| Summary: | <i>Convolvulus arvensis</i> is a medicinal plant in the family Convolvulaceae, which is used in traditional phytotherapy. The objective of this work was conducted to valorize essential oils of <i>Convolvulus arvensis</i> (EOCA) in terms of chemical composition, antioxidant, and antibacterial properties. To achieve this objective, the chemical composition was performed by the use of GC-SM. Antioxidant power was effectuated by the use of DPPH, FRAP, and TAC assays. Evaluation of the antimicrobial power was conducted against clinically important pathogenic bacteria (<i>E. coli, K. pneumoniae, S. pneumoniae,</i> and <i>S. aureus</i>) and fungi (<i>A. niger, C. albicans,</i> and <i>A. flavus</i>) by the use of disc diffusion and minimum inhibitory concentrations (MICs) assays. The results showed that the yield of recovered EOs from <i>Convolvulus arvensis</i> was 0.34% of the total mass of leaves and mainly was rich in cuprenne (34%), thymol (20%), himachalene (16%), and longifolene (10%). Notably, EOCA exhibited important antioxidant effects, wherein IC<sub>50</sub> (DPPH) and EC<sub>50</sub> (FRAP) were determined to be 30 µg/mL and 120 µg/mL, respectively, while the total antioxidant power was determined to be 508.0 ± 6.0 µg EAA/mg. An important antibacterial effect was noted for EOCA as an excellent inhibition zone was recorded against all bacterial strains, particularly <i>K. pneumoniae</i> and <i>S. aureus</i> with 14.27 ± 0.42 and 21.35 ± 0.76 mm, respectively. Similarly, MICs of <i>K. pneumoniae</i> and <i>S. aureus</i> were 21.35 ± 0.76 mm and 28.62 ± 1.65 µg/mL, respectively. Noticeably, important antifungal activity was shown by EOCA against all fungal strains wherein the inhibition zone diameters against all fungal species ranged from 19.44 ± 1.10 to 20.41 ± 1.81 mm. Notably, MICs of EOCA against <i>F. oxysporum</i> and <i>C. albicans</i> were 18.65 ± 0.94 and 19.38 ± 0.58 g/mL, respectively. The outcome of the present work showed that EOs from <i>Convolvulus arvensis</i> can be used to conceptualize drugs to manage diseases relative to free radicals and infections.
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