Effects of the Continuous Administration of an Agaricus blazei Extract to Rats on Oxidative Parameters of the Brain and Liver during Aging
An investigation of the effects of an aqueous extract of Agaricus blazei, a medicinal mushroom, on the oxidative state of the brain and liver of rats during aging (7 to 23 months) was conducted. The treatment consisted in the daily intragastric administration of 50 mg/kg of the extract. The A. blaze...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2014-11-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/19/11/18590 |
| _version_ | 1818297342063804416 |
|---|---|
| author | Anacharis B. de Sá-Nakanishi Andréia A. Soares Maria R. M. Natali Jurandir Fernando Comar Rosane M. Peralta Adelar Bracht |
| author_facet | Anacharis B. de Sá-Nakanishi Andréia A. Soares Maria R. M. Natali Jurandir Fernando Comar Rosane M. Peralta Adelar Bracht |
| author_sort | Anacharis B. de Sá-Nakanishi |
| collection | DOAJ |
| description | An investigation of the effects of an aqueous extract of Agaricus blazei, a medicinal mushroom, on the oxidative state of the brain and liver of rats during aging (7 to 23 months) was conducted. The treatment consisted in the daily intragastric administration of 50 mg/kg of the extract. The A. blazei treatment tended to maintain the ROS contents of the brain and liver at lower levels, but a significant difference was found only at the age of 23 months and in the brain. The TBARS levels in the brain were maintained at lower levels by the A. blazei treatment during the whole aging process with a specially pronounced difference at the age of 12 months. The total antioxidant capacity in the brain was higher in treated rats only at the age of 12 months. Compared with previous studies in which old rats (21 months) were treated during a short period of 21 days with 200 mg/kg, the effects of the A. blazei extract in the present study tended to be less pronounced. The results also indicate that the long and constant treatment presented a tendency of becoming less effective at ages above 12 months. |
| first_indexed | 2024-12-13T04:17:54Z |
| format | Article |
| id | doaj.art-8fb70967ee934514871ee7cc2cc086b3 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-13T04:17:54Z |
| publishDate | 2014-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-8fb70967ee934514871ee7cc2cc086b32022-12-21T23:59:50ZengMDPI AGMolecules1420-30492014-11-011911185901860310.3390/molecules191118590molecules191118590Effects of the Continuous Administration of an Agaricus blazei Extract to Rats on Oxidative Parameters of the Brain and Liver during AgingAnacharis B. de Sá-Nakanishi0Andréia A. Soares1Maria R. M. Natali2Jurandir Fernando Comar3Rosane M. Peralta4Adelar Bracht5Department of Biochemistry, State University of Maringá, 87020900 Maringá, BrazilDepartment of Biochemistry, State University of Maringá, 87020900 Maringá, BrazilDepartment of Morphological Sciences, State University of Maringá, 87020900 Maringá, BrazilDepartment of Biochemistry, State University of Maringá, 87020900 Maringá, BrazilDepartment of Biochemistry, State University of Maringá, 87020900 Maringá, BrazilDepartment of Biochemistry, State University of Maringá, 87020900 Maringá, BrazilAn investigation of the effects of an aqueous extract of Agaricus blazei, a medicinal mushroom, on the oxidative state of the brain and liver of rats during aging (7 to 23 months) was conducted. The treatment consisted in the daily intragastric administration of 50 mg/kg of the extract. The A. blazei treatment tended to maintain the ROS contents of the brain and liver at lower levels, but a significant difference was found only at the age of 23 months and in the brain. The TBARS levels in the brain were maintained at lower levels by the A. blazei treatment during the whole aging process with a specially pronounced difference at the age of 12 months. The total antioxidant capacity in the brain was higher in treated rats only at the age of 12 months. Compared with previous studies in which old rats (21 months) were treated during a short period of 21 days with 200 mg/kg, the effects of the A. blazei extract in the present study tended to be less pronounced. The results also indicate that the long and constant treatment presented a tendency of becoming less effective at ages above 12 months.http://www.mdpi.com/1420-3049/19/11/18590agingoxidative stressoxidative damagebrainliverA. blazei treatment |
| spellingShingle | Anacharis B. de Sá-Nakanishi Andréia A. Soares Maria R. M. Natali Jurandir Fernando Comar Rosane M. Peralta Adelar Bracht Effects of the Continuous Administration of an Agaricus blazei Extract to Rats on Oxidative Parameters of the Brain and Liver during Aging Molecules aging oxidative stress oxidative damage brain liver A. blazei treatment |
| title | Effects of the Continuous Administration of an Agaricus blazei Extract to Rats on Oxidative Parameters of the Brain and Liver during Aging |
| title_full | Effects of the Continuous Administration of an Agaricus blazei Extract to Rats on Oxidative Parameters of the Brain and Liver during Aging |
| title_fullStr | Effects of the Continuous Administration of an Agaricus blazei Extract to Rats on Oxidative Parameters of the Brain and Liver during Aging |
| title_full_unstemmed | Effects of the Continuous Administration of an Agaricus blazei Extract to Rats on Oxidative Parameters of the Brain and Liver during Aging |
| title_short | Effects of the Continuous Administration of an Agaricus blazei Extract to Rats on Oxidative Parameters of the Brain and Liver during Aging |
| title_sort | effects of the continuous administration of an agaricus blazei extract to rats on oxidative parameters of the brain and liver during aging |
| topic | aging oxidative stress oxidative damage brain liver A. blazei treatment |
| url | http://www.mdpi.com/1420-3049/19/11/18590 |
| work_keys_str_mv | AT anacharisbdesanakanishi effectsofthecontinuousadministrationofanagaricusblazeiextracttoratsonoxidativeparametersofthebrainandliverduringaging AT andreiaasoares effectsofthecontinuousadministrationofanagaricusblazeiextracttoratsonoxidativeparametersofthebrainandliverduringaging AT mariarmnatali effectsofthecontinuousadministrationofanagaricusblazeiextracttoratsonoxidativeparametersofthebrainandliverduringaging AT jurandirfernandocomar effectsofthecontinuousadministrationofanagaricusblazeiextracttoratsonoxidativeparametersofthebrainandliverduringaging AT rosanemperalta effectsofthecontinuousadministrationofanagaricusblazeiextracttoratsonoxidativeparametersofthebrainandliverduringaging AT adelarbracht effectsofthecontinuousadministrationofanagaricusblazeiextracttoratsonoxidativeparametersofthebrainandliverduringaging |