Bile Acids Activated Receptors Regulate Innate Immunity
Once known exclusively for their role in nutrients absorption, primary bile acids, chenodeoxycholic and cholic acid, and secondary bile acids, deoxycholic and lithocholic acid, are signaling molecules, generated from cholesterol breakdown by the interaction of the host and intestinal microbiota, act...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2018-08-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.01853/full |
| _version_ | 1818149815614177280 |
|---|---|
| author | Stefano Fiorucci Michele Biagioli Angela Zampella Eleonora Distrutti |
| author_facet | Stefano Fiorucci Michele Biagioli Angela Zampella Eleonora Distrutti |
| author_sort | Stefano Fiorucci |
| collection | DOAJ |
| description | Once known exclusively for their role in nutrients absorption, primary bile acids, chenodeoxycholic and cholic acid, and secondary bile acids, deoxycholic and lithocholic acid, are signaling molecules, generated from cholesterol breakdown by the interaction of the host and intestinal microbiota, acting on several receptors including the G protein-coupled bile acid receptor 1 (GPBAR1 or Takeda G-protein receptor 5) and the Farnesoid-X-Receptor (FXR). Both receptors are placed at the interface of the host immune system with the intestinal microbiota and are highly represented in cells of innate immunity such as intestinal and liver macrophages, dendritic cells and natural killer T cells. Here, we review how GPBAR1 and FXR modulate the intestinal and liver innate immune system and contribute to the maintenance of a tolerogenic phenotype in entero-hepatic tissues, and how regulation of innate immunity might help to explain beneficial effects exerted by GPBAR1 and FXR ligands in immune and metabolic disorders. |
| first_indexed | 2024-12-11T13:13:02Z |
| format | Article |
| id | doaj.art-8fc13c5d22ca44df83b1a3b97e78352b |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T13:13:02Z |
| publishDate | 2018-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-8fc13c5d22ca44df83b1a3b97e78352b2022-12-22T01:06:07ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-08-01910.3389/fimmu.2018.01853366411Bile Acids Activated Receptors Regulate Innate ImmunityStefano Fiorucci0Michele Biagioli1Angela Zampella2Eleonora Distrutti3Section of Gastroenterology, Department of Surgical and Biomedical Sciences, University of Perugia, Perugia, ItalySection of Gastroenterology, Department of Surgical and Biomedical Sciences, University of Perugia, Perugia, ItalyDepartment of Pharmacy, University of Naples Federico II, Naples, ItalyAzienda Ospedaliera di Perugia, University of Perugia, Perugia, ItalyOnce known exclusively for their role in nutrients absorption, primary bile acids, chenodeoxycholic and cholic acid, and secondary bile acids, deoxycholic and lithocholic acid, are signaling molecules, generated from cholesterol breakdown by the interaction of the host and intestinal microbiota, acting on several receptors including the G protein-coupled bile acid receptor 1 (GPBAR1 or Takeda G-protein receptor 5) and the Farnesoid-X-Receptor (FXR). Both receptors are placed at the interface of the host immune system with the intestinal microbiota and are highly represented in cells of innate immunity such as intestinal and liver macrophages, dendritic cells and natural killer T cells. Here, we review how GPBAR1 and FXR modulate the intestinal and liver innate immune system and contribute to the maintenance of a tolerogenic phenotype in entero-hepatic tissues, and how regulation of innate immunity might help to explain beneficial effects exerted by GPBAR1 and FXR ligands in immune and metabolic disorders.https://www.frontiersin.org/article/10.3389/fimmu.2018.01853/fullinnate immunitybile acidsFarnesoid-X-receptorG-protein bile acid receptor 1intestinal microbiota |
| spellingShingle | Stefano Fiorucci Michele Biagioli Angela Zampella Eleonora Distrutti Bile Acids Activated Receptors Regulate Innate Immunity Frontiers in Immunology innate immunity bile acids Farnesoid-X-receptor G-protein bile acid receptor 1 intestinal microbiota |
| title | Bile Acids Activated Receptors Regulate Innate Immunity |
| title_full | Bile Acids Activated Receptors Regulate Innate Immunity |
| title_fullStr | Bile Acids Activated Receptors Regulate Innate Immunity |
| title_full_unstemmed | Bile Acids Activated Receptors Regulate Innate Immunity |
| title_short | Bile Acids Activated Receptors Regulate Innate Immunity |
| title_sort | bile acids activated receptors regulate innate immunity |
| topic | innate immunity bile acids Farnesoid-X-receptor G-protein bile acid receptor 1 intestinal microbiota |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.01853/full |
| work_keys_str_mv | AT stefanofiorucci bileacidsactivatedreceptorsregulateinnateimmunity AT michelebiagioli bileacidsactivatedreceptorsregulateinnateimmunity AT angelazampella bileacidsactivatedreceptorsregulateinnateimmunity AT eleonoradistrutti bileacidsactivatedreceptorsregulateinnateimmunity |