Acquired Factor V Deficiency After Carbapenem Administration: A Case Report
Factor V (FV) deficiency is a coagulation disorder (congenital or acquired). Unlike congenital FV deficiency, mixing tests for prothrombin time and activated partial thromboplastin time are not corrected in acquired FV cases. A 79-year-old male was admitted to the intensive care unit after an emerge...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Society of Acute Care Surgery
2024-03-01
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| Series: | Journal of Acute Care Surgery |
| Subjects: | |
| Online Access: | http://www.jacs.or.kr/upload/pdf/jacs-2024-14-1-37.pdf |
| _version_ | 1797243167466061824 |
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| author | Hyejeong Park Jee Yeon Lee Im-kyung Kim |
| author_facet | Hyejeong Park Jee Yeon Lee Im-kyung Kim |
| author_sort | Hyejeong Park |
| collection | DOAJ |
| description | Factor V (FV) deficiency is a coagulation disorder (congenital or acquired). Unlike congenital FV deficiency, mixing tests for prothrombin time and activated partial thromboplastin time are not corrected in acquired FV cases. A 79-year-old male was admitted to the intensive care unit after an emergency operation due to gastric ulcer perforation. While receiving antibiotic treatment for septic shock, the coagulation profile began to show prolongation of prothrombin time and activated partial thromboplastin time. FV deficiency (< 1%) following meropenem administration was diagnosed. The patient did not show spontaneous bleeding or bleeding tendency. With fresh frozen plasma transfusion, steroid administration, and discontinuation of meropenem, the blood coagulation profile test result was normalized 20 days after diagnosis. His follow-up FV level increased to 78.7%. Although abnormalities in coagulation profiles are common in sepsis patients, in our patient, timely recognition and hematological consultation allowed early diagnosis and proper management of FV deficiency. |
| first_indexed | 2024-04-24T18:50:49Z |
| format | Article |
| id | doaj.art-8fb6b81c43e74410a55debe3db0fb58f |
| institution | Directory Open Access Journal |
| issn | 2288-5862 2288-9582 |
| language | English |
| last_indexed | 2024-04-24T18:50:49Z |
| publishDate | 2024-03-01 |
| publisher | Korean Society of Acute Care Surgery |
| record_format | Article |
| series | Journal of Acute Care Surgery |
| spelling | doaj.art-8fb6b81c43e74410a55debe3db0fb58f2024-03-27T01:49:58ZengKorean Society of Acute Care SurgeryJournal of Acute Care Surgery2288-58622288-95822024-03-01141374010.17479/jacs.2024.14.1.37293Acquired Factor V Deficiency After Carbapenem Administration: A Case ReportHyejeong Park0Jee Yeon Lee1Im-kyung Kim2Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of KoreaDepartment of Surgery, Yonsei University College of Medicine, Seoul, Republic of KoreaDepartment of Surgery, Yonsei University College of Medicine, Seoul, Republic of KoreaFactor V (FV) deficiency is a coagulation disorder (congenital or acquired). Unlike congenital FV deficiency, mixing tests for prothrombin time and activated partial thromboplastin time are not corrected in acquired FV cases. A 79-year-old male was admitted to the intensive care unit after an emergency operation due to gastric ulcer perforation. While receiving antibiotic treatment for septic shock, the coagulation profile began to show prolongation of prothrombin time and activated partial thromboplastin time. FV deficiency (< 1%) following meropenem administration was diagnosed. The patient did not show spontaneous bleeding or bleeding tendency. With fresh frozen plasma transfusion, steroid administration, and discontinuation of meropenem, the blood coagulation profile test result was normalized 20 days after diagnosis. His follow-up FV level increased to 78.7%. Although abnormalities in coagulation profiles are common in sepsis patients, in our patient, timely recognition and hematological consultation allowed early diagnosis and proper management of FV deficiency.http://www.jacs.or.kr/upload/pdf/jacs-2024-14-1-37.pdfcarbapenemfactor v deficiencysepsis |
| spellingShingle | Hyejeong Park Jee Yeon Lee Im-kyung Kim Acquired Factor V Deficiency After Carbapenem Administration: A Case Report Journal of Acute Care Surgery carbapenem factor v deficiency sepsis |
| title | Acquired Factor V Deficiency After Carbapenem Administration: A Case Report |
| title_full | Acquired Factor V Deficiency After Carbapenem Administration: A Case Report |
| title_fullStr | Acquired Factor V Deficiency After Carbapenem Administration: A Case Report |
| title_full_unstemmed | Acquired Factor V Deficiency After Carbapenem Administration: A Case Report |
| title_short | Acquired Factor V Deficiency After Carbapenem Administration: A Case Report |
| title_sort | acquired factor v deficiency after carbapenem administration a case report |
| topic | carbapenem factor v deficiency sepsis |
| url | http://www.jacs.or.kr/upload/pdf/jacs-2024-14-1-37.pdf |
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