PIM2 Induced COX-2 and MMP-9 expression in macrophages requires PI3K and Notch1 signaling.

PIM2 Induced COX-2 and MMP-9 expression in macrophages requires PI3K and Notch1 signaling.

Activation of inflammatory immune responses during granuloma formation by the host upon infection of mycobacteria is one of the crucial steps that is often associated with tissue remodeling and breakdown of the extracellular matrix. In these complex processes, cyclooxygenase-2 (COX-2) plays a major...

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Bibliographic Details
Main Authors: Kushagra Bansal, Nisha Kapoor, Yeddula Narayana, Germain Puzo, Martine Gilleron, Kithiganahalli Narayanaswamy Balaji
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2654112?pdf=render

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