Enantioselective Toxicity of Tetramethrin to Different Developmental Stages of Zebrafish (<i>Danio rerio</i>)
Chiral pesticides exhibit enantioselective differences in processes such as biological absorption, metabolism, and toxic effects. Organisms have different physiological characteristics at different developmental stages. Therefore, conducting enantiomeric toxicity studies at different developmental s...
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MDPI AG
2024-02-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/12/2/146 |
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| author | Jiqin Feng Xintong Xu Wenfei Huang Honghong Gong Xiaohui Sun Jinsong Liu Chao Xu Weiping Liu |
| author_facet | Jiqin Feng Xintong Xu Wenfei Huang Honghong Gong Xiaohui Sun Jinsong Liu Chao Xu Weiping Liu |
| author_sort | Jiqin Feng |
| collection | DOAJ |
| description | Chiral pesticides exhibit enantioselective differences in processes such as biological absorption, metabolism, and toxic effects. Organisms have different physiological characteristics at different developmental stages. Therefore, conducting enantiomeric toxicity studies at different developmental stages of organisms can help deepen the understanding of the ecological effects of chiral pesticides. This study focused on <i>trans</i>-tetramethrin (Tet) and investigated the enantioselectivity in bioconcentration, developmental toxicity, estrogenic effects, and immunotoxicity of Tet’s racemate ((±)-Tet) and its two enantiomers ((+)-Tet and (−)-Tet) in three developmental stages of zebrafish: embryos, yolk sac larvae, and juveniles. The results showed that Tet exhibited different enantioselectivity in lethal, bioconcentration, and teratogenic effects on zebrafish at different developmental stages. The LC<sub>50</sub> value was (+)-Tet > (±)-Tet > (−)-Tet, with embryos being the most sensitive, followed by juveniles and yolk sac larvae. The enantioselective bioconcentration was (±)-Tet > (+)-Tet > (−)-Tet, and the bioconcentration effect was greater in embryos than that in yolk sac larvae and juveniles. Developmental toxicity indicated that (+)-Tet and (±)-Tet had higher teratogenic effects on yolk sac larvae than on embryos. Tet exhibited different enantioselective effects on the expression of zebrafish estrogen-related genes and innate immune-related genes at different developmental stages. These results will contribute to a more comprehensive assessment of the aquatic toxicity and environmental risks of chiral pesticides. |
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| language | English |
| last_indexed | 2024-03-07T22:12:13Z |
| publishDate | 2024-02-01 |
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| series | Toxics |
| spelling | doaj.art-8fb3f0b3ffec4a2db2f5992896d1a2812024-02-23T15:36:26ZengMDPI AGToxics2305-63042024-02-0112214610.3390/toxics12020146Enantioselective Toxicity of Tetramethrin to Different Developmental Stages of Zebrafish (<i>Danio rerio</i>)Jiqin Feng0Xintong Xu1Wenfei Huang2Honghong Gong3Xiaohui Sun4Jinsong Liu5Chao Xu6Weiping Liu7Zhejiang Environment Technology Co., Ltd., Hangzhou 310000, ChinaZhejiang Environment Technology Co., Ltd., Hangzhou 310000, ChinaEco-Environmental Science Research & Design Institute of Zhejiang Province, Hangzhou 310007, ChinaCollege of Environment, Zhejiang University of Technology, Hangzhou 310032, ChinaZhejiang Environmental Monitoring Center, Hangzhou 310012, ChinaZhejiang Environmental Monitoring Center, Hangzhou 310012, ChinaCollege of Environment, Zhejiang University of Technology, Hangzhou 310032, ChinaKey Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, Interdisciplinary Research Academy (IRA), Zhejiang Shuren University, Hangzhou 310015, ChinaChiral pesticides exhibit enantioselective differences in processes such as biological absorption, metabolism, and toxic effects. Organisms have different physiological characteristics at different developmental stages. Therefore, conducting enantiomeric toxicity studies at different developmental stages of organisms can help deepen the understanding of the ecological effects of chiral pesticides. This study focused on <i>trans</i>-tetramethrin (Tet) and investigated the enantioselectivity in bioconcentration, developmental toxicity, estrogenic effects, and immunotoxicity of Tet’s racemate ((±)-Tet) and its two enantiomers ((+)-Tet and (−)-Tet) in three developmental stages of zebrafish: embryos, yolk sac larvae, and juveniles. The results showed that Tet exhibited different enantioselectivity in lethal, bioconcentration, and teratogenic effects on zebrafish at different developmental stages. The LC<sub>50</sub> value was (+)-Tet > (±)-Tet > (−)-Tet, with embryos being the most sensitive, followed by juveniles and yolk sac larvae. The enantioselective bioconcentration was (±)-Tet > (+)-Tet > (−)-Tet, and the bioconcentration effect was greater in embryos than that in yolk sac larvae and juveniles. Developmental toxicity indicated that (+)-Tet and (±)-Tet had higher teratogenic effects on yolk sac larvae than on embryos. Tet exhibited different enantioselective effects on the expression of zebrafish estrogen-related genes and innate immune-related genes at different developmental stages. These results will contribute to a more comprehensive assessment of the aquatic toxicity and environmental risks of chiral pesticides.https://www.mdpi.com/2305-6304/12/2/146pyrethroidenantioselectivityendocrineimmunotoxicitylife stages |
| spellingShingle | Jiqin Feng Xintong Xu Wenfei Huang Honghong Gong Xiaohui Sun Jinsong Liu Chao Xu Weiping Liu Enantioselective Toxicity of Tetramethrin to Different Developmental Stages of Zebrafish (<i>Danio rerio</i>) Toxics pyrethroid enantioselectivity endocrine immunotoxicity life stages |
| title | Enantioselective Toxicity of Tetramethrin to Different Developmental Stages of Zebrafish (<i>Danio rerio</i>) |
| title_full | Enantioselective Toxicity of Tetramethrin to Different Developmental Stages of Zebrafish (<i>Danio rerio</i>) |
| title_fullStr | Enantioselective Toxicity of Tetramethrin to Different Developmental Stages of Zebrafish (<i>Danio rerio</i>) |
| title_full_unstemmed | Enantioselective Toxicity of Tetramethrin to Different Developmental Stages of Zebrafish (<i>Danio rerio</i>) |
| title_short | Enantioselective Toxicity of Tetramethrin to Different Developmental Stages of Zebrafish (<i>Danio rerio</i>) |
| title_sort | enantioselective toxicity of tetramethrin to different developmental stages of zebrafish i danio rerio i |
| topic | pyrethroid enantioselectivity endocrine immunotoxicity life stages |
| url | https://www.mdpi.com/2305-6304/12/2/146 |
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