Serum 25 Hydroxyvitamin D Levels During Pregnancy in Women with Asthma: Associations with Maternal Characteristics and Adverse Maternal and Neonatal Outcomes
Low 25-hydroxyvitamin D (25(OH)D) levels are common in pregnancy and associated with adverse maternal/neonatal outcomes. In pregnant women with asthma, this study examined the association of lifestyle- and asthma-related factors on 25(OH)D levels and maternal/neonatal outcomes by vitamin D status. S...
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MDPI AG
2020-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/10/2978 |
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| author | Megan E. Jensen Carlos A. Camargo Soriah M. Harvey Peter G. Gibson Vanessa E. Murphy |
| author_facet | Megan E. Jensen Carlos A. Camargo Soriah M. Harvey Peter G. Gibson Vanessa E. Murphy |
| author_sort | Megan E. Jensen |
| collection | DOAJ |
| description | Low 25-hydroxyvitamin D (25(OH)D) levels are common in pregnancy and associated with adverse maternal/neonatal outcomes. In pregnant women with asthma, this study examined the association of lifestyle- and asthma-related factors on 25(OH)D levels and maternal/neonatal outcomes by vitamin D status. Serum 25(OH)D was measured at 16 and 35 weeks gestation in women with asthma (<i>n</i> = 103). Body mass index (BMI), gestational weight gain (GWG), smoking status, inhaled corticosteroid (ICS) use, asthma control, airway inflammation, and exacerbations, and maternal/neonatal outcomes were collected. Baseline and change (Δ) in 25(OH)D were modelled separately using backward stepwise regression, adjusted for season and ethnicity. Maternal/neonatal outcomes were compared between low (25(OH)D < 75 nmol/L at both time points) and high (≥75 nmol/L at one or both time points) vitamin D status. Fifty-six percent of women had low vitamin D status. Obesity was significantly associated with lower baseline 25(OH)D (Adj-R<sup>2</sup> = 0.126, <i>p</i> = 0.008); ICS and airway inflammation were not. Excess GWG and season of baseline sample collection were significantly associated with Δ25(OH)D (Adj-R<sup>2</sup> = 0.405, <i>p</i> < 0.0001); asthma-related variables were excluded (<i>p</i> > 0.2). Preeclampsia was more common in the low (8.6%) vs. high (0%) vitamin D group (<i>p</i> < 0.05). Obesity and excess GWG may be associated with gestational 25(OH)D levels, highlighting the importance of antenatal weight management. |
| first_indexed | 2024-03-10T15:57:58Z |
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| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T15:57:58Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-8fa95875a0ac441f86d555ab17128f452023-11-20T15:29:30ZengMDPI AGNutrients2072-66432020-09-011210297810.3390/nu12102978Serum 25 Hydroxyvitamin D Levels During Pregnancy in Women with Asthma: Associations with Maternal Characteristics and Adverse Maternal and Neonatal OutcomesMegan E. Jensen0Carlos A. Camargo1Soriah M. Harvey2Peter G. Gibson3Vanessa E. Murphy4Priority Research Centre Grow Up Well, Hunter Medical Research Institute and University of Newcastle, New Lambton Heights, NSW 2305, AustraliaDepartment of Emergency Medicine, Massachusetts General Hospital, Boston, MA 02114, USAPriority Research Centre Grow Up Well, Hunter Medical Research Institute and University of Newcastle, New Lambton Heights, NSW 2305, AustraliaPriority Research Centre for Healthy Lungs, Hunter Medical Research Institute and University of Newcastle, New Lambton Heights, NSW 2305, AustraliaPriority Research Centre Grow Up Well, Hunter Medical Research Institute and University of Newcastle, New Lambton Heights, NSW 2305, AustraliaLow 25-hydroxyvitamin D (25(OH)D) levels are common in pregnancy and associated with adverse maternal/neonatal outcomes. In pregnant women with asthma, this study examined the association of lifestyle- and asthma-related factors on 25(OH)D levels and maternal/neonatal outcomes by vitamin D status. Serum 25(OH)D was measured at 16 and 35 weeks gestation in women with asthma (<i>n</i> = 103). Body mass index (BMI), gestational weight gain (GWG), smoking status, inhaled corticosteroid (ICS) use, asthma control, airway inflammation, and exacerbations, and maternal/neonatal outcomes were collected. Baseline and change (Δ) in 25(OH)D were modelled separately using backward stepwise regression, adjusted for season and ethnicity. Maternal/neonatal outcomes were compared between low (25(OH)D < 75 nmol/L at both time points) and high (≥75 nmol/L at one or both time points) vitamin D status. Fifty-six percent of women had low vitamin D status. Obesity was significantly associated with lower baseline 25(OH)D (Adj-R<sup>2</sup> = 0.126, <i>p</i> = 0.008); ICS and airway inflammation were not. Excess GWG and season of baseline sample collection were significantly associated with Δ25(OH)D (Adj-R<sup>2</sup> = 0.405, <i>p</i> < 0.0001); asthma-related variables were excluded (<i>p</i> > 0.2). Preeclampsia was more common in the low (8.6%) vs. high (0%) vitamin D group (<i>p</i> < 0.05). Obesity and excess GWG may be associated with gestational 25(OH)D levels, highlighting the importance of antenatal weight management.https://www.mdpi.com/2072-6643/12/10/2978maternal nutrition physiologyvitamin Dpregnancyasthmamaternal obesitygestational weight gain |
| spellingShingle | Megan E. Jensen Carlos A. Camargo Soriah M. Harvey Peter G. Gibson Vanessa E. Murphy Serum 25 Hydroxyvitamin D Levels During Pregnancy in Women with Asthma: Associations with Maternal Characteristics and Adverse Maternal and Neonatal Outcomes Nutrients maternal nutrition physiology vitamin D pregnancy asthma maternal obesity gestational weight gain |
| title | Serum 25 Hydroxyvitamin D Levels During Pregnancy in Women with Asthma: Associations with Maternal Characteristics and Adverse Maternal and Neonatal Outcomes |
| title_full | Serum 25 Hydroxyvitamin D Levels During Pregnancy in Women with Asthma: Associations with Maternal Characteristics and Adverse Maternal and Neonatal Outcomes |
| title_fullStr | Serum 25 Hydroxyvitamin D Levels During Pregnancy in Women with Asthma: Associations with Maternal Characteristics and Adverse Maternal and Neonatal Outcomes |
| title_full_unstemmed | Serum 25 Hydroxyvitamin D Levels During Pregnancy in Women with Asthma: Associations with Maternal Characteristics and Adverse Maternal and Neonatal Outcomes |
| title_short | Serum 25 Hydroxyvitamin D Levels During Pregnancy in Women with Asthma: Associations with Maternal Characteristics and Adverse Maternal and Neonatal Outcomes |
| title_sort | serum 25 hydroxyvitamin d levels during pregnancy in women with asthma associations with maternal characteristics and adverse maternal and neonatal outcomes |
| topic | maternal nutrition physiology vitamin D pregnancy asthma maternal obesity gestational weight gain |
| url | https://www.mdpi.com/2072-6643/12/10/2978 |
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