A Comprehensive Review of Inorganic Sonosensitizers for Sonodynamic Therapy
Sonodynamic therapy (SDT) is an emerging non-invasive cancer treatment method in the field of nanomedicine, which has the advantages of deep penetration, good therapeutic efficacy, and minimal damage to normal tissues. Sonosensitizers play a crucial role in the process of SDT, as their structure and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/15/12001 |
| _version_ | 1797586687997509632 |
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| author | Peng Chen Ping Zhang Navid Hussain Shah Yanyan Cui Yaling Wang |
| author_facet | Peng Chen Ping Zhang Navid Hussain Shah Yanyan Cui Yaling Wang |
| author_sort | Peng Chen |
| collection | DOAJ |
| description | Sonodynamic therapy (SDT) is an emerging non-invasive cancer treatment method in the field of nanomedicine, which has the advantages of deep penetration, good therapeutic efficacy, and minimal damage to normal tissues. Sonosensitizers play a crucial role in the process of SDT, as their structure and properties directly determine the treatment outcome. Inorganic sonosensitizers, with their high stability and longer circulation time in the human body, have great potential in SDT. In this review, the possible mechanisms of SDT including the ultrasonic cavitation, reactive oxygen species generation, and activation of immunity are briefly discussed. Then, the latest research progress on inorganic sonosensitizers is systematically summarized. Subsequently, strategies for optimizing treatment efficacy are introduced, including combination therapy and image-guided therapy. The challenges and future prospects of sonodynamic therapy are discussed. It is hoped that this review will provide some guidance for the screening of inorganic sonosensitizers. |
| first_indexed | 2024-03-11T00:26:37Z |
| format | Article |
| id | doaj.art-8fb6ed635bee481d9f00910828e9fa67 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T00:26:37Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8fb6ed635bee481d9f00910828e9fa672023-11-18T22:59:01ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-07-0124151200110.3390/ijms241512001A Comprehensive Review of Inorganic Sonosensitizers for Sonodynamic TherapyPeng Chen0Ping Zhang1Navid Hussain Shah2Yanyan Cui3Yaling Wang4Beijing Engineering Research Center of Mixed Reality and Advanced Display, School of Optics and Photonics, Beijing Institute of Technology, Beijing 100081, ChinaBeijing Engineering Research Center of Mixed Reality and Advanced Display, School of Optics and Photonics, Beijing Institute of Technology, Beijing 100081, ChinaBeijing Engineering Research Center of Mixed Reality and Advanced Display, School of Optics and Photonics, Beijing Institute of Technology, Beijing 100081, ChinaBeijing Engineering Research Center of Mixed Reality and Advanced Display, School of Optics and Photonics, Beijing Institute of Technology, Beijing 100081, ChinaCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, ChinaSonodynamic therapy (SDT) is an emerging non-invasive cancer treatment method in the field of nanomedicine, which has the advantages of deep penetration, good therapeutic efficacy, and minimal damage to normal tissues. Sonosensitizers play a crucial role in the process of SDT, as their structure and properties directly determine the treatment outcome. Inorganic sonosensitizers, with their high stability and longer circulation time in the human body, have great potential in SDT. In this review, the possible mechanisms of SDT including the ultrasonic cavitation, reactive oxygen species generation, and activation of immunity are briefly discussed. Then, the latest research progress on inorganic sonosensitizers is systematically summarized. Subsequently, strategies for optimizing treatment efficacy are introduced, including combination therapy and image-guided therapy. The challenges and future prospects of sonodynamic therapy are discussed. It is hoped that this review will provide some guidance for the screening of inorganic sonosensitizers.https://www.mdpi.com/1422-0067/24/15/12001sonodynamic therapySDT mechanismsinorganic sonosensitizerscombination therapy |
| spellingShingle | Peng Chen Ping Zhang Navid Hussain Shah Yanyan Cui Yaling Wang A Comprehensive Review of Inorganic Sonosensitizers for Sonodynamic Therapy International Journal of Molecular Sciences sonodynamic therapy SDT mechanisms inorganic sonosensitizers combination therapy |
| title | A Comprehensive Review of Inorganic Sonosensitizers for Sonodynamic Therapy |
| title_full | A Comprehensive Review of Inorganic Sonosensitizers for Sonodynamic Therapy |
| title_fullStr | A Comprehensive Review of Inorganic Sonosensitizers for Sonodynamic Therapy |
| title_full_unstemmed | A Comprehensive Review of Inorganic Sonosensitizers for Sonodynamic Therapy |
| title_short | A Comprehensive Review of Inorganic Sonosensitizers for Sonodynamic Therapy |
| title_sort | comprehensive review of inorganic sonosensitizers for sonodynamic therapy |
| topic | sonodynamic therapy SDT mechanisms inorganic sonosensitizers combination therapy |
| url | https://www.mdpi.com/1422-0067/24/15/12001 |
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