A comprehensive review on clinically proven medicinal plants in the treatment of overweight and obesity, with mechanistic insights
Background and objectives: Obesity has become a global health issue, more precisely, a pandemic throughout the present world due to its high prevalence in the recent era. Increased risk of morbidity and mortality in obese patients can be attributed to its association with the development of differen...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-02-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023007004 |
| _version_ | 1811161741861584896 |
|---|---|
| author | Md Abdul Aziz Md Shalahuddin Millat Tahmina Akter Md Shahadat Hossain Md Monirul Islam Shahriar Mohsin Farzana Ansari Asma Kabir Mohammad Nurul Amin Mohammad Safiqul Islam |
| author_facet | Md Abdul Aziz Md Shalahuddin Millat Tahmina Akter Md Shahadat Hossain Md Monirul Islam Shahriar Mohsin Farzana Ansari Asma Kabir Mohammad Nurul Amin Mohammad Safiqul Islam |
| author_sort | Md Abdul Aziz |
| collection | DOAJ |
| description | Background and objectives: Obesity has become a global health issue, more precisely, a pandemic throughout the present world due to its high prevalence in the recent era. Increased risk of morbidity and mortality in obese patients can be attributed to its association with the development of different life-threatening conditions. Plants are considered one of the most important sources of bioactive molecules which are used against a wide range of health disorders. This systematic review explores the efficacy as well as the safety profile of commonly used medicinal plants in the management of obesity that may help people to maintain a healthy weight. Methods: This review is based on comprehensive literature searches from PubMed, Science Direct, Scopus, and Google Scholar databases using the keywords- “plants in obesity”, “plants used in weight reduction” or keywords that are similar to those. Medicinal plants which have been clinically proven for their anti-obesity effect have only been selected for this study and attempts to investigate beneficial effects and adverse effects along with their mechanism of action have also been taken in this review. Results: A significant reduction of weight in both human and other animals are exhibited by the extracts of Phaseolus vulgaris, green coffee, Yerba Mate, green tea, Gynostemma pentaphyllum, and the combination of Cissus quadrangularis/Irvingia gabonensis. All of those plant extracts seemed to work on different physiological pathways and none of those extracts showed any notable adverse effects in human or animal models. Conclusion: Our review suggests that the discussed medicinal plants are effective in reducing the weight of obese patients without causing notable adverse reactions. Although further study is necessary to confirm their exact molecular mechanism and safety in human use. |
| first_indexed | 2024-04-10T06:19:40Z |
| format | Article |
| id | doaj.art-8fac667e2b2345dbbaefe068ccae9846 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-10T06:19:40Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-8fac667e2b2345dbbaefe068ccae98462023-03-02T05:01:50ZengElsevierHeliyon2405-84402023-02-0192e13493A comprehensive review on clinically proven medicinal plants in the treatment of overweight and obesity, with mechanistic insightsMd Abdul Aziz0Md Shalahuddin Millat1Tahmina Akter2Md Shahadat Hossain3Md Monirul Islam4Shahriar Mohsin5Farzana Ansari6Asma Kabir7Mohammad Nurul Amin8Mohammad Safiqul Islam9Department of Pharmacy, State University of Bangladesh, Dhaka, 1205, BangladeshDepartment of Pharmacy, Noakhali Science and Technology University, Sonapur, 3814, BangladeshDepartment of Pharmacy, Noakhali Science and Technology University, Sonapur, 3814, BangladeshDepartment of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, 1230, BangladeshDepartment of Pharmacy, State University of Bangladesh, Dhaka, 1205, BangladeshCenter of Molecular Biotechnology, University of Bonn, 53115 Bonn, GermanyDepartment of Biochemistry and Molecular Biology, Laboratory of Nutrition and Health Research, University of Dhaka, Dhaka, 1000, BangladeshDepartment of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, 1230, BangladeshDepartment of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, 1230, Bangladesh; Pratyasha Health Biomedical Research Center, Dhaka, 1230, Bangladesh; Corresponding author. Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, 1230, Bangladesh.Department of Pharmacy, Noakhali Science and Technology University, Sonapur, 3814, Bangladesh; Corresponding author. Department of Pharmacy, Noakhali Science and Technology University, Sonapur, 3814, Bangladesh.Background and objectives: Obesity has become a global health issue, more precisely, a pandemic throughout the present world due to its high prevalence in the recent era. Increased risk of morbidity and mortality in obese patients can be attributed to its association with the development of different life-threatening conditions. Plants are considered one of the most important sources of bioactive molecules which are used against a wide range of health disorders. This systematic review explores the efficacy as well as the safety profile of commonly used medicinal plants in the management of obesity that may help people to maintain a healthy weight. Methods: This review is