Association of Non High Density Lipoprotein-Cholesterol and HbA1c in Type 2 Diabetes Mellitus
Background: Dyslipidemia is a common issue among diabetic patients and is associated with an increased risk of cardiovascular disease. Non-High Density Lipoprotein-cholesterol has emerged as a valuable marker for assessing combined cardiovascular risk in diabetes. Measures to improve the Non-High De...
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| Format: | Article |
| Language: | English |
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Nobel Medical College Teaching Hospital
2023-12-01
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| Series: | Journal of Nobel Medical College |
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| Online Access: | https://www.nepjol.info/index.php/JoNMC/article/view/61111 |
| _version_ | 1797350215962853376 |
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| author | Saroj Thapa Nirish Vaidya Rachana Pandey Jyoti Shrestha Takanche |
| author_facet | Saroj Thapa Nirish Vaidya Rachana Pandey Jyoti Shrestha Takanche |
| author_sort | Saroj Thapa |
| collection | DOAJ |
| description | Background: Dyslipidemia is a common issue among diabetic patients and is associated with an increased risk of cardiovascular disease. Non-High Density Lipoprotein-cholesterol has emerged as a valuable marker for assessing combined cardiovascular risk in diabetes. Measures to improve the Non-High Density Lipoprotein-cholesterol within optimal level might improve the glycemic status and decrease the cardiovascular risk. This study aims to examine the relationship between Non-High Density Lipoprotein-cholesterol and glycated hemoglobin levels in type 2 diabetic patients.
Materials and Methods: A hospital-based comparative cross-sectional study was conducted on 544 individuals diagnosed with type 2 diabetes. The classification of lipid profile and glycemic control was carried out as per the National Cholesterol Education Program Adult Treatment Plan III and American Diabetes Association guidelines.
Results: Our study found that Non-High Density Lipoprotein-cholesterol levels was higher in uncontrolled diabetes (157.9±46.8) compared to controlled diabetes (132.6±40.6), with a statistically significant difference (P<0.001). There was a weak positive correlation between Non-High Density Lipoprotein-cholesterol and glycated hemoglobin levels (r=0.37).Among the total participants, 226 (41.5%) had optimal Non-High Density Lipoprotein-cholesterol level whereas 318 (58.5%) had high Non-High Density Lipoprotein-cholesterol.
Conclusion: This study confirms a positive correlation between Non-High Density Lipoprotein-cholesterol and HbA1c levels in type 2 diabetic patients. Dyslipidemia prevalence was substantial, emphasizing the importance of achieving target Non-High Density Lipoprotein-cholesterol levels for improved glycemic control and cardiovascular risk reduction. |
| first_indexed | 2024-03-08T12:41:29Z |
| format | Article |
| id | doaj.art-8fb7dbf492984e5aba0214e5a5bff2fc |
| institution | Directory Open Access Journal |
| issn | 2091-2331 2091-234X |
| language | English |
| last_indexed | 2024-03-08T12:41:29Z |
| publishDate | 2023-12-01 |
| publisher | Nobel Medical College Teaching Hospital |
| record_format | Article |
| series | Journal of Nobel Medical College |
| spelling | doaj.art-8fb7dbf492984e5aba0214e5a5bff2fc2024-01-21T09:26:59ZengNobel Medical College Teaching HospitalJournal of Nobel Medical College2091-23312091-234X2023-12-01122303510.3126/jonmc.v12i2.6111188226Association of Non High Density Lipoprotein-Cholesterol and HbA1c in Type 2 Diabetes MellitusSaroj Thapa0https://orcid.org/0000-0003-1234-644XNirish Vaidya1Rachana Pandey2Jyoti Shrestha Takanche3Department of Clinical Biochemistry, Kathmandu University School of Medical Sciences, Dhulikhel, NepalDepartment of Internal Medicine, Kathmandu University School of Medical Sciences, Dhulikhel, NepalDepartment of Clinical Biochemistry, Kathmandu University School of Medical Sciences, Dhulikhel, NepalDepartment of Clinical Biochemistry, Kathmandu University School of Medical Sciences, Dhulikhel, NepalBackground: Dyslipidemia is a common issue among diabetic patients and is associated with an increased risk of cardiovascular disease. Non-High Density Lipoprotein-cholesterol has emerged as a valuable marker for assessing combined cardiovascular risk in diabetes. Measures to improve the Non-High Density Lipoprotein-cholesterol within optimal level might improve the glycemic status and decrease the cardiovascular risk. This study aims to examine the relationship between Non-High Density Lipoprotein-cholesterol and glycated hemoglobin levels in type 2 diabetic patients. Materials and Methods: A hospital-based comparative cross-sectional study was conducted on 544 individuals diagnosed with type 2 diabetes. The classification of lipid profile and glycemic control was carried out as per the National Cholesterol Education Program Adult Treatment Plan III and American Diabetes Association guidelines. Results: Our study found that Non-High Density Lipoprotein-cholesterol levels was higher in uncontrolled diabetes (157.9±46.8) compared to controlled diabetes (132.6±40.6), with a statistically significant difference (P<0.001). There was a weak positive correlation between Non-High Density Lipoprotein-cholesterol and glycated hemoglobin levels (r=0.37).Among the total participants, 226 (41.5%) had optimal Non-High Density Lipoprotein-cholesterol level whereas 318 (58.5%) had high Non-High Density Lipoprotein-cholesterol. Conclusion: This study confirms a positive correlation between Non-High Density Lipoprotein-cholesterol and HbA1c levels in type 2 diabetic patients. Dyslipidemia prevalence was substantial, emphasizing the importance of achieving target Non-High Density Lipoprotein-cholesterol levels for improved glycemic control and cardiovascular risk reduction.https://www.nepjol.info/index.php/JoNMC/article/view/61111dyslipidemiaglycated hemoglobintype 2 diabetes |
| spellingShingle | Saroj Thapa Nirish Vaidya Rachana Pandey Jyoti Shrestha Takanche Association of Non High Density Lipoprotein-Cholesterol and HbA1c in Type 2 Diabetes Mellitus Journal of Nobel Medical College dyslipidemia glycated hemoglobin type 2 diabetes |
| title | Association of Non High Density Lipoprotein-Cholesterol and HbA1c in Type 2 Diabetes Mellitus |
| title_full | Association of Non High Density Lipoprotein-Cholesterol and HbA1c in Type 2 Diabetes Mellitus |
| title_fullStr | Association of Non High Density Lipoprotein-Cholesterol and HbA1c in Type 2 Diabetes Mellitus |
| title_full_unstemmed | Association of Non High Density Lipoprotein-Cholesterol and HbA1c in Type 2 Diabetes Mellitus |
| title_short | Association of Non High Density Lipoprotein-Cholesterol and HbA1c in Type 2 Diabetes Mellitus |
| title_sort | association of non high density lipoprotein cholesterol and hba1c in type 2 diabetes mellitus |
| topic | dyslipidemia glycated hemoglobin type 2 diabetes |
| url | https://www.nepjol.info/index.php/JoNMC/article/view/61111 |
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