Transcriptional regulation is a major controller of cell cycle transition dynamics.
DNA replication, mitosis and mitotic exit are critical transitions of the cell cycle which normally occur only once per cycle. A universal control mechanism was proposed for the regulation of mitotic entry in which Cdk helps its own activation through two positive feedback loops. Recent discoveries...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22238641/pdf/?tool=EBI |
| _version_ | 1818993137869127680 |
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| author | Alessandro Romanel Alessandro Romanel Lars Juhl Jensen Luca Cardelli Attila Csikász-Nagy |
| author_facet | Alessandro Romanel Alessandro Romanel Lars Juhl Jensen Luca Cardelli Attila Csikász-Nagy |
| author_sort | Alessandro Romanel |
| collection | DOAJ |
| description | DNA replication, mitosis and mitotic exit are critical transitions of the cell cycle which normally occur only once per cycle. A universal control mechanism was proposed for the regulation of mitotic entry in which Cdk helps its own activation through two positive feedback loops. Recent discoveries in various organisms showed the importance of positive feedbacks in other transitions as well. Here we investigate if a universal control system with transcriptional regulation(s) and post-translational positive feedback(s) can be proposed for the regulation of all cell cycle transitions. Through computational modeling, we analyze the transition dynamics in all possible combinations of transcriptional and post-translational regulations. We find that some combinations lead to 'sloppy' transitions, while others give very precise control. The periodic transcriptional regulation through the activator or the inhibitor leads to radically different dynamics. Experimental evidence shows that in cell cycle transitions of organisms investigated for cell cycle dependent periodic transcription, only the inhibitor OR the activator is under cyclic control and never both of them. Based on these observations, we propose two transcriptional control modes of cell cycle regulation that either STOP or let the cycle GO in case of a transcriptional failure. We discuss the biological relevance of such differences. |
| first_indexed | 2024-12-20T20:37:17Z |
| format | Article |
| id | doaj.art-8fbbe216d7a347c69b8832ad8c46fbb9 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T20:37:17Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-8fbbe216d7a347c69b8832ad8c46fbb92022-12-21T19:27:12ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0171e2971610.1371/journal.pone.0029716Transcriptional regulation is a major controller of cell cycle transition dynamics.Alessandro RomanelAlessandro RomanelLars Juhl JensenLuca CardelliAttila Csikász-NagyDNA replication, mitosis and mitotic exit are critical transitions of the cell cycle which normally occur only once per cycle. A universal control mechanism was proposed for the regulation of mitotic entry in which Cdk helps its own activation through two positive feedback loops. Recent discoveries in various organisms showed the importance of positive feedbacks in other transitions as well. Here we investigate if a universal control system with transcriptional regulation(s) and post-translational positive feedback(s) can be proposed for the regulation of all cell cycle transitions. Through computational modeling, we analyze the transition dynamics in all possible combinations of transcriptional and post-translational regulations. We find that some combinations lead to 'sloppy' transitions, while others give very precise control. The periodic transcriptional regulation through the activator or the inhibitor leads to radically different dynamics. Experimental evidence shows that in cell cycle transitions of organisms investigated for cell cycle dependent periodic transcription, only the inhibitor OR the activator is under cyclic control and never both of them. Based on these observations, we propose two transcriptional control modes of cell cycle regulation that either STOP or let the cycle GO in case of a transcriptional failure. We discuss the biological relevance of such differences.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22238641/pdf/?tool=EBI |
| spellingShingle | Alessandro Romanel Alessandro Romanel Lars Juhl Jensen Luca Cardelli Attila Csikász-Nagy Transcriptional regulation is a major controller of cell cycle transition dynamics. PLoS ONE |
| title | Transcriptional regulation is a major controller of cell cycle transition dynamics. |
| title_full | Transcriptional regulation is a major controller of cell cycle transition dynamics. |
| title_fullStr | Transcriptional regulation is a major controller of cell cycle transition dynamics. |
| title_full_unstemmed | Transcriptional regulation is a major controller of cell cycle transition dynamics. |
| title_short | Transcriptional regulation is a major controller of cell cycle transition dynamics. |
| title_sort | transcriptional regulation is a major controller of cell cycle transition dynamics |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22238641/pdf/?tool=EBI |
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