Uni and Multivariate Optimization for the Spectrophotometric Determination of Cimetidine Drug via Charge-Transfer Complex Formation
Charge transfer complex formation method has been applied for the spectrophotometric determination of cimetidine, in bulk sample and dosage form. The method was accurate, simple, rapid, inexpensive and sensitive depending on the formed charge- transfer complex between cited drug and, 2,3-Dichloro...
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| Format: | Article |
| Language: | English |
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University of Baghdad
2017-03-01
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| Series: | Ibn Al-Haitham Journal for Pure and Applied Sciences |
| Subjects: | |
| Online Access: | https://jih.uobaghdad.edu.iq/index.php/j/article/view/147 |
| _version_ | 1828285636539318272 |
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| author | Sarmad B. Dikran Alaa K. Mohammed Ali Kh. Mahmood |
| author_facet | Sarmad B. Dikran Alaa K. Mohammed Ali Kh. Mahmood |
| author_sort | Sarmad B. Dikran |
| collection | DOAJ |
| description |
Charge transfer complex formation method has been applied for the spectrophotometric determination of cimetidine, in bulk sample and dosage form. The method was accurate, simple, rapid, inexpensive and sensitive depending on the formed charge- transfer complex between cited drug and, 2,3-Dichloro-5,6-dicyano-p- benzoquinone (DDQ) as a chromogenic reagent. The formed complex shows absorbance maxima at 587 nm against reagent blank. The calibration graph is linear in the ranges of (5.0 - 50.0) µg.mL-1 with detection limit of 0.268µg.mL-1. The results show the absence of interferences from the excipients on the determination of the drug. Therefore the proposed method has been successfully applied for the determination of cimetidine in pharmaceutical preparations.
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| first_indexed | 2024-04-13T09:17:55Z |
| format | Article |
| id | doaj.art-8fb2c68255ef4748bac66c36379dcdc8 |
| institution | Directory Open Access Journal |
| issn | 1609-4042 2521-3407 |
| language | English |
| last_indexed | 2024-04-13T09:17:55Z |
| publishDate | 2017-03-01 |
| publisher | University of Baghdad |
| record_format | Article |
| series | Ibn Al-Haitham Journal for Pure and Applied Sciences |
| spelling | doaj.art-8fb2c68255ef4748bac66c36379dcdc82022-12-22T02:52:42ZengUniversity of BaghdadIbn Al-Haitham Journal for Pure and Applied Sciences1609-40422521-34072017-03-01283Uni and Multivariate Optimization for the Spectrophotometric Determination of Cimetidine Drug via Charge-Transfer Complex FormationSarmad B. DikranAlaa K. MohammedAli Kh. Mahmood Charge transfer complex formation method has been applied for the spectrophotometric determination of cimetidine, in bulk sample and dosage form. The method was accurate, simple, rapid, inexpensive and sensitive depending on the formed charge- transfer complex between cited drug and, 2,3-Dichloro-5,6-dicyano-p- benzoquinone (DDQ) as a chromogenic reagent. The formed complex shows absorbance maxima at 587 nm against reagent blank. The calibration graph is linear in the ranges of (5.0 - 50.0) µg.mL-1 with detection limit of 0.268µg.mL-1. The results show the absence of interferences from the excipients on the determination of the drug. Therefore the proposed method has been successfully applied for the determination of cimetidine in pharmaceutical preparations. https://jih.uobaghdad.edu.iq/index.php/j/article/view/147: Simplex, Spectrophotometric, Cimetidine , Charge- transfer. |
| spellingShingle | Sarmad B. Dikran Alaa K. Mohammed Ali Kh. Mahmood Uni and Multivariate Optimization for the Spectrophotometric Determination of Cimetidine Drug via Charge-Transfer Complex Formation Ibn Al-Haitham Journal for Pure and Applied Sciences : Simplex, Spectrophotometric, Cimetidine , Charge- transfer. |
| title | Uni and Multivariate Optimization for the Spectrophotometric Determination of Cimetidine Drug via Charge-Transfer Complex Formation |
| title_full | Uni and Multivariate Optimization for the Spectrophotometric Determination of Cimetidine Drug via Charge-Transfer Complex Formation |
| title_fullStr | Uni and Multivariate Optimization for the Spectrophotometric Determination of Cimetidine Drug via Charge-Transfer Complex Formation |
| title_full_unstemmed | Uni and Multivariate Optimization for the Spectrophotometric Determination of Cimetidine Drug via Charge-Transfer Complex Formation |
| title_short | Uni and Multivariate Optimization for the Spectrophotometric Determination of Cimetidine Drug via Charge-Transfer Complex Formation |
| title_sort | uni and multivariate optimization for the spectrophotometric determination of cimetidine drug via charge transfer complex formation |
| topic | : Simplex, Spectrophotometric, Cimetidine , Charge- transfer. |
| url | https://jih.uobaghdad.edu.iq/index.php/j/article/view/147 |
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