Proliferative changes of renal arteriolar walls induced by administration of angiotensin II receptor blocker are frequent in juvenile rats
Introduction: Our previous study of angiotensin II receptor blocker (ARB) administration in rats induced unusual proliferative changes of smooth muscle cells in renal arteriolar walls. The present study examined if the incidence of the changes depended on the rats’ age, and how long it would take to...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publications
2014-12-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320313502105 |
| _version_ | 1797282031389900800 |
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| author | Yohko Nagai Kazushige Nakanishi Tatsuo Akimoto Nobuaki Yamanaka |
| author_facet | Yohko Nagai Kazushige Nakanishi Tatsuo Akimoto Nobuaki Yamanaka |
| author_sort | Yohko Nagai |
| collection | DOAJ |
| description | Introduction: Our previous study of angiotensin II receptor blocker (ARB) administration in rats induced unusual proliferative changes of smooth muscle cells in renal arteriolar walls. The present study examined if the incidence of the changes depended on the rats’ age, and how long it would take to find changes. Materials and methods: Six-week-old (juvenile spontaneous hypertensive rats (SHRs)+ARB group, n =15) and 20-week-old (adult SHRs+ARB group, n =10) male SHRs were fed a standard diet (0.4% NaCl) containing valsartan (10 mg/kg/day; Novartis Co.). Fifteen age-matched SHRs were studied as controls. After 4, 8, and 12 weeks, the rat kidneys were examined under light and electron microscopes and through immunohistochemical studies. Results: Extremely concentric proliferative changes in afferent arteriolar walls were frequently observed in the juvenile SHR+ARB group compared to the adult SHR+ARB group (48.7±6.8% vs 19.3±6.9%; p =0.0307) at the 12 th week. Increased renin expression and arteriolar changes were found from the 4 th week in the juvenile SHR+ARB group. Conclusion: This study indicates that ARB administration induces unusual proliferative changes and a marked renin-producing cell increase in afferent arterioles more frequently in juveniles than adult rats. It is suggested that the treatment of ARB in juveniles might have a higher risk of changes in renal afferent arterioles. |
| first_indexed | 2024-03-07T17:06:05Z |
| format | Article |
| id | doaj.art-8fb390c4f64c4a43a192baafebc69edc |
| institution | Directory Open Access Journal |
| issn | 1470-3203 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T17:06:05Z |
| publishDate | 2014-12-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-8fb390c4f64c4a43a192baafebc69edc2024-03-03T02:37:14ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762014-12-011510.1177/1470320313502105Proliferative changes of renal arteriolar walls induced by administration of angiotensin II receptor blocker are frequent in juvenile ratsYohko Nagai0Kazushige Nakanishi1Tatsuo Akimoto2Nobuaki Yamanaka3Department of General Medicine and Emergency Care, Faculty of Medicine, Toho University, Tokyo, JapanDepartment of General Medicine and Emergency Care, Faculty of Medicine, Toho University, Tokyo, JapanDepartment of General Medicine and Emergency Care, Faculty of Medicine, Toho University, Tokyo, JapanTokyo Kidney Research Institute, Tokyo, JapanIntroduction: Our previous study of angiotensin II receptor blocker (ARB) administration in rats induced unusual proliferative changes of smooth muscle cells in renal arteriolar walls. The present study examined if the incidence of the changes depended on the rats’ age, and how long it would take to find changes. Materials and methods: Six-week-old (juvenile spontaneous hypertensive rats (SHRs)+ARB group, n =15) and 20-week-old (adult SHRs+ARB group, n =10) male SHRs were fed a standard diet (0.4% NaCl) containing valsartan (10 mg/kg/day; Novartis Co.). Fifteen age-matched SHRs were studied as controls. After 4, 8, and 12 weeks, the rat kidneys were examined under light and electron microscopes and through immunohistochemical studies. Results: Extremely concentric proliferative changes in afferent arteriolar walls were frequently observed in the juvenile SHR+ARB group compared to the adult SHR+ARB group (48.7±6.8% vs 19.3±6.9%; p =0.0307) at the 12 th week. Increased renin expression and arteriolar changes were found from the 4 th week in the juvenile SHR+ARB group. Conclusion: This study indicates that ARB administration induces unusual proliferative changes and a marked renin-producing cell increase in afferent arterioles more frequently in juveniles than adult rats. It is suggested that the treatment of ARB in juveniles might have a higher risk of changes in renal afferent arterioles.https://doi.org/10.1177/1470320313502105 |
| spellingShingle | Yohko Nagai Kazushige Nakanishi Tatsuo Akimoto Nobuaki Yamanaka Proliferative changes of renal arteriolar walls induced by administration of angiotensin II receptor blocker are frequent in juvenile rats Journal of the Renin-Angiotensin-Aldosterone System |
| title | Proliferative changes of renal arteriolar walls induced by administration of angiotensin II receptor blocker are frequent in juvenile rats |
| title_full | Proliferative changes of renal arteriolar walls induced by administration of angiotensin II receptor blocker are frequent in juvenile rats |
| title_fullStr | Proliferative changes of renal arteriolar walls induced by administration of angiotensin II receptor blocker are frequent in juvenile rats |
| title_full_unstemmed | Proliferative changes of renal arteriolar walls induced by administration of angiotensin II receptor blocker are frequent in juvenile rats |
| title_short | Proliferative changes of renal arteriolar walls induced by administration of angiotensin II receptor blocker are frequent in juvenile rats |
| title_sort | proliferative changes of renal arteriolar walls induced by administration of angiotensin ii receptor blocker are frequent in juvenile rats |
| url | https://doi.org/10.1177/1470320313502105 |
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