017. A test negative design |
| title_sort | influenza vaccine effectiveness against hospitalizations in children and older adults data from south america 2013 2017 a test negative design |
| url | http://www.sciencedirect.com/science/article/pii/S2590136219300488 |
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