Factors associated with research participation in a large primary care practice-based pediatric cohort: Results from the TARGet Kids! longitudinal cohort study
<h4>Background</h4> All longitudinal cohort studies strive for high participant retention, although attrition is common. Understanding determinants of attrition is important to inform and develop targeted strategies to improve study participation. We aimed to identify factors associated...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089319/?tool=EBI |
| _version_ | 1797847171129671680 |
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| author | Xuedi Li Charles D. G. Keown-Stoneman Cornelia M. Borkhoff Peter D. Wong Dana Arafeh Erika Tavares Sharon Thadani Jonathon L. Maguire Catherine S. Birken |
| author_facet | Xuedi Li Charles D. G. Keown-Stoneman Cornelia M. Borkhoff Peter D. Wong Dana Arafeh Erika Tavares Sharon Thadani Jonathon L. Maguire Catherine S. Birken |
| author_sort | Xuedi Li |
| collection | DOAJ |
| description | <h4>Background</h4> All longitudinal cohort studies strive for high participant retention, although attrition is common. Understanding determinants of attrition is important to inform and develop targeted strategies to improve study participation. We aimed to identify factors associated with research participation in a large children’s primary care cohort study. <h4>Methods</h4> In this longitudinal cohort study between 2008 and 2020, all children who participated in the Applied Research Group for Kids (TARGet Kids!) were included. TARGet Kids! is a large primary care practice-based pediatric research network in Canada with ongoing data collection at well-child visits. Several sociodemographic, health, and study design factors were examined for their associations with research participation. The primary outcome was attendance of eligible research follow-up visits. The secondary outcome was time to withdrawal from the TARGet Kids! study. Generalized linear mixed effects models and Cox proportional hazard models were fitted. We have engaged parent partners in all stages of this study. <h4>Results</h4> A total 10,412 children with 62,655 total eligible research follow-up visits were included. Mean age at enrolment was 22 months, 52% were male, and 52% had mothers of European ethnicity. 68.4% of the participants attended at least 1 research follow-up visit. Since 2008, 6.4% of the participants have submitted a withdrawal request. Key factors associated with research participation included child age, ethnicity, maternal age, maternal education level, family income, parental employment, child diagnosis of chronic health conditions, certain study sites, and missingness in questionnaire data. <h4>Conclusions</h4> Socioeconomic status, demographic factors, chronic conditions, and missingness in questionnaire data were associated with research participation in this large primary care practice-based cohort study of children. Results from this analysis and input from our parent partners suggested that retention strategies could include continued parent engagement, creating brand identity and communication tools, using multiple languages and avoiding redundancy in the questionnaires. |
| first_indexed | 2024-04-09T18:06:57Z |
| format | Article |
| id | doaj.art-8fbc28d740634779924dda995ad46f85 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-09T18:06:57Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-8fbc28d740634779924dda995ad46f852023-04-14T05:31:41ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01184Factors associated with research participation in a large primary care practice-based pediatric cohort: Results from the TARGet Kids! longitudinal cohort studyXuedi LiCharles D. G. Keown-StonemanCornelia M. BorkhoffPeter D. WongDana ArafehErika TavaresSharon ThadaniJonathon L. MaguireCatherine S. Birken<h4>Background</h4> All longitudinal cohort studies strive for high participant retention, although attrition is common. Understanding determinants of attrition is important to inform and develop targeted strategies to improve study participation. We aimed to identify factors associated with research participation in a large children’s primary care cohort study. <h4>Methods</h4> In this longitudinal cohort study between 2008 and 2020, all children who participated in the Applied Research Group for Kids (TARGet Kids!) were included. TARGet Kids! is a large primary care practice-based pediatric research network in Canada with ongoing data collection at well-child visits. Several sociodemographic, health, and study design factors were examined for their associations with research participation. The primary outcome was attendance of eligible research follow-up visits. The secondary outcome was time to withdrawal from the TARGet Kids! study. Generalized linear mixed effects models and Cox proportional hazard models were fitted. We have engaged parent partners in all stages of this study. <h4>Results</h4> A total 10,412 children with 62,655 total eligible research follow-up visits were included. Mean age at enrolment was 22 months, 52% were male, and 52% had mothers of European ethnicity. 68.4% of the participants attended at least 1 research follow-up visit. Since 2008, 6.4% of the participants have submitted a withdrawal request. Key factors associated with research participation included child age, ethnicity, maternal age, maternal education level, family income, parental employment, child diagnosis of chronic health conditions, certain study sites, and missingness in questionnaire data. <h4>Conclusions</h4> Socioeconomic status, demographic factors, chronic conditions, and missingness in questionnaire data were associated with research participation in this large primary care practice-based cohort study of children. Results from this analysis and input from our parent partners suggested that retention strategies could include continued parent engagement, creating brand identity and communication tools, using multiple languages and avoiding redundancy in the questionnaires.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089319/?tool=EBI |
| spellingShingle | Xuedi Li Charles D. G. Keown-Stoneman Cornelia M. Borkhoff Peter D. Wong Dana Arafeh Erika Tavares Sharon Thadani Jonathon L. Maguire Catherine S. Birken Factors associated with research participation in a large primary care practice-based pediatric cohort: Results from the TARGet Kids! longitudinal cohort study PLoS ONE |
| title | Factors associated with research participation in a large primary care practice-based pediatric cohort: Results from the TARGet Kids! longitudinal cohort study |
| title_full | Factors associated with research participation in a large primary care practice-based pediatric cohort: Results from the TARGet Kids! longitudinal cohort study |
| title_fullStr | Factors associated with research participation in a large primary care practice-based pediatric cohort: Results from the TARGet Kids! longitudinal cohort study |
| title_full_unstemmed | Factors associated with research participation in a large primary care practice-based pediatric cohort: Results from the TARGet Kids! longitudinal cohort study |
| title_short | Factors associated with research participation in a large primary care practice-based pediatric cohort: Results from the TARGet Kids! longitudinal cohort study |
| title_sort | factors associated with research participation in a large primary care practice based pediatric cohort results from the target kids longitudinal cohort study |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089319/?tool=EBI |
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