based on comprehensive literature searches from PubMed, Science Direct, Scopus, and Google Scholar databases using the keywords- “plants in obesity”, “plants used in weight reduction” or keywords that are similar to those. Medicinal plants which have been clinically proven for their anti-obesity effect have only been selected for this study and attempts to investigate beneficial effects and adverse effects along with their mechanism of action have also been taken in this review. Results: A significant reduction of weight in both human and other animals are exhibited by the extracts of Phaseolus vulgaris, green coffee, Yerba Mate, green tea, Gynostemma pentaphyllum, and the combination of Cissus quadrangularis/Irvingia gabonensis. All of those plant extracts seemed to work on different physiological pathways and none of those extracts showed any notable adverse effects in human or animal models. Conclusion: Our review suggests that the discussed medicinal plants are effective in reducing the weight of obese patients without causing notable adverse reactions. Although further study is necessary to confirm their exact molecular mechanism and safety in human use.http://www.sciencedirect.com/science/article/pii/S2405844023007004ObesityWeight lossGreen coffeePhaseolus vulgarisYerba mateGreen tea |
| spellingShingle | Md Abdul Aziz Md Shalahuddin Millat Tahmina Akter Md Shahadat Hossain Md Monirul Islam Shahriar Mohsin Farzana Ansari Asma Kabir Mohammad Nurul Amin Mohammad Safiqul Islam A comprehensive review on clinically proven medicinal plants in the treatment of overweight and obesity, with mechanistic insights Heliyon Obesity Weight loss Green coffee Phaseolus vulgaris Yerba mate Green tea |
| title | A comprehensive review on clinically proven medicinal plants in the treatment of overweight and obesity, with mechanistic insights |
| title_full | A comprehensive review on clinically proven medicinal plants in the treatment of overweight and obesity, with mechanistic insights |
| title_fullStr | A comprehensive review on clinically proven medicinal plants in the treatment of overweight and obesity, with mechanistic insights |
| title_full_unstemmed | A comprehensive review on clinically proven medicinal plants in the treatment of overweight and obesity, with mechanistic insights |
| title_short | A comprehensive review on clinically proven medicinal plants in the treatment of overweight and obesity, with mechanistic insights |
| title_sort | comprehensive review on clinically proven medicinal plants in the treatment of overweight and obesity with mechanistic insights |
| topic | Obesity Weight loss Green coffee Phaseolus vulgaris Yerba mate Green tea |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023007004 |
| work_keys_str_mv | AT mdabdulaziz acomprehensivereviewonclinicallyprovenmedicinalplantsinthetreatmentofoverweightandobesitywithmechanisticinsights AT mdshalahuddinmillat acomprehensivereviewonclinicallyprovenmedicinalplantsinthetreatmentofoverweightandobesitywithmechanisticinsights AT tahminaakter acomprehensivereviewonclinicallyprovenmedicinalplantsinthetreatmentofoverweightandobesitywithmechanisticinsights AT mdshahadathossain acomprehensivereviewonclinicallyprovenmedicinalplantsinthetreatmentofoverweightandobesitywithmechanisticinsights AT mdmonirulislam acomprehensivereviewonclinicallyprovenmedicinalplantsinthetreatmentofoverweightandobesitywithmechanisticinsights AT shahriarmohsin acomprehensivereviewonclinicallyprovenmedicinalplantsinthetreatmentofoverweightandobesitywithmechanisticinsights AT farzanaansari acomprehensivereviewonclinicallyprovenmedicinalplantsinthetreatmentofoverweightandobesitywithmechanisticinsights AT asmakabir acomprehensivereviewonclinicallyprovenmedicinalplantsinthetreatmentofoverweightandobesitywithmechanisticinsights AT mohammadnurulamin acomprehensivereviewonclinicallyprovenmedicinalplantsinthetreatmentofoverweightandobesitywithmechanisticinsights AT mohammadsafiqulislam acomprehensivereviewonclinicallyprovenmedicinalplantsinthetreatmentofoverweightandobesitywithmechanisticinsights AT mdabdulaziz comprehensivereviewonclinicallyprovenmedicinalplantsinthetreatmentofoverweightandobesitywithmechanisticinsights AT mdshalahuddinmillat comprehensivereviewonclinicallyprovenmedicinalplantsinthetreatmentofoverweightandobesitywithmechanisticinsights AT tahminaakter comprehensivereviewonclinicallyprovenmedicinalplantsinthetreatmentofoverweightandobesitywithmechanisticinsights AT mdshahadathossain comprehensivereviewonclinicallyprovenmedicinalplantsinthetreatmentofoverweightandobesitywithmechanisticinsights AT mdmonirulislam comprehensivereviewonclinicallyprovenmedicinalplantsinthetreatmentofoverweightandobesitywithmechanisticinsights AT shahriarmohsin comprehensivereviewonclinicallyprovenmedicinalplantsinthetreatmentofoverweightandobesitywithmechanisticinsights AT farzanaansari comprehensivereviewonclinicallyprovenmedicinalplantsinthetreatmentofoverweightandobesitywithmechanisticinsights AT asmakabir comprehensivereviewonclinicallyprovenmedicinalplantsinthetreatmentofoverweightandobesitywithmechanisticinsights AT mohammadnurulamin comprehensivereviewonclinicallyprovenmedicinalplantsinthetreatmentofoverweightandobesitywithmechanisticinsights AT mohammadsafiqulislam comprehensivereviewonclinicallyprovenmedicinalplantsinthetreatmentofoverweightandobesitywithmechanisticinsights |