Non-Genomic Control of Dynamic MYCN Gene Expression in Liver Cancer
Upregulated MYCN gene expression is restricted to specialized cell populations such as EpCAM+ cancer stem cells in liver cancer, regardless of DNA amplification and mutation. Here, we reviewed the role of MYCN gene expression in liver homeostasis, regeneration, and tumorigenesis, and discussed the p...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.618515/full |
| _version_ | 1818442328442929152 |
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| author | Xian-Yang Qin Luc Gailhouste |
| author_facet | Xian-Yang Qin Luc Gailhouste |
| author_sort | Xian-Yang Qin |
| collection | DOAJ |
| description | Upregulated MYCN gene expression is restricted to specialized cell populations such as EpCAM+ cancer stem cells in liver cancer, regardless of DNA amplification and mutation. Here, we reviewed the role of MYCN gene expression in liver homeostasis, regeneration, and tumorigenesis, and discussed the potential non-genomic mechanisms involved in controlling MYCN gene expression in liver cancer, with a focus on inflammation-mediated signal transduction and microRNA-associated post-transcriptional regulation. We concluded that dynamic MYCN gene expression is an integrated consequence of multiple signals in the tumor microenvironment, including tumor growth-promoting signals, lipid desaturation-mediated endoplasmic reticulum stress adaptation signals, and tumor suppressive miRNAs, making it a potential predictive biomarker of tumor stemness and plasticity. Therefore, understanding and tracing the dynamic changes and functions of MYCN gene expression will shed light on the origin of liver tumorigenesis at the cellular level and the development of novel therapeutic and diagnostic strategies for liver cancer treatment. |
| first_indexed | 2024-12-14T18:42:24Z |
| format | Article |
| id | doaj.art-8fb0a91556904088a0bf0e0bb63fdbdb |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-14T18:42:24Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-8fb0a91556904088a0bf0e0bb63fdbdb2022-12-21T22:51:27ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-04-011010.3389/fonc.2020.618515618515Non-Genomic Control of Dynamic MYCN Gene Expression in Liver CancerXian-Yang QinLuc GailhousteUpregulated MYCN gene expression is restricted to specialized cell populations such as EpCAM+ cancer stem cells in liver cancer, regardless of DNA amplification and mutation. Here, we reviewed the role of MYCN gene expression in liver homeostasis, regeneration, and tumorigenesis, and discussed the potential non-genomic mechanisms involved in controlling MYCN gene expression in liver cancer, with a focus on inflammation-mediated signal transduction and microRNA-associated post-transcriptional regulation. We concluded that dynamic MYCN gene expression is an integrated consequence of multiple signals in the tumor microenvironment, including tumor growth-promoting signals, lipid desaturation-mediated endoplasmic reticulum stress adaptation signals, and tumor suppressive miRNAs, making it a potential predictive biomarker of tumor stemness and plasticity. Therefore, understanding and tracing the dynamic changes and functions of MYCN gene expression will shed light on the origin of liver tumorigenesis at the cellular level and the development of novel therapeutic and diagnostic strategies for liver cancer treatment.https://www.frontiersin.org/articles/10.3389/fonc.2020.618515/fullMYCNliver cancermicroenvironmentinflammationplasticitylipid desaturation |
| spellingShingle | Xian-Yang Qin Luc Gailhouste Non-Genomic Control of Dynamic MYCN Gene Expression in Liver Cancer Frontiers in Oncology MYCN liver cancer microenvironment inflammation plasticity lipid desaturation |
| title | Non-Genomic Control of Dynamic MYCN Gene Expression in Liver Cancer |
| title_full | Non-Genomic Control of Dynamic MYCN Gene Expression in Liver Cancer |
| title_fullStr | Non-Genomic Control of Dynamic MYCN Gene Expression in Liver Cancer |
| title_full_unstemmed | Non-Genomic Control of Dynamic MYCN Gene Expression in Liver Cancer |
| title_short | Non-Genomic Control of Dynamic MYCN Gene Expression in Liver Cancer |
| title_sort | non genomic control of dynamic mycn gene expression in liver cancer |
| topic | MYCN liver cancer microenvironment inflammation plasticity lipid desaturation |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2020.618515/full |
| work_keys_str_mv | AT xianyangqin nongenomiccontrolofdynamicmycngeneexpressioninlivercancer AT lucgailhouste nongenomiccontrolofdynamicmycngeneexpressioninlivercancer |