Resveratrol Enhances Cytotoxic Effects of Cisplatin by Inducing Cell Cycle Arrest and Apoptosis in Ovarian Adenocarcinoma SKOV-3 Cells through Activating the p38 MAPK and Suppressing AKT

Resveratrol Enhances Cytotoxic Effects of Cisplatin by Inducing Cell Cycle Arrest and Apoptosis in Ovarian Adenocarcinoma SKOV-3 Cells through Activating the p38 MAPK and Suppressing AKT

In the current study, we identified a mechanism of resveratrol (RES) underlying its anti-cancer properties against human ovarian adenocarcinoma SKOV-3 cells. We investigated its anti-proliferative and apoptosis-inducing effects in combination with cisplatin, using cell viability assay, flow cytometr...

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Bibliographic Details
Main Authors: Phateep Hankittichai, Phatarawat Thaklaewphan, Nitwara Wikan, Jirapak Ruttanapattanakul, Saranyapin Potikanond, Duncan R. Smith, Wutigri Nimlamool
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Pharmaceuticals
Subjects:
resveratrol
ovarian clear cancer
ovarian adenocarcinoma
SKOV-3 cells
p38 MAPK activation
PI3K/AKT
Online Access:https://www.mdpi.com/1424-8247/16/5/755

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