SARA suppresses myofibroblast precursor transdifferentiation in fibrogenesis in a mouse model of scleroderma

SARA suppresses myofibroblast precursor transdifferentiation in fibrogenesis in a mouse model of scleroderma

We previously reported that Smad anchor for receptor activation (SARA) plays a critical role in maintaining epithelial cell phenotype. Here, we show that SARA suppressed myofibroblast precursor transdifferentiation in a mouse model of scleroderma. Mice overexpressing SARA specifically in PDGFR-β+ pe...

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Bibliographic Details
Main Authors:	Katia Corano Scheri, Xiaoyan Liang, Vidhi Dalal, I. Caroline Le Poole, John Varga, Tomoko Hayashida
Format:	Article
Language:	English
Published:	American Society for Clinical investigation 2022-11-01
Series:	JCI Insight
Subjects:	Cell biology
Online Access:	https://doi.org/10.1172/jci.insight.160977

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