Herbal Diet and the Impact of Nutrition on Lipogenic Activity, a System Biology Study
Background and objectives: Human diet is branded with higher caloric and protein content and cooking processes in comparison with the diet of the primate species. The aim of this study was to explore the differences between human diet and chimpanzee diet which consists of fruits and vegetables, to f...
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| Format: | Article |
| Language: | English |
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Iranian Society of Pharmacognosy
2023-10-01
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| Series: | Research Journal of Pharmacognosy |
| Subjects: | |
| Online Access: | http://www.rjpharmacognosy.ir/article_178458_b91940a9bd325bebd54ab8f6f9907e0d.pdf |
| _version_ | 1797663485831675904 |
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| author | Mostafa Rezaei Tavirani Reza Mohamoud Robati* Alireza Ahmadzadeh Mohammad Rostami Nejad |
| author_facet | Mostafa Rezaei Tavirani Reza Mohamoud Robati* Alireza Ahmadzadeh Mohammad Rostami Nejad |
| author_sort | Mostafa Rezaei Tavirani |
| collection | DOAJ |
| description | Background and objectives: Human diet is branded with higher caloric and protein content and cooking processes in comparison with the diet of the primate species. The aim of this study was to explore the differences between human diet and chimpanzee diet which consists of fruits and vegetables, to find benefits and harmful aspects of human nutritional behavior. Methods: Differentially expressed genes (DEGs) of mouse liver in response to consume “human cafeteria diet” and “chimpanzee diet” were acquired form Gene Expression Omnibus (GEO) database. The DEGs were assessed based on p-adj and fold change criteria. The significant DEGs were included in a protein-protein interaction (PPI) network to form an interactome unit. Central nodes of the studied network were determined based on degree value and betweenness centrality. The identified central genes were evaluated via gene ontology. Results: Numbers of 150 significant DEGs that discriminated the two nutrition diet regimes were introduced. Fatty acid synthase (FASN), stearoyl-CoA desaturase (SCD), and farnesyl-diphosphate farnesyltransferase 1 (FDFT1) were pointed out as the central DEGs. “Activation of gene expression by SREBF (SREBP)” and “NR1H2 & NR1H3 regulate gene expression linked to lipogenesis” were highlighted as two classes of the biological terms that were related to the central DEGs. Conclusion: The findings indicated that human cafeteria diet is a lipogenic regime compared to the chimpanzee diet which is enriched with vegetables. The studied human nutrition behavior was accompanied with increased level of fatty acid synthesis enzymes beside cholesterol accumulation in body. |
| first_indexed | 2024-03-11T19:15:19Z |
| format | Article |
| id | doaj.art-8fbee66642ce4c269848db1272ab5e35 |
| institution | Directory Open Access Journal |
| issn | 2345-4458 2345-5977 |
| language | English |
| last_indexed | 2024-03-11T19:15:19Z |
| publishDate | 2023-10-01 |
| publisher | Iranian Society of Pharmacognosy |
| record_format | Article |
| series | Research Journal of Pharmacognosy |
| spelling | doaj.art-8fbee66642ce4c269848db1272ab5e352023-10-09T09:02:30ZengIranian Society of PharmacognosyResearch Journal of Pharmacognosy2345-44582345-59772023-10-01104435010.22127/rjp.2023.405866.2155178458Herbal Diet and the Impact of Nutrition on Lipogenic Activity, a System Biology StudyMostafa Rezaei Tavirani0Reza Mohamoud Robati*1Alireza Ahmadzadeh2Mohammad Rostami Nejad3Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Celiac Disease and Gluten Related Disorders Research Center, Research Institute for Gastroenterology and Liver Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Background and objectives: Human diet is branded with higher caloric and protein content and cooking processes in comparison with the diet of the primate species. The aim of this study was to explore the differences between human diet and chimpanzee diet which consists of fruits and vegetables, to find benefits and harmful aspects of human nutritional behavior. Methods: Differentially expressed genes (DEGs) of mouse liver in response to consume “human cafeteria diet” and “chimpanzee diet” were acquired form Gene Expression Omnibus (GEO) database. The DEGs were assessed based on p-adj and fold change criteria. The significant DEGs were included in a protein-protein interaction (PPI) network to form an interactome unit. Central nodes of the studied network were determined based on degree value and betweenness centrality. The identified central genes were evaluated via gene ontology. Results: Numbers of 150 significant DEGs that discriminated the two nutrition diet regimes were introduced. Fatty acid synthase (FASN), stearoyl-CoA desaturase (SCD), and farnesyl-diphosphate farnesyltransferase 1 (FDFT1) were pointed out as the central DEGs. “Activation of gene expression by SREBF (SREBP)” and “NR1H2 & NR1H3 regulate gene expression linked to lipogenesis” were highlighted as two classes of the biological terms that were related to the central DEGs. Conclusion: The findings indicated that human cafeteria diet is a lipogenic regime compared to the chimpanzee diet which is enriched with vegetables. The studied human nutrition behavior was accompanied with increased level of fatty acid synthesis enzymes beside cholesterol accumulation in body.http://www.rjpharmacognosy.ir/article_178458_b91940a9bd325bebd54ab8f6f9907e0d.pdffatty acidhumanmousenetworknutrition |
| spellingShingle | Mostafa Rezaei Tavirani Reza Mohamoud Robati* Alireza Ahmadzadeh Mohammad Rostami Nejad Herbal Diet and the Impact of Nutrition on Lipogenic Activity, a System Biology Study Research Journal of Pharmacognosy fatty acid human mouse network nutrition |
| title | Herbal Diet and the Impact of Nutrition on Lipogenic Activity, a System Biology Study |
| title_full | Herbal Diet and the Impact of Nutrition on Lipogenic Activity, a System Biology Study |
| title_fullStr | Herbal Diet and the Impact of Nutrition on Lipogenic Activity, a System Biology Study |
| title_full_unstemmed | Herbal Diet and the Impact of Nutrition on Lipogenic Activity, a System Biology Study |
| title_short | Herbal Diet and the Impact of Nutrition on Lipogenic Activity, a System Biology Study |
| title_sort | herbal diet and the impact of nutrition on lipogenic activity a system biology study |
| topic | fatty acid human mouse network nutrition |
| url | http://www.rjpharmacognosy.ir/article_178458_b91940a9bd325bebd54ab8f6f9907e0d.pdf |
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